Academic Qualifications Ph.D. (2007) in Organic Chemistry, Queen’s University, Canada Advisor: Prof. Donal H. Macartney, Professor of Chemistry B.Sc. (2002) in Chemistry (Gifted Class), Jilin University, China Advisor: Prof. Bai Yang, Professor of Chemistry and Materials Science Working Experience Aug 2019-Present, Associate Professor of Supramolecular Pharmaceutics and Nanomedicine, Institute of Chinese Medical Sciences,University of Macau, Taipa, Macau SAR, China Oct 2014-Aug 2019, Assistant Professor of Supramolecular Pharmaceutics and Nanomedicine, Institute of Chinese Medical Sciences,University of Macau, Taipa, Macau SAR, China Nov 2009-Oct 2014, Senior Scientist, BTG plc. (Canadian branch, formerly a part of Nordion Inc., now part of Boston Scientific), Ottawa, Canada May 2008–Nov 2009, Associate Research Officer (started as a Research Associate) at Steacie Institute for Molecular Sciences,National Research Council of Canada, Ottawa, Canada Aug 2007-May 2008, Postdoctoral Fellow, Department of Chemistry at Queen’s University, Canada

Supramolecular Pharmaceutics/Medicine We are interested in supramolecular interactions between macrocyclic molecules (such as cucurbiturils, cyclodextrins, pillararenes and calixarenes) and synthetic/natural drugs, with intentions to explore the beneficial roles of these macrocycles as emerging excipients for enhancing water solubility, stability, transcellular activity, and ultimately therapeutic efficacy with reduced side effects of guest medicines. In many cases, these macrocycles may act as reversal agents (or antidotes) towards toxic effects of guest drugs. Our collaborators include colleagues here at UM, as well as external scientists from Canada, France, USA, Hong Kong and mainland China. Supramolecular Biomaterials We intend to incorporate high potency ingredients (e.g. particularly those of natural products) into stimuli-responsive supramolecularly self-assembled materials for various biomedical applications such as precision medicine, controlled drug release and interventional medicine for targeted therapy. These material matrices include natural polysaccharides, natural and synthetic macrocycles and their derivatives. By placing real-world clinical applications as our study aim, we work closely with scientists and clinicians in the region and around the world. Biomimetic Drug Delivery and Cytopharmaceuticals Constantly inspired by Nature and ancient principles of Chinese medicine, we are highly interested in developing biomimetic drug delivery systems and cytopharmaceuticals, particularly those based on supramolecular assembly, for improved therapeutics in a variety of diseases, such as inflammatory diseases, infections and cancers.

Mian Tang, Zhiqing Yang, Xingchen Tang, He Ma, Beibei Xie, Jiang-Fei Xu, Cheng Gao*, David Bardelang, Ruibing Wang*, “Hypoxia-initiated supramolecular free radicals induce intracellular polymerization for precision tumor therapy,” Journal of the American Chemical Society, 2025, DOI: 10.1021/jacs.4c14847. Qun Guan, Le-Le Zhou, Zhiqing Yang, Beibei Xie, Yan-An Li, Ruibing Wang*, “An sp2 Carbon-Conjugated Covalent Organic Framework for Fusing Lipid Droplets and Engineered Macrophage Therapy,” Angewandte Chemie International Edition, 2024, DOI:10.1002/anie.202421416 Junyan Li,, Ziyi Wang,, Ruifeng Luo, Xingping Quan, Hong U Fong, Qian Cheng, Jianwen Wei, Leo Wang, Yonghua Zhao, Ruibing Wang* ,”Tumor Microenvironment Triggered in-situ Coagulation of Supramolecularly Engineered Platelets for Precise Tumor Embolization,” Advanced Science, 2025. Zeyu Wang, Zhiqing Yang, Sen Li, Cheryl H.T. Kwong, Daiyan Zhang, Jianwen Wei, Cheng Gao, Qing-wen Zhang*, Ruibing Wang*, “Light-Directed Microalgae Micromotor with Supramolecular Backpacks for Photodynamic Therapy,” Advanced Functional Materials, 2025. Ziyi Wang, Jianwen Wei, Ruibing Wang*, “Backpacked Neutrophils via Noncovalent Interactions: A Candidate for Nova Cell Therapy,” Matter, 2024, 7, 2800-2803. Ruifeng Luo, Jinwei Liu, Qian Cheng, Mitsuhiko Shionoya, Cheng Gao*, and Ruibing Wang*, “Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis,” Science Advances, 2024,10, eado6798. Cheng Gao, Qingfu Wang, Yuan-Fu Ding, Cheryl Kwong, Jinwei Liu, Beibei Xie, Jianwen Wei, Simon Lee, Greta Mok, Ruibing Wang*, “Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats,” Nature Communications, 2024, 15, 328. Mian Tang, Tianshun Duan, Yunfeng Lu, Jinwei Liu, Cheng Gao*, Ruibing Wang*, “Tyrosinase-Woven Melanin Nets for Melanoma Therapy through Targeted Mitochondrial Tethering and Enhanced Photothermal Treatment,” Advanced Materials, 2024, 36, 2411906. Hang Yin, Roselyne Rosas, Stéphane Viel, Michel Giorgi, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Youssef Nassar, Floris Chevallier, Christophe Bucher*, Ruibing Wang*, Anthony Kermagoret*, David Bardelang*, “Internal Dynamics and Modular Peripheral Binding in Stimuli-Responsive 3:2 Host:Guest Complexes,” Angewandte Chemie International Edition, 2024, 63, e202315985. Ziyi Wang, Chen Sun, Yu Dong, Yuan-Fu Ding, Chen Zhao, Ian Wa Ho, Jiahong Lu*, Ruibing Wang*, “Supramolecular Manipulation of Intracellular Acidic Vesicles to Improve Cellular Self-repairs and Self-defense,” CCS Chemistry, 2024, 6, 1487–1498. Qian Cheng, Xingping Quan, Ruifeng Luo, Zhiqing Yang, Junyan Li, Ziyi Wang,Yonghua Zhao, Chunhai Fan, and Ruibing Wang*, “In Situ Colonization of Trojan-Yeast for Targeted GlucoseStarvation and Reconstruction of Tumor ImmuneEnvironment,” Advanced Functional Materials, 2024, 34，2316701. Kui He, Yuanfu Ding, Zhipeng Zhao, Ben Liu, Wenyan Nie, Xiaoxi Luo, Hua Zhong Yu, Jinbin Liu*, Ruibing Wang*, “Cucurbit[7]uril-Mediated Organ-Specific Delivery of Ultrasmall NIR-II Luminescent Gold Nanocarriers for Therapy of Acute Kidney Injury,” Advanced Functional Materials, 2024, 34, 2309949. Xingping Quan, Chang Liu, Jinfen Chen, Yiyang Li, Zhen Yuan, Ying Zheng, Greta SP Mok, Ruibing Wang*, Yonghua Zhao* , “Neutrophil-mimetic upconversion photosynthetic nanosystem derived from microalgae for targeted treatment of thromboembolic stroke,” ACS Nano, 2024, 18, 30307–30320. Junyan Li, Yuan-Fu Ding, Ziyi Wang, Qian Cheng, Jianwen Wei, Zhiqing Yang, Ruibing Wang*, “TAM-preferential nanoparticles intracellularly self-assembled for enhanced macrophage repolarization and cancer immunotherapy,” Nano Today, 2024, 54, 102104. Kui He, Chao Hu, YuanFu Ding, Wei Cai, Di Huang, Luoqi Mo, Jinbin Liu*, Ruibing Wang*, “Renal-clearable luminescent gold nanoparticles incorporating active and bio-orthogonal tumor-targeting for drug delivery and controlled release,” Nano Today, 2024, 56, 102245. Ludan Yue, Guocan Yu, Lang Rao*, Ruibing Wang*, Xiaoyuan Chen*, “Supramolecular Aggregates and Hitchhikers,” Accounts of Materials Research, 2024, 5, 1237–1250. Cheng Gao, Cheryl H.T. Kwong, Mian Tang, Jinwei Liu, Hiotong Kam, Shengke Li, Simon M. Y. Lee, Chunhai Fan, Hua-Zhong Yu, Ruibing Wang*, “A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection,” Matter, 2023, 6, 3889-3911. Highlighted by Zhao et al, Matter, 2023, 6, 3695-3698. Ludan Yue, Cheng Gao, Junyan Li, Hanbin Chen, Simon M. Y. Lee, Ruifeng Luo, Ruibing Wang*, “Chemotaxis-guided self-propelled macrophage motor for targeted treatment of acute pneumonia,” Advanced Materials, 2023, 35, 2211626. Meng Xu, Haidong Zha, Jiamao Chen, Simon Ming-Yuen Lee, Qi Wang*, Ruibing Wang*, Ying Zheng*, “Ice & Fire” Supramolecular Cell-Conjugation Drug Delivery Platform for Deep Tumor Ablation and Boosted Anti-Tumor Immunity,” Advanced Materials, 2023, 35, 2305287. Beibei Xie, Huichao Zhao, Yuanfu Ding, Ziyi Wang, Cheng Gao, Shengke Li,Kehan Zhang, Seong Wan Ip, Huazhong Yu, Ruibing Wang*, “Supramolecularly Engineered Conjugate of Bacteria and CellMembrane-Coated Magnetic Nanoparticles for EnhancedFerroptosis and Immunotherapy of Tumors,” Advanced Science, 2023, 10, 2304407. Cheng Gao, Cheryl H.T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Simon Ming-Yuen Lee, Guosong Chen, Ruibing Wang*, “Conjugation of macrophage-mimetic microalgae and liposome for antitumor sonodynamic immunotherapy via hypoxia alleviation and autophagy inhibition,” ACS Nano, 2023, 17, 4034-4049. Xingping Quan, Xiao Liang,Yuanfu Ding, Yan Han, Junyan Li, Mengchen Yuan, Yiyang Li, Zhen Yuan, Ruibing Wang,* Yonghua Zhao* “Cryo-shocked platelet coupled with ROS-responsive nanomedicine for targeted treatment of thromboembolic disease,” ACS Nano, 2023, 17, 6519–6533. Hang Yin, Qian Cheng, David Bardelang,* Ruibing Wang,* “Challenges and opportunities of functionalized cucurbiturils for biomedical applications,” JACS Au, 2023, 3, 2356-2377. Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H.T. Kwong, Jianwen Wei, Beibei Xie, Siyu Lu, Simon M. Y. Lee,* and Ruibing Wang,* “In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma,” Science Advances, 2022, 8, eabn1805. Selected as Science Advances feature article (with artworks showcased online). Ziyi Wang, Chen Sun, Kuikun Yang, Xiaoyuan Chen* and Ruibing Wang*, “Cucurbituril-Based Supramolecular Polymers for Biomedical Applications,” Angewandte Chemie International Edition, 2022, 61, e2022067. Kuikun Yang, Zhiqing Yang, Guocan Yu*, Zhihong Nie*, Ruibing Wang*, Xiaoyuan Chen*,“Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy,” Advanced Materials, 2022, 34, 2107434. Ludan Yue, Kuikun Yang, Jianwen Wei, Mengze Xu, Chen Sun, Yuanfu Ding, Zhen Yuan, Shu Wang* and Ruibing Wang* “Supramolecular vesicles based on gold nanorods for precise control of gene therapy and deferred photothermal therapy,” CCS Chemistry, 2022, 4, 1745-1757. Yan-Long Ma, Chen Sun, Zeshun Li, Ziyi Wang, Jianwen Wei, Qian Cheng, Li-Shuo Zheng, Xiao-Yong Chang, Kai Li, Ruibing Wang* & Wei Jiang* “Biomimetic Recognition-Based Bioorthogonal Host–Guest Pairs for Cell Targeting and Tissue Imaging in Living Animals,” CCS Chemistry, 2022, 4, 1977-1989. Cheng Gao, Cheryl H.T. Kwong, Qingfu Wang, Hiotong Kam, Jianwen Wei, Qian Chen, Jian Zhang, Simon M. Y. Lee,* Dayong Gu and Ruibing Wang,*,“Surface-engineered chlorella alleviated hypoxic tumor microenvironment for enhanced chemotherapy and immunotherapy of first-line drugs,” Materials Today, 2022, 58, 57-70. Shuwen Guo, Qiaoxian Huang, Jianwen Wei, Shengpeng Wang, Yitao Wang, Leyong Wang, and Ruibing Wang,*,“Efficient Intracellular Delivery of Native Proteins Facilitated by Preorganized Guanidiniums on Pillar[5]arene Skeleton,” Nano Today, 2022, 43, 101396. Selected as a front cover article. Meng Xu, Jinsong Tao, Zhengjie Wei, Qian Cheng, Hongmei Yang, Simon Ming-Yuen Lee, Kathy Qian Luo, Wei Ge, Ruibing Wang,* and Ying Zheng,*,“Visualization of host-guest interactions driven bioorthogonal homing effects at the single cell level in vivo,” Nano Today, 2022, 43, 101450. Qian Cheng, Meng Xu, Chen Sun, Kuikun Yang, Zhiqing Yang, Junyan Li, Jun Zheng, Ying Zheng and Ruibing Wang*,“Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage),” Materials Horizons, 2022, 9, 934-941. Selected as a front cover article. Beibei Xie, Huichao Zhao, Mingju Shui, Yuan-Fu Ding, Chen Sun, Ziyi Wang, Cheng Gao, Guosong Chen, Ruibing Wang,* “Spermine-Responsive Intracellular Self-Aggregation of Gold Nanocages for Enhanced Chemotherapy and Photothermal Therapy of Breast Cancer,” Small, 2022, 18, 2201971. Selected as an inside back cover article. Meng Xu, Haidong Zha, Run Han, Yaxin Cheng, Jiamao Chen, Ludan Yue, Ruibing Wang* and Ying Zheng,* “Cyclodextrin-derived ROS-generating nanomedicine with pH-modulated degradability to enhance tumor ferroptosis therapy and chemotherapy,” Small, 2022, 18, 202200330. Kuikun Yang, Guocan Yu, Zhiqing Yang, Ludan Yue, Xiangjun Zhang, Chen Sun, Jianwen Wei, Lang Rao, Xiaoyuan Chen,* and Ruibing Wang,* “Supramolecular Polymerization-induced Nanoassemblies for Self-augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor,” Angewandte Chemie International Edition, 2021, 60, 17570-17578. Shuwen Guo, Qiaoxian Huang, Yuan Chen, Jianwen Wei, Jun Zheng, Leyong Wang, Yitao Wang and Ruibing Wang,* “Synthesis and Bioactivity of Guanidinium‐Functionalized Pillar[5]arene as a Biofilm Disruptor,” Angewandte Chemie International Edition, 2021, 60, 618-623 (Selected as “Hot Paper” and Frontipiece story). Xue Yang, Qian Cheng, Valerie Monnier, Laurence Charles, Hakim Karoui, Olivier Ouari, Didier Gigmes, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Guest exchange by a partial energy ratchet in water,” Angewandte Chemie International Edition, 2021, 60, 6617–6623. Cheng Gao, Qian Cheng, Junyan Li, Jia Chen, Qingfu Wang, Jianwen Wei, Qiaoxian Huang, Simon M. Y. Lee,* Dayong Gu,* Ruibing Wang,* “Supramolecular macrophage-liposome marriage for cell-hitchhiking delivery and immunotherapy of acute pneumonia and melanoma,” Advanced Functional Materials, 2021, 31, 2102440. Kuikun Yang, Guocan Yu, Rui Tian, Zijian Zhou, Hongzhang Deng*, Ling Li, Zhen Yang, Guofeng Zhang, Dahai Liu, Jianwen Wei, Ludan Yue, Ruibing Wang,* and Xiaoyuan Chen,* “Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy,” Advanced Functional Materials, 2021, 31, 2008078. Kuikun Yang, Ludan Yue, Zhiqing Yang, Guocan Yu, Lang Rao, Rui Tian, Jianwen Wei, Chen Sun, Xiangjun Zhang, Mengze Xu, Zhen Yuan, Xiaoyuan Chen,* and Ruibing Wang,* “A Hypoxia Responsive Nanoassembly for Tumor Specific Oxygenation and Enhanced Sonodynamic Therapy,” Biomaterials, 2021, 275, 120822. Qian Cheng, Ludan Yue, Junyan Li, Cheng Gao, Yuanfu Ding, Chen Sun, Mengze Xu, Zhen Yuan, and Ruibing Wang,* “Supramolecular tropism driven aggregation of nanoparticles in situ for tumor-specific bioimaging and photothermal therapy,” Small, 2021, 17, 202101332. Ludan Yue, Kuikun Yang, Junyan Li, Qian Cheng and Ruibing Wang* “Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy,” Small, 2021, 17, 202102286. Chen Sun, Ziyi Wang, Kuikun Yang, Ludan Yue, Qian Cheng, Yan-long Ma, Siyu Lu, Guosong Chen, and Ruibing Wang,* “Polyamine-responsive Morphological Transformation of a Supramolecular Peptide for Specific Drug Accumulation and Retention in Cancer Cells,” Small, 2021, 17, 202101139. Hang Yin, David Bardelang* and Ruibing Wang,* “Macrocycles and Related Hosts as supramolecular antidotes,” Trends in Chemistry, 2021, 3, 1-4. Jia Chen, Shengke Li, Zeyu Wang, Yating Pan, Jianwen Wei, Siyu Lu, Qing-Wen Zhang, LianHui Wang and Ruibing Wang,* “Synthesis of AIEgen Functionalized Cucurbit[7]uril for Subcellular Bioimaging and Synergistic Photodynamic Therapy and Supramolecular Chemotherapy“, Chemical Science, 2021, 12, 7727-7734. Selected as a Chem Sci Pick! Hang Yin, Xiangjun Zhang, Jianwen Wei, Siyu Lu, David Bardelang,* and Ruibing Wang,* “Recent advances in supramolecular antidotes,” Theranostics, 2021, 11, 1513-1526. Chen Sun, Ziyi Wang, Ludan Yue, Qiaoxian Huang, Qian Cheng and Ruibing Wang,* “Supramolecular Induction of Mitochondrial Aggregation and Fusion,” Journal of the American Chemical Society, 2020, 142, 16523–16527. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jian-Bo Wan, Simon M. Y. Lee* and Ruibing Wang,* “Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines,” Nature Communications, 2020, 11, 2622. Highlighted by Nature Review Cardiology, 2020, https://doi.org/10.1038/s41569-020-0404-x. Ludan Yue, Kuikun Yang, Xin-Yue Lou, Ying-Wei Yang* and Ruibing Wang,* “Versatile roles of macrocycles in organic-inorganic hybrid materials for biomedical applications,” Matter, 2020, 3, 1557–1588. Xue Yang, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Oligomeric Cucurbituril Complexes: from Peculiar Assemblies to Emerging Applications,” Angewandte Chemie International Edition, 2020, 132, 21464 – 21476. Cheng Gao, Qian Cheng, Jianwen Wei, Chen Sun, Siyu Lu, Cheryl H.T. Kwong, Simon M.Y. Lee, Zhiyuan Zhong* and Ruibing Wang,* “Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery,” Materials Today, 2020, 40, 9-17 (selected as a featured inside cover). Yan-Long Ma, Mao Quan, Xiu-Lian Lin, Qian Cheng, Huan Yao, Xi-Ran Yang, Ming-Shuang Li, Wei-Er Liu, Lin-Ming Bai, Ruibing Wang,* and Wei Jiang,* “Biomimetic Recognition of Organic Drug Molecules in Water by Amide Naphthotubes,” CCS Chemistry, 2020, 2, 1078-1092. Qiaoxian Huang, Hong Zhao, Mingju Shui, Dong-Sheng Guo* and Ruibing Wang,* “Heparin Reversal by an Oligoethylene Glycol Functionalized Guanidinocalixarene,” Chemical Science, 2020, 11, 9623-9629. Tianlei Sun, Cheryl H. T. Kwong, Cheng Gao, Jianwen Wei, Ludan Yue, Jianxiang Zhang, Richard Dequan Ye* and Ruibing Wang,* “Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine,” Theranostics, 2020, 10, 10106-10119.