Education DSc University of Science and Technology of China (2004) MSc Anhui University, China (2001) BEng QiLu University of Technology, China (1998) Academic and Professional Experience 2020 – Present Associate Professor, Faculty of Health Sciences, University of Macau 2020 – Present Assistant Dean (Student Affairs), Faculty of Health Sciences, University of Macau 2015 – 2020 Assistant Professor, Faculty of Health Sciences, University of Macau 2011 – 2014 Assistant Professor, Linköping University, Sweden Obtained Docent (equivalent to Associate Professor) in 2014.05 2010 – 2011 Visiting Scientist, University of Washington, USA 2009 – 2010 Post-doctoral Fellow, Linköping University, Sweden 2006 – 2009 Post-doctoral Fellow, National University of Singapore 2004 – 2006 Post-doctoral Fellow, Shantou University, China Awards 2022 Incentive Award Scheme for Outstanding Academic Staff, University of Macau 2019 FHS Best Teacher (Excellence in teaching) 2017 Incentive Award Scheme for Outstanding Academic Staff, University of Macau 2003 Donggang Scholarship, University of Science & Technology of China

Synthetic/Analytical Chemistry × Molecular Probes × Bioimaging and Sensing × Nanosensor × Nanomedicine My research focuses on the development of chemical tools for biomedical research: (1) Synthesis of new molecular probes for targeted bioimaging/sensing and monitoring of biological processes; (2) Smart probes for theranostics and visualized therapy; (3) Nanoreactors and nanomedicine; (4) Abiotic synthesis in living systems. Chemistry is the central science. We use the knowledge of chemistry to resolve challenging problems in material sciences with the aim of biomedical applications.

C. Wang, Y. Sun, S. Huang, Z. Wei, J. Tan, C. Wu*, Q. Chen*, X. Zhang*(corresponding author), Self-Immolative Photosensitizers for Self-reported Cancer Phototheranostics, J. Am. Chem. Soc, 2023. https://doi.org/10.1021/jacs.3c01666 D. Zhang, Y. Sun, Z. Wang, F. Liu, X. Zhang*(Corresponding author), Switchable biomimetic nanochannels for on-demand SO2 detection by light-controlled photochromism, Nature Communications 2023, 14:1901. Y. Su, Z. Zhang, L. T. O. LEE, L. Peng, L. Lu,* X. He,* X. Zhang*(corresponding author), “Amphiphilic Dendrimer Doping Enhanced pH-Sensitivity of Liposomal Vesicle for effective co-delivery toward synergistic ferroptosis–apoptosis therapy of Hepatocellular Carcinoma”, Adv. Healthc Mater. 2023, 202202663. L. Zhou, W. Feng, Y. Mao, Y. Chen,* X. Zhang*(corresponding), Nanoengineered Sonosensitive Platelets for Synergistically Augmented Sonodynamic Tumor Therapy by Glutamine Deprivation and Cascading Thrombosis, Bioactive Materials 2023, 24, 26–36. D. Zhang, X. Zhang*(corresponding author), Aquaporin-Inspired CPs/AAO Nanochannels for Effective Detection of HCHO: Importance of Hydrophilic/Hydrophobic Janus for High-Performance Sensing. Nano Letters 2022, 22, 3793−3800. L. Zhou, W. Feng, H. Huang, S. Huang, Q. Chen*(corresponding author), X. Zhang*(corresponding author), Y. Chen*(corresponding author), Targeting Acidogenic Metabolism by Engineering Self-Catalytic siRNA Nanocarriers/Nanocatalysts for Amplified Tumor Apoptosis/Ferroptosis. Nano Today, 2022, 46, 101623. J. Gong, X. Zhang*(corresponding author), Coordination-Based Circularly Polarized Luminescence Emitters: Design Strategy and Application in Sensing, Coord. Chem. Review. 2022, 453, 214329. S. Zhao, M. Liu, Y. Zhang, Z. Zhao, Q. Zhang, Z. Mu, Y. Long, Y. Jiang, Y. Liu, J. Zhang, S. Li,* X. Zhang*(co-corresponding author), Z. Zhang,* Harvesting Mechanical Energy for Hydrogen Generation by Piezoelectric Metal–Organic Frameworks, Materials Horizons. 2022, 9, 1978–1983. C. Wang, W. Wang, J. Tan, X. Zhang*(Corresponding author), D. Yuan,* H-C Zhou,* Coordination-based molecular nanomaterials for biomedically relevant applications, Coord. Chem. Rev. 2021, 438, 213752. J. Gong, R. Huang, C. Wang, Z. Zhao, BZ Tang, X Zhang*(corresponding author), Iodization-enhanced fluorescence and circularly polarized luminescence for dual-readout probe design, Sensors and Actuators B: Chem 2021, 347, 130610. D. Zhang, X. Zhang*(Corresponding author), Bioinspired Solid-State Nanochannels Sensor: From Ionic Current Signals, Current and Fluorescence Dual Signals to Faraday Current Signals, Small 2021, 2100495. S. Zhao, Y. Long, Y. Su, S. Wang, Z. Zhang*, X. Zhang*(Corresponding author), Cobalt-enhanced Mass Transfer and Catalytic Production of Sulfate Radicals in MOF-derived CeO2/Co3O4 Nanoflowers for Efficient Removal of Antibiotics, Small 2021, 2101393. X. Zhang, C. Wang, G. Feng, J. Jiang, J. Hu, A. Rietz, C. Brommesson, X. Zhang*(Corresponding author), Y. Ma, K. Roberg, F. Zhang, H-M. Shen, K. Uvdal, Z. Hu,* Tailorable Membrane-Penetrating Nanoplatform for Highly Efficient Organelle-Specific Localization, Small 2021, 2101440. S. Wang, Z. Sheng,* Z. Yang, D. Hu, D. Hu, X. Long, G. Feng, Y. Liu, Z. Yuan, J. Zhang, H. Zheng, X. Zhang*(corresponding author), Activatable Small-Molecule Photoacoustic Probes that Cross Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer’s Disease, Angew. Chem. Int. Ed. 2019, 58, 12415-12419. (Selected as HOT article) B. Zhang, F. Wang, H. Zhou, D. Gao, Z. Yuan, C. Wu,* X. Zhang*(corresponding author), Polymer Dots Compartmentalized in Liposomes as Photocatalyst for In Situ Hydrogen Therapy, Angew. Chem. Int. Ed. 2019, 58, 2744-2748. (Selected as VIP article) J. Tan, C. Wang, HK Lao, W. Wang,* G. Feng, D. Yuan, C. Wu, X. Zhang*(corresponding author), Spiro[pyrrol-benzopyran] Based Probe with High Asymmetry for Chiroptical Sensing via Circular Dichroism, Chem. Commun. 2019, 55, 7438-7441. G. Feng, B. Zhang, S. Wang, Z. Ding, G. Li, X. Zhang*(corresponding author), Ratiometric ATP Detection on Gliding Microtubules Based on Bioorthogonal Fluorescence Ligation, Sensors and Actuators B: Chem. 2019, 301, 127090. C. Wang, X. Cheng, J. Tan, Z. Ding, W. Wang, D. Yuan, G. Li, H. Zhang*, X. Zhang*(corresponding author), Reductive cleavage of C=C bond as a new strategy to turn on dual fluorescence for effective sensing H2S, Chemical Science 2018, 9, 8369–8374. (2018 Hot Article) G. Feng, B. Zhang, C. Wang, J. Tan, S. Wang, Z. Ding, X. Zhang*(corresponding author), Construction of Ratiometric Fluorescent Probe Based on Inverse Electron-demand Diels–Alder Reaction for pH Measurement in Living Cells, Sensors and Actuators B: Chem 2018, 277, 320-327. S. Wang, Z. Li, Y. Liu, G. Feng, J. Zheng,* Z. Yuan,* X. Zhang* (corresponding author), Activatable Photoacoustic and Fluorescent Probe of Nitric Oxide for Cellular and in Vivo Imaging, Sensors and Actuators B: Chem 2018, 267, 403-411. Z. Ding, J. Tan, G. Feng, Z. Yuan, C. Wu, X. Zhang*(corresponding author), Nanoscale Metal-Organic Frameworks Coated with Poly(vinyl Alcohol) for Ratiometric Peroxynitrite Sensing through FRET, Chemical Science 2017, 8, 5101-5106. C-S Ke, C-C Fang, J-Y Yan, P-J Tseng, J R Pyle, C-P Chen, S-Y Lin, J Chen, X. Zhang*(co-corresponding author), Y-H Chan,* Molecular Engineering and Design of Semiconducting Polymers to Develop Polymer Dots with Narrow-Band, Near-Infrared Emission for In Vivo Biological Imaging, ACS Nano, 2017, 11, 3166-3177. X. Zhang*(corresponding author), W. Wang, Z. Hu, G. Wang, K. Uvdal,* Coordination polymers for energy transfer: preparations, properties, sensing applications, and perspectives, Coord. Chem. Rev. 2015, 284, 206-235. X. Zhang,† J. Yu†(co-first author), Y. Rong, F. Ye, D. T. Chiu, K. Uvdal, High-intensity near-IR fluorescence in semiconducting polymer dots achieved by cascade FRET strategy, Chemical Science 2013, 4, 2143-2151. X. Zhang, J. Yu, C. Wu, Y. Jin, F. Ye, D. T. Chiu, Importance of having low-density functional groups for generating high-performance semiconducting polymer dots, ACS Nano 2012, 6, 5429-5439. X. Zhang, MA Ballem, Z-J Hu, P. Bergman, K. Uvdal, Nanoscale Light-harvesting Metal-organic Frameworks, Angew. Chem. Int. Ed. 2011, 50, 5729-5733. X. Zhang, MA Ballem, M Ahrén, A Suska, P Bergman, K Uvdal, Nanoscale Ln(III)-carboxylate Coordination Polymers: Temperature-Controlled Encapsulation and Light Harvesting, J. Am Chem. Soc. 2010, 132, 10391-10397. X. Zhang, Z-K Chen, KP Loh, Coordination-Assisted Assembly of 1-D Nanostructured Light-Harvesting Anntea, J. Am. Chem. Soc. 2009, 131, 7210–7211. X. Zhang, X. Ren, Z-K Chen, Q-H Xu, KP Loh, One- and Two-photon Fluorescent Probe for Cysteine and Homocysteine with Large Emission Shift, Org. Lett. 2009, 11, 1257–1260. X. Zhang, D. Li, Metal Salts Induced Vesicles as Efficient Directors for Rapid Synthesis of Hollow Alloy Spheres, Angew. Chem. Int. Ed. 2006, 45, 5971–5974.