在高分子材料与生物、医学、工程交叉领域开展基础研究和应用研究，开发具有重要应用价值的生物材料、药物释放系统、抗肿瘤药物和高分子工程材料： 1.生物材料 · 从源头出发，利用化学、生物、物理方法，设计制备水凝胶、纳米纤维等新型高分子生物材料，通过微结构分析，建立结构与性能之间的关系 · 研发新方法创建生物水凝胶组织工程支架，分析细胞与材料相互作用，探索组织和器官培养技术，研发组织修复材料 · 研发表面可转换技术，创建新型高分子生物材料 · 开发新型高分子生物材料在眼科光学、心血管、整形外科等医疗领域的应用 2.药物释放系统 ·设计合成抗肿瘤药物、多肽药物控释系统，研究药物分子组装行为，进行药代、药效等系统研究，开发抗肿瘤一类新药 ·研究药物靶向技术、长循环技术和抗多药耐药性技术，设计、开发全新分子药物控释系统 3.高分子工程材料 · 将实验室生物材料理论研究成果和创新技术拓展至海洋、大气、水环境工程应用领域，开发新型功能高分子材料和技术

Shuo Fang, Yuge Niu,Wei Zhang, Yemin Zhang, Liangli Yu,Yingyi Zhang, and Xinsong Li*, Liposome-likenanocapsules of dual drug-tailed betaine for cancer therapy, InternationalJournal of Pharmaceutics, 2015, 493(1-2), 460–465

Xu, Chen; Hu, Xin; Wang, Jie; Zhang, Yemin; Liu, Xiaojiu; Xie,Binbin; Yao, Chen; Li, Yi; Li, Xinsong*, Library of Antifouling SurfacesDerived From Natural Amino Acids by Click Reaction, ACS Applied Materials &Interfaces, 2015,7(31):17337-45

Xiao-jiu Liu, Ye-min Zhang, Xin-song Li*, Tough biopolymer IPNhydrogel fibers by bienzymatic crosslinking approach, Chinese Journal ofPolymer Science, 2015,33(12): 1741-1749

Zhiping Fan, Yemin Zhang and Xinsong Li*,In situ injectablepoly(c-glutamic acid) based biohydrogel formed by enzymatic crosslinking , J.Appl. Polym. Sci. 2015, 2015,132（30）

ShuoFang, Yuge Niu, Wenjun Zhu, Yemin Zhang, Liangli Yu and Xinsong Li*, Liposomesassembled from a dual drug-tailed phospholipid for cancer therapy, Chemistry-an Asian journal, 2015, 10(5),1232–1238.

Yemin Zhang, Zhiping Fan, Chen Xu, Shuo Fang,Xiaojiu Liu, Xinsong Li*,Biopolymer based hydrogels withinterpenetrating network structure by bienzymaticcrosslinking approach, Europe Polymer Journal, 2015. doi:10.1016/j.eurpolymj.2014.12.038.

Zhiping Fan, Yemin Zhang, Jinkai Ji andXinsong Li*,Hybrid polypeptide hydrogels produced via native chemical ligation, RSV Adv., 2015,5, 16470

Wenjun Zhu, Shuo Fang, Yemin Zhang, XinsongLi*, Functional vesicles formed by anticancerdrug assembly,Bioorganic & Medicinal Chemistry Letters25 (2015) 188–191

ZhipingFan, Yemin Zhang, Xinsong Li*, BienzymaticallyCrosslinked Gelatin/Hyaluronic acid Interpenetrating Network Hydrogels：Preparationand Characterization, RSC Adv., 2015, 5, 1929–1936 |

XinHu, Lingling Lu, Chen Xu, Xinsong Li*, Mechanically tough biomacromolecular IPNhydrogel fibers by enzymatic and ionic crosslinking, International Journal ofBiological Macromolecules, 2015,72: 403–409.

Wu, Yang;Ji, Jingkai; Yang, Ran; Zhang, Xiaoqiang; Li, Yuanhui; Pu, Yuepu; Li,Xinsong, Galactosylated 2-hydroxypropyl methacrylamide-s-3-guanidinopropylmethacrylamide copolymer as small hairpin RNA carrier for inhibiting humantelomerase reverse transcriptase expression, Journal of Gene Medicine, 2014,16(5-6): 109-121.

Yang Wu, Jinkai Ji, Xinsong Li*, et al.,Galactosylated Poly(ethylene glycol) Methacrylate-st-3-GuanidinopropylMethacrylamide Copolymers as siRNA Carriers for Inhibiting Survivin Expression in vitro and in vivo, Journal ofDrug Targeting, 2014,22(4): 352-364.

Wang, XT ; Dai, Y ; Zhao, S ; Tang,JX ; Li, HJ ; Xing, YT ; Qu, GL; Li, XS ; Dai, JR ; Zhu,YC ,PAMAM-Lys,a Novel Vaccine Delivery Vector, Enhances the Protective Effects of the SjC23DNA Vaccine against Schistosoma japonicum Infection, PLoS, 2014;9(1):e86578,DOI: 10.1371/journal.pone.0086578.

Cai Wen, Lingling Lu andXinsong Li*, Enzymatic and Ionic Crosslinked Gelatin/K-Carrageenan IPNHydrogels as Potential Biomaterials, JAPS, 2014,132(21): DOI: 10.1002/app.40975.

Hago, Eltjani Eltahir; Lixinsong, Physical Characteristics Evaluation of IPN Poly(vinyl alcohol)/GelatinHydrogels as a Potential Tissue Engineering Scaffolds, Science of AdvancedMaterials, 2014, 6(8):1836-1844.

Eltjani Eltahir Hago, LiXinsong, and Ji Jin Kai, A New Route Toward IPN Photocrosslinked AlginateHydrogels with Biodegradation Rates, Excellent Biocompatibility and MechanicalProperties, J. Biomater. Tissue Eng. 2014, 4:89-98.

Cai Wen, Lingling Lu, XinsongLi*, An IPN Biohydrogel of Gelatin and Gellan Gum by using Combination ofEnzymatic and Ionic Crosslinking Approaches, Polymer International,2014,63:1643-9.

Yan Mei, Chen Yao, Xinsong Li*,A simple approach to constructing antibacterialand anti-biofouling nanofibrous membranes, Biofouling, 2014,30(3): 313-322

Zongzhe Zhu, Xinsong Li,Silicone hydrogels based on a novel amphiphilicpoly(2-methyl-2-oxazoline)-b-poly(dimethyl siloxane) copolymer, Journal ofApplied Polymer Science, online, 2014, 131(3): ?? DOI: 10.1002/app.39867

Cai Wen, Lingling Lu, XinsongLi*, Mechanically Robust Gelatin-Alginate IPN Hydrogels by a Combination ofEnzymatic and Ionic Crosslinking Approaches, Macromolecular Materials andEngineering, 2014, 299(4): 504-13.

Yang Wu, Jinkai Ji, XinsongLi*, et al., Guanidinylated 3-gluconamidopropyl methacrylamide-s-3-aminopropylmethacrylamide copolymer as siRNA carriers for inhibiting human telomerasereverse transcriptase expression, Drug delivery, 2013;20(7):296-305.

Yan Mei, Zhiming Wang, XinsongLi*, Improving filtration performance of electrospun nanofiber mats by abimodal method, Journal of Applied Polymer Science, 2013, 128(2):1089–1094.

Xinsong Li*, Zhu Qin, et al.,Improvement of transfection efficiency by galactosylated N -3-guanidinopropylmethacrylamide-co-poly(ethyleneglycol)methacrylatecopolymer, European Polymer Journal, 2013, 49(10): 2884–2894

Hago, EE, Xinsong Li*,Interpenetrating Polymer Network Hydrogels Based on Gelatin and PVA byBiocompatible Approaches: Synthesis and Characterization, ADVANCES IN MATERIALSSCIENCE AND ENGINEERING,2013,文献号:328763DOI: 10.1155/2013/328763,WOS:000321348600001.

Yan Mei, Chen Yao, Kai Fan,Xinsong Li, Surface modification of polyacrylonitrile nanofibrous membraneswith superior antibacterial and easy-cleaning properties through hydrophilicflexible spacers, Journal of Membrane Science, Journal ofMembrane Science, 2012, 417–418,20–27.