教育经历 2008.9 2013.7 大连理工大学 生物化工 博士 2006.9 2008.6 大连理工大学 生物化工 硕士 2002.9 2006.6 大连理工大学 生物工程 学士 1999.9 2002.7 安阳一中 工作经历 2013.12 至今 大连理工大学 讲师

Peng, Qiang,Zang, Berlin,Zhao, Wei,Li, Da,Ren, Jun,Ji, Fangling,Jia, Lingyun.Efficient continuous-flow aldehyde tag conversion using immobilized formylglycine generating enzyme[J],CATALYSIS SCIENCE & TECHNOLOGY,2020,10(2):484-492 Zang, Berlin,Ren, Jun,Li, Da,Huang, Chundong,Ma, Ha,Peng, Qiang,Ji, Fangling,Han, Lulu,Jia, Lingyun.Freezing-assisted synthesis of covalent C-C inked bivalent and bispecific nanobodies[J],ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(2):257-263 袁文杰,姬芳玲,孜力汗,贾凌云.新工科形势下的生产实习与管理模式探索[J],高校生物学教学研究（电子版）,2018,8(6):31-34 Zhang Yue,Ji Fangling,Wang Jingyun,Pu Zhongji,Jiang Bo,Bao Yongming.Purification and characterization of a novel organic solvent-tolerant and cold-adapted lipase from Psychrobacter sp. ZY124.[J],Extremophiles : life under extreme conditions,2018,22(2):287-300 Ji, Fangling,Feng, Yanbin,Li, Mingyang,Yang, Yongliang,Wang, Tianqi,Wang, Jingyun,Bao, Yongming,Xue, Song.Studies on structure-function relationships of acetolactate decarboxylase from Enterobacter cloacae[J],RSC ADVANCES,2018,8(68):39066-39073 Wang, Qingling,Ji, Fangling,Guo, Jianli,Wang, Yuepeng,Li, Yanyan,Wang, Jingyun,An, Lijia,Bao, Yongming.LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11[J],MICROBIOLOGICAL RESEARCH,2018,214:60-73 Ji, Fangling,Bao, Yongming,Li, Mingyang,Feng, Yanbin,Wu, Sijin,Wang, Tianqi,Pu, Zhongji,Wang, Jingyun,Yang, Yongliang,Xue, Song.Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis.[J],Applied microbiology and biotechnology,2018,102(15):6479-6491 Tang, Qin,Ji, Fangling,Wang, Jingyun,Guo, Lianying,Li, Yachen,Bao, Yongming.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin[J],EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017,109:223-232 Pu, Zhongji,Ji, Fangling,Wang, Jingyun,Zhang, Yue,Sun, Wenhui,Bao, Yongming.Rational design of Meso-2,3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations[J],FEBS LETTERS,2017,591(20):3402-3413 王蒙,孙文辉,姬芳玲,蒲中机,李寅生,包永明.人巨细胞病毒抗原表位的重组表达及免疫原性分析[J],中国生物工程杂志,2017,37(7):27-33 Hao, Wenbo,Ji, Fangling,Wang, Jingyun,Wang, Yuepeng,Zhang, Yue,Bao, Yongming.Metabolic engineering of Bacillus sp for diacetyl production[J],PROCESS BIOCHEMISTRY,2017,58:69-77 Tang, Qin,Ji, Fangling,Sun, Wenhui,Wang, Jingyun,Guo, Jianli,Guo, Lianying,Li, Yachen,Bao, Yongming.Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects[J],PHYTOMEDICINE,2016,23(14):1778-1786 Song, Ting,Wang, Ziqian,Ji, Fangling,Feng, Yingang,Fan, Yudan,Chai, Gaobo,Li, Xiangqian,Li, Zhiqiang,Zhang, Zhichao.Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination[J],ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(46):14248-14254 Ji, Fangling,Li, Lu,Ma, Shuai,Wang, Jingyun,Bao, Yongming.Production of rhamnolipids with a high specificity by Pseudomonas aeruginosa M408 isolated from petroleum-contaminated soil using olive oil as sole carbon source[J],ANNALS OF MICROBIOLOGY,2016,66(3):1145-1156 Tang, Qin,Ji, Fangling,Guo, Jianli,Wang, Jingyun,Li, Yachen,Bao, Yongming.Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin[J],BIOMEDICINE & PHARMACOTHERAPY,2016,82:693-703 郝文博,姬芳玲,王静云,张悦,包永明.代谢工程改造枯草芽孢杆菌生产丁二酮[A],2016,1-1 Wang, Qingling,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Lu,An, Lijia,Li, Yachen,Bao, Yongming.Characterization of a salt-activated protease with temperature-dependent secretion in Stenotrophomonas maltophilia FF11 isolated from frozen Antarctic krill[J],JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,2016,43(6):829-840 王南,唐琴,姬芳玲,窦佳,包永明.天山雪莲细胞培养物对RANKL诱导破骨细胞的影响[J],中成药,2016,38(1):1-6 郝文博,姬芳玲,王静云,张悦,王天琪,车文实,包永明.D194 G突变对meso-2,3-丁二醇脱氢酶催化特性的影响[J],中国生物工程杂志,2016,36(1):47-54 Li, Lu,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Yachen,Bao, Yongming.Efficient mono-acylation of fructose by lipase-catalyzed esterification in ionic liquid co-solvents[J],CARBOHYDRATE RESEARCH,2015,416:51-58 eng, Qiang,Zang, Berlin,Zhao, Wei,Li, Da,Ren, Jun,Ji, Fangling,Jia, Lingyun.Efficient continuous-flow aldehyde tag conversion using immobilized formylglycine generating enzyme[J],CATALYSIS SCIENCE & TECHNOLOGY,2020,10(2):484-492 ang, Berlin,Ren, Jun,Li, Da,Huang, Chundong,Ma, Ha,Peng, Qiang,Ji, Fangling,Han, Lulu,Jia, Lingyun.Freezing-assisted synthesis of covalent C-C inked bivalent and bispecific nanobodies[J],ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(2):257-263 袁文杰,姬芳玲,孜力汗,贾凌云.新工科形势下的生产实习与管理模式探索[J],高校生物学教学研究（电子版）,2018,8(6):31-34 hang Yue,Ji Fangling,Wang Jingyun,Pu Zhongji,Jiang Bo,Bao Yongming.Purification and characterization of a novel organic solvent-tolerant and cold-adapted lipase from Psychrobacter sp. ZY124.[J],Extremophiles : life under extreme conditions,2018,22(2):287-300 i, Fangling,Feng, Yanbin,Li, Mingyang,Yang, Yongliang,Wang, Tianqi,Wang, Jingyun,Bao, Yongming,Xue, Song.Studies on structure-function relationships of acetolactate decarboxylase from Enterobacter cloacae[J],RSC ADVANCES,2018,8(68):39066-39073 ang, Qingling,Ji, Fangling,Guo, Jianli,Wang, Yuepeng,Li, Yanyan,Wang, Jingyun,An, Lijia,Bao, Yongming.LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11[J],MICROBIOLOGICAL RESEARCH,2018,214:60-73 i, Fangling,Bao, Yongming,Li, Mingyang,Feng, Yanbin,Wu, Sijin,Wang, Tianqi,Pu, Zhongji,Wang, Jingyun,Yang, Yongliang,Xue, Song.Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis.[J],Applied microbiology and biotechnology,2018,102(15):6479-6491 ang, Qin,Ji, Fangling,Wang, Jingyun,Guo, Lianying,Li, Yachen,Bao, Yongming.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin[J],EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017,109:223-232 u, Zhongji,Ji, Fangling,Wang, Jingyun,Zhang, Yue,Sun, Wenhui,Bao, Yongming.Rational design of Meso-2,3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations[J],FEBS LETTERS,2017,591(20):3402-3413 王蒙,孙文辉,姬芳玲,蒲中机,李寅生,包永明.人巨细胞病毒抗原表位的重组表达及免疫原性分析[J],中国生物工程杂志,2017,37(7):27-33 Hao, Wenbo,Ji, Fangling,Wang, Jingyun,Wang, Yuepeng,Zhang, Yue,Bao, Yongming.Metabolic engineering of Bacillus sp for diacetyl production[J],PROCESS BIOCHEMISTRY,2017,58:69-77 Tang, Qin,Ji, Fangling,Sun, Wenhui,Wang, Jingyun,Guo, Jianli,Guo, Lianying,Li, Yachen,Bao, Yongming.Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects[J],PHYTOMEDICINE,2016,23(14):1778-1786 Song, Ting,Wang, Ziqian,Ji, Fangling,Feng, Yingang,Fan, Yudan,Chai, Gaobo,Li, Xiangqian,Li, Zhiqiang,Zhang, Zhichao.Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination[J],ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(46):14248-14254 Ji, Fangling,Li, Lu,Ma, Shuai,Wang, Jingyun,Bao, Yongming.Production of rhamnolipids with a high specificity by Pseudomonas aeruginosa M408 isolated from petroleum-contaminated soil using olive oil as sole carbon source[J],ANNALS OF MICROBIOLOGY,2016,66(3):1145-1156 Tang, Qin,Ji, Fangling,Guo, Jianli,Wang, Jingyun,Li, Yachen,Bao, Yongming.Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin[J],BIOMEDICINE & PHARMACOTHERAPY,2016,82:693-703 郝文博,姬芳玲,王静云,张悦,包永明.代谢工程改造枯草芽孢杆菌生产丁二酮[A],2016,1-1 Wang, Qingling,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Lu,An, Lijia,Li, Yachen,Bao, Yongming.Characterization of a salt-activated protease with temperature-dependent secretion in Stenotrophomonas maltophilia FF11 isolated from frozen Antarctic krill[J],JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,2016,43(6):829-840 王南,唐琴,姬芳玲,窦佳,包永明.天山雪莲细胞培养物对RANKL诱导破骨细胞的影响[J],中成药,2016,38(1):1-6 郝文博,姬芳玲,王静云,张悦,王天琪,车文实,包永明.D194 G突变对meso-2,3-丁二醇脱氢酶催化特性的影响[J],中国生物工程杂志,2016,36(1):47-54 Li, Lu,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Yachen,Bao, Yongming.Efficient mono-acylation of fructose by lipase-catalyzed esterification in ionic liquid co-solvents[J],CARBOHYDRATE RESEARCH,2015,416:51-58 王南,唐琴,姬芳玲,许青,包永明.天山雪莲愈伤组织提取物对人成骨肉瘤细胞MG-63增殖及分化的影响[J],中草药,2015,46(19):2900-2907 Li, Lu,Ji, Fangling,Wang, Jingyun,Li, Yachen,Bao, Yongming.Esterification degree of fructose laurate exerted by Candida antarctica lipase B in organic solvents[J],ENZYME AND MICROBIAL TECHNOLOGY,2015,69:46-53 姬芳玲,包永明,王静云.New bifunctional-pullulan-based micelles with good biocompatibility for efficient co-delivery of cancer-suppressing p53gene and doxorubicin to cancer cells[J],RSC Advances,2015,5(5):94719-94731 Chen, Lili,Wang, Xiaohong,Ji, Fangling,Bao, Yongming,Wang, Jingyun,Wang, Xianwu,Guo, Lianying,Li, Yachen.New bifunctional-pullulan-based micelles with good biocompatibility for efficient co-delivery of cancer-suppressing p53 gene and doxorubicin to cancer cells[J],RSC ADVANCES,2015,5(115):94719-94731 Wang, Jingyun,Ji, Fangling,Xing, Jishuang,Cui, Shuang,Bao, Yongming,Hao, Wenbo.Lipase Immobilization onto the Surface of PGMA-b-PDMAEMA-grafted Magnetic Nanoparticles Prepared via Atom Transfer Radical Polymerization[J],CHINESE JOURNAL OF CHEMICAL ENGINEERING,2014,22(11-12):1333-1339 Hao, Wenbo,Ji, Fangling,Wang, Jingyun,Zhang, Yue,Wang, Tianqi,Bao, Yongming.Biochemical characterization of unusual meso-2,3-butanediol dehydrogenase from a strain of Bacillus subtilis[J],JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2014,109:184-190 包永明,王天琪,姬芳玲.细菌3-羟基丁酮及氧化还原产物代谢的研究进展[J],微生物学杂志,2014,34(4):1-6 王静云,姬芳玲,包永明.Lipase Immobilization onto the Surface of PGMA-b-PDMAEMA-grafted[J],Chinese Journal of Chemical Engineering,2014,22(11):1333-1339 Ji, Fangling,Koharudin, Leonardus M. I.,Jung, Jinwon,Gronenborn, Angela M..Crystal structure of the cataract-causing P23T D-crystallin mutant[J],PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2013,81(9):1493-1498 Ji, Fangling,Jung, Jinwon,Koharudin, Leonardus M. I.,Gronenborn, Angela M..The Human W42R gamma D-Crystallin Mutant Structure Provides a Link between Congenital and Age-related Cataracts[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(1):99-109 Ji, Fangling,Jung, Jinwon,Gronenborn, Angela M..Structural and Biochemical Characterization of the Childhood Cataract-Associated R76S Mutant of Human gamma D-Crystallin[J],BIOCHEMISTRY,2012,51(12):2588-2596 Zhang, Yu,Jiang, Bo,Li, Wenli,Zhou, Cheng,Ji, Fangling,Xie, Qun,Sun, Xiaojiao,An, Lijia,Bao, Yongming.Mechanisms of Analgesic Action of Gln49-PLA(2) from Gloydius ussurensis Snake Venom[J],APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2010,160(3):773-779 窦佳,蔡河,姬芳玲,崔文举,王静云,包永明,安利佳.Gln49-磷脂酶A2基因工程定点突变及酶活性分析[J],中国生物工程杂志,2007,27(5):21-27