李炜玲 职务: 副教授 专业: 生物技术 Education/Working Experience

1999-2004 Bachelor Clinical Medicine Dalian Medical University, China 2004-2007 Master Biotechnology and Molecular Biology，Dalian Medical University, China 2007-2011 Ph.D Oncology University of Edinburgh, United Kingdom 2011-present Associate professor Biotechnology Dalian Medical University,China Research Projects/Grants

2014-2016

Identification and functional characterization of a novel transcript variant of ERCC1

National Natural Science Foundation of China

The major goal of this study is to identify a novel transcript variant of ERCC1 and investigate its roles in chemotherapy resistance in ovarian cancer 2014-2018

The basic study of alternative end joining repair on DNA double strands break

National Natural Science Foundation of China

The goal of this study is to investigate the role of ligase I in A-EJ and the function of A-EJ in maintaining genomic stability of cells. Admission Plan/Requirements

Admission Plan: 2 masters

2010-present Society for Melanoma Research Member

1.Liu J, Bai J, Jiang G, Li X, Wang J, Wu D, Owusu L, Zhang E, Li W*.Anti-Tumor Effect of Pinus massoniana Bark Proanthocyanidins on Ovarian Cancer through Induction of Cell Apoptosis and Inhibition of Cell Migration. PLoS One. 2015;10(11):e0142157.

2.Owusu L, Wang B, Du Y, Li W*, Xin Y*. The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression. Journal of Cancer. 2015;1;6(2):128-38.

3.Chen Y, Liu ZJ, Liu J, Liu LK, Zhang ES, Li WL*. Inhibition of metastasis and invasion of ovarian cancer cells by crude polysaccharides from rosa roxburghii tratt in vitro. Asian Pac J Cancer Prev. 2014;15(23):10351-4.

4.Wan Y, Xin Y, Zhang C, Wu D, Ding D, Tang L, Owusu L, Bai J, Li W*. Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3-dependent pathway. Oncol Lett. 2014;7(5):1738-1742.

5.Li X, Zhang C, Li W, Wu D, Liu J, Tang L, Xin Y*. In vivo effects on the intestinal microflora of Physalis alkekengi var. francheti extracts. Fitoterapia. 2013;87:43-8.

6.Weiling Li and D W Melton*. Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. Oncogene, 2012, 10;31(19):2412-22.

7.Weiling Li, Liang Song and D W Melton*. Increased levels of DUSP6 phosphatase stimulate tumourigenesis in a molecularly distinct melanoma subtype. Pigment Cell Melanoma Res. 2012, 25(2):188-99.

8.Liang Song, Ann-Marie Ritchie, Ewan M. McNeil, Weiling Li, David W. Melton*. 2011, Identification of DNA repair gene Ercc1 as a novel target in melanoma. Pigment Cell Melanoma Res. 24: 5, 966–971.