教育经历 2000.4 2003.3 九州大学理学部 分子生物学 博士 1997.4 2000.3 九州大学理学部 分子生物学 硕士 1984.7 1988.9 辽宁大学生物系 生物学 学士 1981.9 1984.7 辽师附属高中 无 工作经历 2005.12 至今 大连理工大学 2003.10 2005.11 北京大学医学部 博士后 2003.4 2003.9 九州大学理学部 博士研究员 1988.8 1997.3 大连市环保局 工程师、主任科员

蛋白质化学修饰与细胞的信号转导 基因转录调控与肿瘤

Sun Dongsheng,Liu Yang,Wang Huihui,Deng Fei,Zhang Ying,Zhao Shan,Ma Xiaojun,Wu Huijian,Sun Guangwei.Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.[J],International journal of biological macromolecules,2018,109:1154-1163 Chen Huan,Wang Miao,Wu Huijian,Xu Zhaowei,Li Xiahui,Yang Yangyang,Li Bowen,Li Yanan,Xia Kangkai,Wang Jian,Li Shujing.α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression[J],Oncogenesis,2018,7(3):28 Jia Zhaojun,Wu Huijian,Wang Miao,Li Shujing,Li Xiahui,Bai Xiao-Yan,Xu Zhaowei,Yang Yangyang,Li Bowen,Li Yanan.U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation.[J],Cell death & disease,2018,9(2):63 Xu, Zhaowei,Wu, Huijian,Yang, Yangyang,Li, Bowen,Li, Yanan,Xia, Kangkai,Yang, Yuxi,Li, Xiahui,Wang, Miao,Li, Shujing.Checkpoint suppressor 1 suppresses transcriptional activity of ERalpha and breast cancer cell proliferation via deacetylase SIRT1.[J],Cell death & disease,2018,9(5):559 Wang, Miao,Yang, Yuxi,Xu, Jian,Bai, Wen,Ren, Xueli,Wu, Huijian.CircRNAs as biomarkers of cancer: a meta-analysis.[J],BMC cancer,2018,18(1):303 Bai, Xiao-Yan,Chen, Huan,Wu, Huijian,Li, Shujing,Wang, Miao,Li, Xiahui,Yang, Yangyang,Xu, Zhaowei,Li, Bowen,Li, Yanan,Xia, Kangkai.Kruppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion[J],CANCER LETTERS,2018,412(412):224-235 Chen, Huan,Wang, Miao,Wu, Huijian,Xu, Zhaowei,Li, Xiahui,Yang, Yangyang,Li, Bowen,Li, Yanan,Xia, Kangkai,Wang, Jian,Li, Shujing.alpha-catenin SUMOylation increases IkappaBalpha stability and inhibits breast cancer progression.[J],Oncogenesis,2018,7(3) Wang, Miao,Chen, Huan,Wu, Huijian,Li, Shujing,Xu, Zhaowei,Li, Xiahui,Yang, Yangyang,Li, Bowen,Li, Yanan,Guo, Jing.SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling[J],ONCOTARGET,2017,8(52):89692-89706 郭静,曲鑫建,伍会健.肿瘤免疫疗法中免疫检查点的研究进展[J],生理科学进展,2017,48(4):287-293 Sun Dongsheng,Liu Yang,Wu Hao,Ren Ying,Ma Xiaojun,Wu Huijian,Sun Guangwei.Effects of gelling bath on the physical properties of alginate gel beads and the biological characteristics of entrapped HepG2 cells.[J],Biotechnology and applied biochemistry,2017,65(2):263-273 李霞辉,李淑晶,伍会健.近日节律对乳腺癌他莫昔芬耐药的影响[J],生命的化学,2017,37(3):313-318 孙静静,王淼,伍会健.TRIM在肿瘤发生发展中的作用[J],中国细胞生物学学报,2017,39(1):106-113 陈欢,王淼,伍会健.上皮-间质转化在肿瘤侵袭、转移及化疗耐药中的研究进展[J],中国细胞生物学学报,2017,39(7):978-983 伍会健.Krüppel-like factor 9 Down-Regulates Matrix Metalloproteinase 9 Transcription and[J],Cancer Letters,2017,412:224-235 苏启明,曲鑫建,伍会健.ELF5 在正常乳腺发育和乳腺肿瘤发生中的作用[J],生命科学研究,2017,21(3):262-267 Li, Shujing,Wang, Miao,Qu, Xinjian,Xu, Zhaowei,Yang, Yangyang,Su, Qiming,Wu, Huijian.SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination[J],ONCOTARGET,2016,7(31):50507-50519 Jiang, Xiao,Zhang, Mei,Bai, Xiao-Yan,Li, Shujing,Wu, Huijian.Association between 17q25.3-rs6465657 polymorphism and prostate cancer susceptibility: a meta-analysis based on 19 studies[J],ONCOTARGETS AND THERAPY,2016,9:4491-4503 Ao, Xiang,Li, Shujing,Xu, Zhaowei,Yang, Yangyang,Chen, Min,Jiang, Xiao,Wu, Huijian.Sumoylation of TCF21 downregulates the transcriptional activity of estrogen receptor-alpha[J],ONCOTARGET,2016,7(18):26220-26234 李亚楠,白晓彦,伍会健.上皮间质转化抑制剂及其在抗肿瘤治疗中的应用[J],中国生物化学与分子生物学报,2016,32(11):1185-1191 伍会健.TRIM在肿瘤发生发展中的作用[J],中国细胞生物学学报,2016,39(1):106-113 伍会健.DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase[J],Science Foundation in China,2016,24(1):43-43 伍会健.生物节律蛋白对乳腺癌发生发展的调控机制[A],2015年中国中西医结合学会时间生物医学专业委员会学术研讨暨换届会议,2015,74-74 Bi, H.,Yang, Y.,Wu, H.,Li, S.,Qu, X.,Wang, M.,Bai, X.,Xu, Z.,Ao, X.,Jia, Z.,Jiang, X..DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase[J],CELL DEATH & DISEASE,2015,6(9):e1891 Bai, Xiao-Yan,Qu, Xinjian,Jiang, Xiao,Xu, Zhaowei,Yang, Yangyang,Su, Qiming,Wang, Miao,Wu, Huijian.Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects[J],JOURNAL OF CANCER,2015,6(9):913-921 Li, Shen,Lv, Guojun,Wu, Huijian,Ma, Xiaojun,Zhang, Ying,Chen, Li,Li, Na,Xie, Hongguo,Guo, Xin,Zhao, Shan,Yu, Weiting,Lv, Yan.The relationship between the inflammatory response and cell adhesion on alginate-chitosan-alginate microcapsules after transplantation[J],JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2015,103(7):2333-2343 Ao, Xiang,Liu, Ying,Bai, Xiao-Yan,Qu, Xinjian,Xu, Zhaowei,Hu, Gaolei,Chen, Min,Wu, Huijian.Association between EHBP1 rs721048(A > G) polymorphism and prostate cancer susceptibility: a meta-analysis of 17 studies involving 150,678 subjects[J],ONCOTARGETS AND THERAPY,2015,8:1671-1680 姜潇,白晓彦,伍会健.PPARs在非酒精性脂肪性肝病发病机制中的作用[J],生理科学进展,2015,46(3):220-224 Bai, Xiao-Yan,Li, Shujing,Wang, Miao,Qu, Xinjian,Hu, Gaolei,Xu, Zhaowei,Chen, Min,He, Guo-Wei,Wu, Huijian.Association of Monocyte Chemoattractant Protein-1 (MCP-1)-2518A > G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta-Analysis[J],ANNALS OF HUMAN GENETICS,2015,79(3):173-187 Ma, Cai-Xia,Zhou, Chun-Yan,Zou, Yunzeng,Nemer, Mona,Zhang, Shan-Feng,Bai, Xiaowen,Wu, Huijian,Zang, Ming-Xi,Song, Yang-Liu,Xiao, Liyun,Xue, Li-Xiang,Li, Wen-Juan,Laforest, Brigitte,Komati, Hiba,Wang, Wei-Ping,Jia, Zhu-Qing.EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner[J],CELLULAR AND MOLECULAR LIFE SCIENCES,2015,72(10):2005-2022 Liu, Ying,Ao, Xiang,Jia, Zhaojun,Bai, Xiao-Yan,Xu, Zhaowei,Hu, Gaolei,Jiang, Xiao,Chen, Min,Wu, Huijian.FOXK2 Transcription Factor Suppresses ER alpha-positive Breast Cancer Cell Growth Through Down-Regulating the Stability of ER alpha via mechanism involving BRCA1/BARD1[J],SCIENTIFIC REPORTS,2015,5:8796 Zhao, F.,Wang, M.,Li, S.,Bai, X.,Bi, H.,Liu, Y.,Ao, X.,Jia, Z.,Wu, H..DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis[J],ONCOGENESIS,2015,4(3):e143 Cui, Xiaoneng,Zhao, Jianzhang,Lou, Zhangrong,Li, Shujing,Wu, Huijian,Han, Ke-li.Switching of the Triplet Excited State of Rhodamine/Naphthaleneimide Dyads: An Experimental and Theoretical Study[J],JOURNAL OF ORGANIC CHEMISTRY,2015,80(1):568-581 张梅,王淼,伍会健.SUMO化修饰系统及其在肿瘤发展中的作用[J],中国细胞生物学学报,2015,37(10):1458-1464 伍会健.GPS2的SUMO化修饰对乳腺癌发生发展的调控机理[A],2015 赵建章,伍会健.Maximizing the Thiol-Activated Photodynamic and Fluorescence Imaging Functionalities of Theranostic Reagents by Modularization of the Bodipy-based Dyad Triplet Photosensitizers[J],J. Mater. Chem. B,2015,3(47) 伍会健.DEC1 regulates breast cancer cell proliferation by stabilizing cyclinE protein and delays the progression of cell cycle S phase[A],2015 伍会健.核心节律蛋白CLOCK对乳腺癌发生发展的调控机理[A],2015 Zhao, Jianzhang,Huang, Ling,Cui, Xiaoneng,Li, Shujing,Wu, Huijian.Maximizing the thiol-activated photodynamic and fluorescence imaging functionalities of theranostic reagents by modularization of Bodipy-based dyad triplet photosensitizers[J],JOURNAL OF MATERIALS CHEMISTRY B,2015,3(47):9194-9211 王淼,李淑晶,伍会健.跨校区网络同步教学课程模式探索 细胞生物学课程改革[J],中国细胞生物学学报,2015,37(5):715-719 陈敏,李淑晶,伍会健.泛素化与SUMO化对DNA损伤应答的调控作用简[J],生命的化学,2015,35(6):801-806 杨杨杨,李淑晶,伍会健.F-box蛋白家族在肿瘤发生中的作用[J],中国细胞生物学学报,2015,37(8):1180-1186 许兆伟,赵锋,伍会健.ERα辅调节因子在乳腺癌中的双重调控作用[J],中国细胞生物学学报,2014,10:1437-1442 Bi, Hailian,Li, Shujing,Wang, Miao,Jia, Zhaojun,Chang, Alan K.,Pang, Pengsha,Wu, Huijian.SUMOylation of GPS2 protein regulates its transcription-suppressing function[J],MOLECULAR BIOLOGY OF THE CELL,2014,25(16):2499-2508 Xiao, Liyun,Chang, Alan K.,Zang, Ming-Xi,Bi, Hailian,Li, Shujing,Wang, Miao,Xing, Xinrong,Wu, Huijian.Induction of the CLOCK Gene by E2-ER alpha Signaling Promotes the Proliferation of Breast Cancer Cells[J],PLOS ONE,2014,9(5):e95878 伍会健.The relationship between the inflammatory response and cell adhesion[J],J Biomed Mater Res A,2014,14(1):1-11 伍会健.Switching of the Triplet Excited State of Rhodamine/Naphthaleneimide Dyads: An Experimental and Theoretical Study[J],J. Org. Chem.,2014,80(1):568-581 伍会健.Induction of the CLOCK Gene by E2-ERa Signaling Promotes the Proliferation of Breast Cancer Cells[J],PLoS One,2014,9(5):1-13 王岛,Alan K Chang,伍会健.Hedgehog信号通路及其抑制剂在癌症中的研究进展[J],生命的化学,2014,34(1):98-103 李珅,董杰,伍会健.抗体介导的慢性排斥反应中内皮细胞基因的变化及分子机制[J],中国细胞生物学学报,2014,36(1):123-127 白晓彦,王淼,伍会健.一氧化氮相关的内皮功能障碍与高血压[J],生命的化学,2014,34(6):744-748 胡高磊,刘英,伍会健.NEDD化修饰系统及其在肿瘤发展中的作用[J],中国生物化学与分子生物学报,2014,30(9):843-847 许兆伟,赵锋,伍会健.ERalpha辅调节因子在乳腺癌中的双重调控作用[J],中国细胞生物学学报,2014,36(10):1437-1442 伍会健.EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner[J],Cell. Mol. Life Sci.,2014,12(14):1-18 陈艺轩,伍会健.雄激素受体翻译后修饰的研究进展[J],生理科学进展,2013,44(6):442-446 徐飞鸿,毕海连,伍会健.昼夜节律与细胞周期[J],中国生物化学与分子生物学报,2013,11:1010-1016 Li, S.,Wu, H.,Wang, M.,Ao, X.,Chang, A. K.,Yang, C.,Zhao, F.,Bi, H.,Liu, Y.,Xiao, L..CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha[J],ONCOGENE,2013,32(41):4883-4891 陈艺轩,伍会健.RNF111的SUMO修饰及其相关功能的研究[A],第四届泛环渤海生物化学与分子生物学会2013年学术交流会,2013,43-43 贾兆君,伍会健.PPIL2对HDAC2的SUMO化修饰及调控[A],第四届泛环渤海生物化学与分子生物学会2013年学术交流会,2013,45-45 徐飞鸿,伍会健.SUMO化修饰对DEC2相关功能影响的研究[A],第四届泛环渤海生物化学与分子生物学会2013年学术交流会,2013,47-47 Li, Shujing,Ao, Xiang,Wu, Huijian.The role of circadian rhythm in breast cancer[J],CHINESE JOURNAL OF CANCER RESEARCH,2013,25(4):442-450 Pan, Hongming,Niu, Wenquan,He, Lan,Wang, Bin,Cao, Jun,Zhao, Feng,Liu, Ying,Li, Shen,Wu, Huijian.Contributory Role of Five Common Polymorphisms of RAGE and APE1 Genes in Lung Cancer among Han Chinese[J],PLOS ONE,2013,8(7):e69018 Wang, Miao,Zhao, Feng,Li, Shujing,Chang, Alan K.,Jia, Zhaojun,Chen, Yixuan,Xu, Feihong,Pan, Hongming,Wu, Huijian.AIB1 Cooperates with ER alpha to Promote Epithelial Mesenchymal Transition in Breast Cancer through SNAI1 Activation[J],PLOS ONE,2013,8(6):e65556 Yang, Chunhua,Li, Shen,Wu, Huijian,Li, Shujing,Wang, Miao,Chang, Alan K.,Liu, Ying,Zhao, Feng,Xiao, Liyun,Han, Lin,Wang, Dao.PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha[J],MOLECULAR CANCER,2013,12(1):21 韩琳,伍会健.SENPs对肿瘤发展的分子调控机理[J],生理科学进展,2013,44(1):55-58 肖利云,贾兆君,伍会健.昼夜节律钟调控代谢的研究进展[J],中国细胞生物学学报,2013,35(10):1533-1539 徐飞鸿,毕海连,伍会健.时钟节律与细胞周期[J],中国生物化学与分子生物学报,2013,29(11):1010-1016 伍会健.CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.[J],Oncogene.,2013,32(10):4883-4891 伍会健.抗体介导的慢性排斥反应中内皮细胞基因的变化及分子机制[J],中国细胞生物学学报,2013,36(1):123-127 贾兆君,伍会健.DSB修复过程中的组蛋白修饰作用[J],中国细胞生物学学报,2013,35(6):863-869 伍会健.AIB1 Cooperates with ERa to Promote Epithelial Mesenchymal Transition in Breast Cancer through SNAI1 Activation.[J],Plos one.,2013,8(6):65556-65556 Xing, Xinrong,Wu, Huijian,Bi, Hailian,Chang, Alan K.,Zang, Ming-Xi,Wang, Miao,Ao, Xiang,Li, Shen,Pan, Hongming,Guo, Qianping.SUMOylation of AhR modulates its activity and stability through inhibiting its ubiquitination[J],JOURNAL OF CELLULAR PHYSIOLOGY,2012,227(12):3812-3819 Chang, Alan K.,Wu, Huijian.The role of AIB1 in breast cancer[J],ONCOLOGY LETTERS,2012,4(4):588-594 杨春华,伍会健.PTEN以磷酸酶非依赖性形式调控AIB1转录活性[A],第三届泛环渤海(七省二市)生物化学与分子生物学会2012年学术交流会,2012,10-10 韩琳,伍会健.SUMO修饰调控GPS2的转录抑制功能[A],第三届泛环渤海(七省二市)生物化学与分子生物学会2012年学术交流会,2012,12-12 赵锋,韩琳,伍会健.雌激素受体α的翻译后修饰与乳腺癌[J],生理科学进展,2012,43(3):226-230 Li, Shujing,Chang, Alan K.,Xiao, Liyun,Zhang, Yuanyuan,Wu, Huijian,Yang, Chunhua,Hong, Yongde,Bi, Hailian,Zhao, Feng,Liu, Ying,Ao, Xiang,Pang, Pengsha,Xing, Xinrong.The transcriptional activity of co-activator AIB1 is regulated by the SUMO E3 Ligase PIAS1[J],BIOLOGY OF THE CELL,2012,104(5):287-296 张园园,肖利云,伍会健.转录辅调节因子在剪接过程中的作用[J],现代生物医学进展,2012,12(7):1374-1377 潘洪明,赵锋,伍会健.泛素化和SUMO化对DEC1的拮抗调控作用[J],中国细胞生物学学报,2012,34(5):506-510 伍会健.Steroid Receptor Co-activator-3 promotes breast cancer cell invasion and metastasis through SNAI1 expression[A],遗传学为人类造福——全球华人遗传学大会论文集,2012 伍会健.DEC1 Up-regulates the Stability of Cyclin E by inhibiting its ubiquitination[A],遗传学为人类造福——全球华人遗传学大会论文集,2012 伍会健.CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α[J],Oncogene.,2012,19(10):1-9 刘英,王岛,伍会健.JunD的结构功能特征及其在肿瘤发展中的作用[J],中国生物化学与分子生物学报,2012,28(7):603-608 赵锋,韩琳,伍会健.雌激素受体alpha的翻译后修饰与乳腺癌[J],生理科学进展,2012,43(3):226-230 Hong, Yongde,Wu, Huijian,Xing, Xinrong,Li, Shujing,Bi, Hailian,Yang, Chunhua,Zhao, Feng,Liu, Ying,Ao, Xiang,Chang, Alan K..SUMOylation of DEC1 Protein Regulates Its Transcriptional Activity and Enhances Its Stability[J],PLOS ONE,2011,6(8):e23046 杨春华,刘英,伍会健.β-Trcp与肿瘤关系的研究[J],中国细胞生物学学报,2011,07:796-801 毕海连,洪永德,伍会健.SUMO化修饰与DNA损伤修复[J],生理科学进展,2011,42(2):141-144 杨春华,刘英,伍会健.beta-Trcp与肿瘤关系的研究[J],中国细胞生物学学报,2011,33(7):796-801 毕海连,伍会健.细胞周期与时钟节律的相关性研究[A],2010,88-88 刘英,伍会健.雄激素受体AR的研究进展[A],2010,85-85 庞朋沙,伍会健.GPS2在基因转录调控中的机理研究[A],2010,86-86 洪永德,伍会健.SUMO化修饰机制的研究进展[A],2010,87-87 庞朋沙,伍会健.乳腺癌治疗靶标的研究进展[A],中国遗传学会北方遗传资源的保护与利用研讨会,2010,Vol.33:1 刘英,伍会健.AhR的信号通路及功能研究[A],中国遗传学会北方遗传资源的保护与利用研讨会,2010,Vol.33:1 庞朋沙,过倩萍,伍会健.细胞内AhR信号转导通路的机制研究[J],现代生物医学进展,2010,10(13):2567-2570 李淑晶,毕海连,伍会健.泛素连接酶APC/C和SCF复合物与肿瘤的关系[J],北京大学学报（医学版）,2010,42(2):243-封3 伍会健.核受体ERa通路的研究进展[A],东北三省及内蒙古生物化学与分子生物学会,2010 伍会健.时钟蛋白DEC1的研究进展[A],东北三省及内蒙古生物化学与分子生物学会,2010 敖翔,李淑晶,伍会健.周期节律与肿瘤关系的分子机理[J],中国生物化学与分子生物学报,2010,26(11):998-1002 洪永德,罗福文,伍会健.SUMO与乳腺癌[J],现代生物医学进展,2009,9(20):3976-3979 肖利云,伍会健.PTEN对雌激素受体转录活性的调节[A],东北三省及内蒙古地区遗传学研究进展学术研讨会,2009,Vol.32:1 洪永德,伍会健.转录辅激活因子AIB1调控前体-mRNA剪接的研究[A],东北三省及内蒙古地区遗传学研究进展学术研讨会,2009,Vol.32:1 杨春华,伍会健.节律蛋白在乳腺癌中作用机制的研究[A],东北三省及内蒙古地区遗传学研究进展学术研讨会,2009,Vol.32:1 杨春华,洪永德,伍会健.SUMO对NF-κB信号通路的调控作用[J],生理科学进展,2009,40(2):154-157 刘文栋,伍会健.PIAS蛋白家族的功能[J],现代生物医学进展,2009,9(2):397-400 伍会健.Serum Inhibitor for the Trimeresurus flavoviridis Venom Phospholipase A2: Purification, Characterization and cDNA 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