2021.03-至今东南大学化学化工学院副研究员 2018.10-2020.10洛桑联邦理工学院（EPFL）合作导师：Prof. Jieping Zhu 2012.9-2018.6 华中师范大学有机化学导师：吴安心教授 2017.9-2018.3中科院上海有机所金属有机化学导师：游书力研究员（联合培养） 2008.9-2012.6 华中师范大学化学-生物学基地班应用化学，生命科学（双学位）

有机合成方法学，天然产物全合成 发展“机制新颖的化学转化”用于“优化天然产物全合成”一直是有机合成方法学研究的重要归宿之一。不仅有助于化学机理的深入理解，创造新的反应类型，还能开拓逆合成思路，助力复杂、多样化、优势骨架分子群的快速构建，为研究药物活性、构效关系提供物质基础。 课题组致力于天然产物导向型反应方法学的创建---旨在利用逻辑设计的逆合成分析，以多米诺串联反应为手段，为天然产物提供简洁的构筑策略，从而减少全合成步骤，乃至实现“一锅法”全合成。现以完成33例天然产物的合成工作，涵盖吲哚生物碱，鬼臼类、呋喃类木脂素，多羟基苯偶酰等多类天然产物家族，全合成步骤均不超过3步，具有显著的步骤经济性优势。其中包括“一锅法”全合成17例，首次全合成12例。

Jia-chen Xiang,Cédric Fung, Qian WangandJieping Zhu*, Taming the radical cation intermediate enabledone-step access to structurally diverse lignansNat Commun2022,13, 3481(Impact Factor: 14.92, Q1-top期刊) (Nature Index) Jia-chen Xiang,QianWangandJiepingZhu*, Radical Cation Cascade to Aryltetralin Cyclic Ether Lignans Enabled by Visible Light Photoredox CatalysisAngew. Chem. Int. Ed.2020,59, 21195-21202.(Impact Factor:15.34,Q1-top期刊) (Nature Index) Jia-chen Xiang,Yan Cheng, Zi-xuan Wang, Jin-tian Ma, Miao Wang, Bo-cheng Tang, Yan-dong Wu,and An-xin Wu*, Oxidative Trimerization of Amino Acids: Selective Synthesis of 2,3,5-Trisubstituted PyridinesOrg. Lett. 2017, 19, 2997-3000 (Impact Factor: 6.58,Q1-top期刊) (Nature Index) Jia-chen Xiang,Yan Cheng, Miao Wang, Yan-dong Wu,* and An-xin Wu*, Direct Construction of 4-Hydroxybenzils via para-Selective C-CBond Coupling of Phenols and Aryl Methyl KetonesOrg. Lett. 2016, 18, 4360-4363(Impact Factor: 6.73,Q1-top期刊) (Nature Index) Jia-chen Xiang,Miao Wang, Yan Cheng, and An-xin Wu*, Molecular Iodine-Mediated Chemoselective Synthesis ofMultisubstituted Pyridines through Catabolism and ReconstructionBehavior of Natural Amino AcidsOrg. Lett.,2016, 18, 24-27(Impact Factor: 6.73,Q1-top期刊)(Highlighted by: Cheminform, 2016, 47(20))(Nature Index) Jia-chen Xiang†，Zhi-jie Wu,†Qing Gu*, Shu-li You*,Palladium-Catalyzed C–H Diarylation of Ferrocenecarboxylic Acids with Aryl IodidesJ. Org. Chem.,2019,84, 13144-13149(Impact Factor: 4.81,Q1-top期刊) Jia-chen Xiang,Zi-xuan Wang, Yan Cheng, Shi-qing Xia, Miao Wang, Bo-cheng Tang, Yan-dong Wua and An-xin Wu*, Divergent Synthesis of Functionalized Quinolines from Aniline and Two Distinct Amino AcidsJ. Org. Chem.,2017, 82, 9210−9216(Impact Factor: 4.85,Q1-top期刊)(Highlighted by: Organic Chemistry Portal, J42-Y2017) Jia-chen Xiang,Zi-xuan Wang, Yan Cheng, Jin-tian Ma, Miao Wang, Bo-cheng Tang, Yan-dong Wuand An-xin Wu*, A C−H Oxidation/Two-Fold CyclizationApproach toImidazopyridoindole Scaffold under Mild Oxidizing ConditionsJ. Org. Chem.2017, 82, 13671-13677(Impact Factor: 4.85,Q1-top期刊) Zi-Xuan Wang†, Jia-chen Xiang†,Yan Cheng, Jin-Tian Ma, Yan-Dong Wu, and An-Xin Wu*, Direct Biomimetic Synthesis of β-Carboline Alkaloids from Two Amino AcidsJ. Org. Chem., 2018,83, 12247–12254(Impact Factor: 4.81,Q1-top期刊, 共同第一作者) Jia-chen Xiang,Jun-gang Wang, Miao Wang, Xiang-gao Meng and An-xin Wu*, One-pot total synthesis of streptindole,arsindoline B and their congeners through tandemdecarboxylative deaminative dual-couplingreaction of amino acids with indolesOrg. Biomol. Chem., 2015, 13, 4240-4247(Impact Factor: 3.56,Q1期刊) (Highlighted by: Cheminform, 2016, 46(32)) Jia-chen Xiang,Jun-gang Wang, Miao Wang, Xiang-gao Meng, An-xin Wu*, One-pot total synthesis: the first total synthesis of chiral alkaloidpimprinol A and the facile construction of its natural congenersfrom amino acidsTetrahedron,2014, 70,7470-7475(Impact Factor: 2.83) (Highlighted by: Cheminform,2015,46(10)) Jia-chen Xiang,Jun-gang Wang, Li-ming Zhang, Syntheses and Crystal Structureof a New Molecular Clip Based onDiethoxycarbonyl Glycoluril:C54H38N8O6·H2OChinese J. Struct. Chem., 2013, 33, 544-548 Jia-chen Xiang,Miao Wang, Yu Sun, and An-xin Wu*, Chapter 8:One-Pot TotalSynthesis of BioactiveNatural Products(国外专业书籍章节)CRC Press, 2017,ISBN 9781498734127doi:10.1201/9781315369754-9 Jia-chen Xiang,Qing-He Gao, andAn-xinWu* Chapter 7: The Applications of DMSO. (国外专业书籍章节)Wiley-VCH,2017,ISBN: 978-3-527-80563-1doi:10.1002/9783527805624.ch7 Jia-chen Xiang,Ting-ting Hu and Jun-gang Wang, Ethyl-2-(4-methylbenzoyl)-2,3-dihydro-1H-indene-2-carboxylateActa Cryst.,2013,E69, o50417.Miao Wang, Jia-chen Xiang,Yan Cheng, Yan-dong Wu,* and An-xin Wu*, Synthesis of 2,4,5-Trisubstituted Furans via a Triple C(sp3)-H Functionalization Reaction Using Rongalite as the C1 Unit.Org. Lett.,2016,18, 524–527 Jun-gang Wang, Meng Wang, Jia-chen Xiang,Yan-ping Zhu, Wei-jian Xue, and An-xinWu*, Direct Synthesis of Substituted Naphthalenes from 1,3-Dicarbonyl Compounds and 1,2-Bis(halomethyl)benzenes Including a Novel Rearrangement Aromatization of Benzo[c]oxepine.Org. Lett.,2012,14, 6060–6063 Jun-gang Wang, Jia-chen Xiang,Miao Wang, Jie Guan, An-xin Wu*,Synthesis of substituted naphthalenes from a-substituted ketonesand 1,2-bis(halomethyl)benzenes including a rearrangementaromatization of benzo[c]oxepine. Tetrahedron,2014, 70,1412-1417 Miao Wang, Jun-gang Wang,Jia-chen Xiang, and An-xin Wu*, A Regioselective Formal Coupling Reaction Between C(sp2) andC(sp3): o-Quinodimethane (o-QDM)-Mediated Domino Process forthe Construction of 3-(2-methylbenzyl)indole Derivatives. Asian J. Org. Chem., 2015, 4, 741-744 Jun-gang Wang, Jia-chen Xiang, An-xin Wu*and Xiang-gao Meng*, Robust R22(8) hydrogen bonded dimer for crystalengineering of glycoluril derivatives.CrystEngComm,2013, 15, 10079–10085 Jun-gang Wang,Miao Wang,Jia-chen Xiang,Li-ping Cao,An-Xin Wu*,Lyle D. Isaacs*, Dimeric packing of molecular clips induced by interactions between π-systems.CrystEngComm,2015,17, 2486-2495 Jun-gang Wang,Yang Gao, Jia-chen Xiang,Miao Wang and An-xin Wu*, X-ray studies of conformation: observation of conformational polymorphism of a glycoluril clip.CrystEngComm,2015,17,2245-2249 Yan Cheng,Jia-chen Xiang,Zi-xuan Wang, Jin-tian Ma, Miao Wang, Bo-chengTang, Yan-Dong Wu, Yan-Ping Zhu*, and An-Xin Wu*,Dimerization of Phenylalanine: An Approach to Thiazoles andOxazoles Involved S/O-InsertionAdv. Synth. Catal. 2018,360, 550-555 Miao Wang,Bo-cheng Tang,Jin-tian Ma,Zi-xuan Wang, Jia-chen Xiang,Yan-dong Wu, Jun-Gang Wang*,An-Xin Wu*,I2/DMSO-mediated multicomponent reaction of o-hydroxyaryl methyl ketones, rongalite, and DMSO: access to C3-sulfenylated chromonesOrg. Biomol. Chem., 2019,17, 1535-1541 Miao Wang, Bo-cheng Tang, Jia-chen Xiang,Yan Cheng, Zi-xuan Wang, Jin-tianMa, Yan-dong Wu, and An-Xin Wu*,C(sp3)–H Bond Functionalization of Benzo[c]oxepines via C–O bond Cleavage: Formal [3+3] Synthesis of Multisubstituted ChromansJ. Org. Chem., 2018, 83, 3409-3416 Jun-gang Wang, Yan Cheng, Jia-chen Xiang,Anxin Wu*, Synthesis of 2,5-Disubstituted Oxazoles from Arylacetylenes and α-Amino Acids through an I2/Cu(NO3)2•3H2O-Assisted Domino SequenceSynlett 2019,30, 743-747. Zi-xuan Wang, Jia-chen Xiang,Miao Wang, Jin-Tian Ma,Yan-Dong Wu, and An-Xin Wu*, One-Pot Total Synthesis of Evodiamine and Its Analogues through a Continuous Biscyclization ReactionOrg. Lett.,2018,20,6380-6383 Miao Wang,Bo-cheng Tang,Jun-gang Wang,Jia-chen Xiang,Ao-Yu Guan,Ping-Ping Huang, Wu-Yinzheng Guo, Yan-Dong Wu,An-Xin Wu*, The triple role of rongalite in aminosulfonylation of aryldiazonium tetrafluoroborates: synthesis of N-aminosulfonamides via a radical coupling reactionChem. Commun., 2018,54,7641-7644 Miao Wang,Bo-cheng Tang,Jia-chen Xiang,Xiang-long Chen，Jin-Tian Ma,Yan-Dong Wu,An-Xin Wu*,Aryldiazonium Salts Serve as a Dual Synthon: Construction of Fully Substituted Pyrazoles via Rongalite-Mediated Three-Component Radical Annulation ReactionOrg. Lett.,2019,21, 8934-8937.