个人简介
获武汉大学理学学士和遗传学博士学位,2009-2015年在美国印第安纳大学医学院和杜兰大学医学院从事研究工作,先后任博士后和助理研究员。2016年任复旦大学附属肿瘤医院/肿瘤研究所和生物医学研究院课题组长,现担任复旦大学肿瘤研究所所长助理。获美中抗癌协会-亚洲癌症研究基金会学术奖,获国家自然科学基金和上海高水平地方高校创新团队资助。任中国抗癌协会妇瘤标志物协作组常务委员、上海医学会肿瘤靶分子青委会委员等。任J Mol Cell Biol、Cancer Medicine等杂志(青年)编委。主要开展肿瘤演进的分子机制和转化研究,申请和授权多项发明专利,研究成果发表于PNAS、Cell Death Differ、Redox Biology、Mol Cancer、Clin Transl Med、Oncogene等。
研究领域
p53及其突变体的功能与机制 p53相关非编码RNA的功能与机制 核仁应激的分子机理和转化研究 细胞应激信号与肿瘤代谢
近期论文
Gan Y, Deng J, Hao Q, Huang Y, Han T, Xu JG, Zhao M, Yao L, Xu Y, Xiong J, Lu H, Wang C, Chen J*, Zhou X*. UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis. Redox Biol. 2023 Jun;62:102705. Dong H, Liao Q, Xie B, Qiu YA, Peng Z, Deng J, Xiong J, Lu H, Hao Q*, Zhou X*. Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth. Sci China Life Sci. 2023 Aug 11. Xiong C, Ling H, Hao Q*, Zhou X*. Cuproptosis: p53-regulated metabolic cell death? Cell Death Differ. 2023 Apr;30(4):876-884. Chen Y, Hao Q*, Wang S, Cao M, Huang Y, Weng X, Wang J, Zhang Z, He X, Lu H, Zhou X*. Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2026813118. Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X*, Wu X*. FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2. Mol Cancer. 2021 Mar 3;20(1):45. Hao Q, Li J, Zhang Q, Xu F, Xie B, Lu H, Wu X*, Zhou X*. Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma. Clin Transl Med. 2021 Aug;11(8):e500. Hao Q, Chen J, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H*, Zhou X*. p53 induces ARTS to promote mitochondrial apoptosis. Cell Death Dis. 2021 Feb 24;12(2):204. Huang C, Hao Q, Shi G, Zhou X*, Zhang Y*. BCL7C suppresses ovarian cancer growth by inactivating mutant p53. J Mol Cell Biol. 2021 May 7;13(2):141-150. Wang S, Hao Q, Li J, Chen Y, Lu H, Wu X*, Zhou X*. Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development. Genes Dis. 2020 Nov 21;9(3):705-716. Chen Y, Hao Q, Wang J, Li J, Huang C, Zhang Y, Wu X, Lu H*, Zhou X*. Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53. Cell Death Dis. 2019 Sep 30;10(10):737.