唐定中，教授，博士生导师，国家杰出青年科学基金获得者，福建农林大学植物免疫研究中心主任 1992年武汉大学生物系学士；1995年福建农业大学硕士；1996-1997年英国JohnInnesCentre访问学者；1998年福建农业大学博士。1998-1999中科院发育所博士后。1999-2006年Indiana大学博士后。2006年入选中科院“百人计划”，2006-2016任中科院遗传与发育生物学研究所研究员和博士生导师，2011-2016任植物细胞与染色体工程国家重点实验室副主任。2015年获国家杰出青年科学基金；2017年入选“国家百千万人才工程”家并被授予“有突出贡献中青年专家”荣誉称号。2017年1月任福建农林大学教授，植物免疫研究中心主任。长期从事植物免疫分子机制及其信号转导途径的研究。利用白粉菌与拟南芥相互作用体系，系统研究植物与病原菌互作的分子机制。主要学术贡献包括发现了多个调控植物免疫反应的重要基因，并解析了其调控植物免疫的分子机理，系统解析了白粉病抗性反应的调控机制，揭示了抗病基因激活的分子机理，以及揭示了MAPK级联信号通路精细调控植物抗病性的分子机理等。近几年来，作为通讯作者在PNAS,PlantCell，PLoSGenetics,PlantJournal，PlantPhysiology及NewPhytologist等国际主流学术刊物上发表一系列论文，多次应邀参加国际会议，并作大会报告。

植物与病原菌的相互作用，主要研究植物免疫的分子机制及其信号转导途径

1.植物免疫的分子机制

利用模式植物拟南芥，采用遗传学，分子生物学以及生物化学的方法，分离和鉴定植物免疫信号通路中的重要组分，研究植物免疫的分子机理。近年来，利用拟南芥与白粉菌互作体系，我们在植物免疫分子机制研究中取得了许多新的进展。例如，我们发现油菜素甾醇受体BRI1的底物BSK1是免疫受体复合体成员，与病原相关分子模式（PAMPs）受体FLS2互作，调控植物的抗病反应，揭示油菜素甾醇信号与植物基础抗性（PTI）之间的交互应答（Shietal.,2013）；发现钙调素结合的转录因子SR1作为水杨酸信号通路和乙烯信号通路在转录水平调控的一个关键交叉点，精细调控植物的抗性和衰老反应(Nieetal.,2012)；发现26S蛋白亚基RPN1a直接参与植物的先天免疫反应(Yaoetal.,2012)；发现在植物中THO/TREX蛋白复合体对mRNA的核质运输的调控作用，发现THO/TREX蛋白复合体的组分HPR1是基础抗性和乙烯信号的重要调节因子(Panetal.,2012)；此外，我们还发现细胞自噬过程影响白粉病的抗性，并证实自噬过程在植物细胞凋亡的调节中起重要作用(Wangetal.，2011)。我们发现EDR1与MKK4/5互作，揭示MAPK信号通路精细调控植物抗病性的分子机理（Zhaoetal.,2014），而EDR4通过调控EDR1的亚细胞定位来影响植物先天免疫反应（Wuetal.,2015）;我们还发现非典型胞内免疫受体可能监控胞吐复合体成员(Zhaoetal.,2015)，而钙依赖蛋白激酶CPK5参与非典型胞内免疫受体激活的抗性反应（Liuetal.,2017）。同时采用遗传学的手段我们还现免疫模式受体复合体的新成员LLG1，并通过分子生物学及细胞生物学方法解析了LLG1、BSK1调控植物免疫的分子机理（Shenetal.,2017；Yanetal.,2018）等。我们将利用已有的研究基础，进一步解析植物抗病反应的信号转导途径和网络调控机制。 2.重要作物病害的抗性机制

稻瘟病是水稻生产上最重要的病害，尽管近10多年来对稻瘟病的研究已取得了不少成果，克隆了多个稻瘟病抗性基因，然而，对这些抗性基因的作用机制还很不清楚。我们将利用遗传学、细胞生物学、分子生物学及生化的方法，研究水稻与稻瘟菌的分子互作，鉴定和克隆调控稻瘟病抗性的基因以及稻瘟菌中的效应蛋白，阐明水稻调控抗病反应的分子机制。小麦白粉病和锈病是小麦生产最主要的病害，由于小麦基因组复杂，目前对小麦病害的研究还很不够。我们将以二倍体小麦祖先种乌拉尔图为基础，利用小麦功能基因组学研究中的最新成果，鉴定具有广谱和持久抗性的小麦白粉病及锈病的抗性基因，为小麦抗病育种中提供重要基因资源(Zhangetal.,2017;Zouetal.,2018)。

现任FrontiersinPlantScience及FrontiersinMicrobiology刊物编委（AssociateEditor），福建省遗传学会理事长，闽台作物有害生物生态防控国家重点实验室副主任，中国植物生理与植物分子生物学学会“植物－微生物分子互作”专业委员会委员。

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