研究生培养

研究生培养是我们的重要任务。我们欢迎对制药工程、药物化学、化学生物学、化学和制药学具有浓厚兴趣、基础知识扎实、并乐于勤奋钻研的学生加入我们，欢迎药学类、化学化工以及生命科学类和医学类来源的考生报考。本人具有企业、研究所、高校和海外进修经历，具有教授，研究员和研究员高级工程师三大系列（教学、研究和工程）正高级职称。热忱欢迎与我们直接联系进行相关咨询答疑（徐德锋markxu@cczu.edu.cn），你们的致电是我们的荣幸。我们以努力创造条件，培养优秀的科研人才为己任。

RESEARCHINTERESTS(研究方向):

1.Drugdiscoveryofanti-androgenreceptorandstudyonthemechanismoftreatmentofadvancedprostatecancer;

(新型抗雄激素受体和抗晚期前列腺癌机制研究)

2.Designandsynthesisofsmallmoleculeswithimportantbiologicalactivities.

(药物设计、合成生物活性分子)

3.CleanTechnologyIndustrializationResearchinChemicalengineering

（清洁工艺生产技术产业化研究）

4.Researchongreenherbicideinnovationandindustrializationofnewtechnology

（绿色除草剂创新及新技术产业化）

PROFESSIONALEXPERIENCE(工作经历):

2017-2018,VisitingProfessor,RochesterUniversity,NewYork,USA.

(美国罗切期特大学，访问教授)

2013-Present,ProfessorofPharmacy,ResearcherofPharmaceuticalEngineer,

SchoolofPharmaceuticalandLifeSciences,ChangzhouUniversity,China.

(常州大学制药与生命科学学院，，教授/团队负责人)

2012-Present,Researcher，CEO,NanjingHope-pharmCo.Ltd,China.

(南京慧博生物科技有限公司，，董事长/研究员)

2006-2012,ResearcherofPharmaceuticalEngineer,AssociateProfessorofPharmacy,SchoolofPharmacy,ShanghaiJiaoTongUniversity,China.

(上海交通大学药学院，，副研究员/研究员级高工)

2009-2011,visitingScholar,Post-doctoralFellow,

MedicalCenter,RochesterUniversity,NewYork,USA

(美国罗切期特大学医学研究中心，博士后/访问学者)

2001-2003,SeniorEngineer,SeniorGroupLeader,JinTanWishchemCo.,Ltd

（金坛希望化工有限公司，总经理/高级工程师）

1992-2000,ChemicalEngineer,JiangsuInstituteofEcomones

（江苏激素研究所，工程师）

1990-1992,EngineerAssistant,FushunPetroleum&ChemicalCorporationofChina

（中国石化公司抚顺分公司，助理工程师）

EDUCATIONBACKGROUND(教育背景):

2006,Ph.D.(Major:MedicineChemistry),ShanghaiJiaoTongUniversity,China.

(上海交通大学，药物化学博士)

2000,M.S.(Major:ApplyChemistry),NanjingUniversityofScience&Technology,

(南京理工大学，应用化学工程硕士)

1990,B.S.(Major:OrganicChemistry),JiangsuPolytechnicUniversity,China

(江苏化工学院，有机化工本科)

TEACHINGEXPERIENCE(授课经历):

“PharmaceuticalEngineering制药工程”(forundergraduatestudents,2013-2019),ChangzhouUniversity,China.

“IntroductiontoPharmaceuticalEngineering制药工程专业概论”(forundergraduatestudents,2013-2016),ChangzhouUniversity,China.

“Pharmaceuticalpreparationengineering药物制剂工程”(forgraduatestudents,2013-2016)ChangzhouUniversity,China.

“Experimentofmedicinechemistry药物化学实验”(forundergraduatestudents,2006-2012),ShanghaiJiaoTongUniversity,China.

“TotalSynthesisofNaturalProducts天然产物全合成”(forgraduatestudents,2006-2012),ShanghaiJiaoTongUniversity,China.

AWARDSANDRECOGNITIONS(获奖荣誉):

1.TheHouDebangChemicalScience&TechnologyInnovationAwardofChinaChemicalIndustryInstitute(2019)

(2019年侯德榜化工科技创新奖)

2.SilverPrizesinthe5thChinaCollegeStudents’Internet+innovationandentrepreneurshipcompetition(instructor,2019）

(第五届中国“互联网+”大学生创新创业大赛全国总决赛银奖)

3.GoldPrizesinCollegeStudents’Internet+innovationandentrepreneurshipcompetitioninJiangsu,Thirdplace,targetedpovertyalleviationAward((instructor,2019）

(第五届中国“互联网+”大学生创新创业大赛江苏决赛一等奖，决赛季军，精准扶贫奖)

4.SecondPrizeofInventionandEntrepreneurshipAchievementAward,ChinaAssociationofInventions(2019)

(中国发明协会发明创业成果奖二等奖）

5.Thirdawardofscientificandtechnologicalinnovationachievements，ChinaprivatescienceandTechnologyPromotionAssociation（2019）

(优秀民营科技创新成果三等奖，中国民营科技促进会)

6.ChinaIndustry-University-ResearchCooperationInnovationAward(2018)

（2018年中国产学研合作创新奖）

7.TheScientificChinese(2017)personoftheYearAward(2018)

科学中国人（2017）年度人物奖

8.ExcellentScienceWorkersinChemicalIndustryProductivityPromotionCenterofChina(2018)

(2018年度全国石油和化工优秀科技工作者）

9.Secondawardofscientificandtechnologicalinnovationachievements，ChinaprivatescienceandTechnologyPromotionAssociation（2017）

(优秀民营科技创新成果二等奖，中国民营科技促进会)

10.Theoutstandingachievementaward,ChinaIndustry-University-ResearchInstituteCollaborationAssociation(2017)

(优秀成果奖，中国产学研合作促进会)

11.ThescienceandtechnologyentrepreneursofNanjing(2016)

(南京市科技创业家)

12.High-LevelEntrepreneurialandInnovativeTalentsofJiangsuProvince(2015)

(江苏省“双创人才”)

13.Invention&EntrepreneurshipAward,ChinaAssociationofInventions（2014）

(中国发明协会，发明创业奖-人物奖)

14.ThirdawardofTechnicalinvention,ChinaPetroleum&ChemicalIndustryFederation(2014)(科技发明三等奖,中国石油与化工联合会)

15.LeadingEntrepreneurialandHigh-techTalentsofNanjing(2012)

（南京市321引进人才）

16.ThirdAwardofScienceandtechnologyprogress,ShanghaiPharmaceuticalAssociation(2010).(科技进步三等奖，上海药学会)

17.SecondAwardofTeachingAchievement,ShanghaiJiaoTongUniversity(2012)

(教学成果二等奖，上海交通大学)

18.SecondAwardofScienceandtechnologyprogress,ChinaPetroleum&ChemicalIndustryFederation(2009)，(科技进步二等奖,中国石油与化工联合会)

19.StarofOutlookAwardforYoungScholarsofShanghaiJiaoTongUniversity(2008)

(晨星青年学者二等奖，上海交通大学)

20.ThirdAwardofthePaperofMedicinalChemistryConference,ShanghaiPharmaceuticalAssociation(2005),(科技论文三等奖，上海药学会)

21.ThirdawardofNo.4ZhouPaiyuan(HP)awardedbyMinistryofCommerceofChina.(1998),(HP应用成果奖三等奖,中国经贸部)

FUNDINGS(基金课题):

1.High-levelEntrepreneurialandInnovativeTalentTeamofJiangsuProvince(2017)“Studyoninnovation,industrializationandApplicationofGreenHerbicides”(2017-2020,PI).

江苏省“双创团队”基金，“绿色除草剂创新、创制及新技术应用研究”，（2017-2022，主持)。

2.AlevelInnovativeprojectofTaizhou“500ElitePlan”inZhejiang(2018)“TheIndustrializationofgreenpreparationofhighefficiencyherbicidePyribenzoxim”(2018-2021,PI)).

浙江省台州市“500精英计划”-A类创业基金，“高效除草剂嘧啶肟草醚绿色制造技术产业化”，（2018-2021，主持)。

3.NorthJiangsuDistrictScienceandTechnologySpecialFund,(No.:SZ-YC2017038),StudyonintegrationanddemonstrationofcultivationtechniquesofGanodermaluciduminsaline-alkaliland,(2017-2019,CO-PI).

江苏省科技厅苏北科技专项，(基金号:SZ-YC2017038):“盐碱地灵芝栽培种植技术集成与示范应用研究”，（2017-2019，共同主持)。

4.ChangzhouScienceandTechnologyDevelopmentFunds,(FundsNo:CE20162015)“StudyonIndustrializationandApplicationofKeyTechnologyofPyribenzoxim”(2016-2018,PI)).

常州市科技支撑计划,(基金号:CE20162015):“高效绿色除草剂嘧啶肟草醚关键技术产业化及应用研究”，（2016-2017,主持)。

5.TheJiangsuProvincescienceandtechnologySMEtechnologyinnovationfundproject(grantNo.BC2014026)“R&DofModernmedicineacnefunctionallyactivemolecularandfunctionalcosmetics”(2014-2016,PI)

江苏省科技型中小企业技术创新资金(代号BC2014026)：“现代中药祛痘功能活性分子及功能化妆品研发”(2013-2016,主持)。

6.OverseasEntrepreneurialTalentsofJiaxing.AlevelInnovativeproject“industrializationofNano-molecularbiologicalactivityandfunctionalcosmetics”(2014-2016,PI)

浙江省嘉兴市“创新嘉兴·精英引领计划”A类创业基金：“生物靶向纳米分子活性研究及功能化妆品产业化”(2014-2016,主持)。

7.High-techleadingtalentsofChangzhouC-specialInnovativeproject“StudyontheNovelAnti-androgenforTreatmentofProstateCancerandIndustrializationofNatureGoodFoodfortheProstateHealth”(2014-2016,CO-PI)

江苏常州市“龙城英才计划”C类特别创业基金：“新型雄激素受体药物的创制研究及前列腺保健食品技术产业化”(2014-2016,共同主持)。

8.LeadingEntrepreneurialandHigh-techTalentsofNanjingInnovativeproject“IndustrializationofBispyribacsodium,aHerbicidewithHigh-efficiencyandLowToxicity”(2013-2015,PI)

江苏南京市321人才创新创业基金：“高效低毒水稻田除草剂双草醚新技术成果转化”(2013-2015,主持)。

9.Sino-USAinternationalcollaborativeproject:“PreclinicalResearchonaNovelAnti-androgenASC-J9”(2013-2016,CO-PI)).

国际合作项目:“国家一类新药ACS-J9临床前研究”(2013-2016,共同主持)。

10.ShanghaiMinghangScienceandTechnologyDevelopmentFunds,(FundsNo:2012MH166)“D&RonSIOC-Y-047,aNovelOxadiazineInsecticide”(2012-2015,CO-PI)).

上海市闵行基金,(基金号:2012MH166):“噁二嗪类杀虫剂SIOC-Y-047创制研究，（2012-2015,共同主持)。

SELECTEDPUBLICATIONS(学术论文):

1.DefengXu*,H.Hu,J.G,J.Da,YP.Xie,YL.Li,R.Kong,GQ.Song,H.Zhou.,SynthesisofNovelTanshinoneDerivativesTargetingAndrogenReceptorforTreatmentofCastration-resistantProstateCancer.ChemBiolDrugDes.201994(3):1656-1663.doi:10.1111/cbdd.13567.

2.HangHu,HuanZhou,ZihanZhen,ZheWu,RongZhang,andDefengXu*,Methoxylpoly(ethyleneglycol)-retinoicacidMicellesLoadedwithDimethylcurcuminforEfficientCastrationResistantProstateCancerTherapy,ChemistrySelect.2019,4,12015–12021.

3.BinWang,XiangjianXu,ShunzeGong,QinWang,HangHu*,DefengXu*,SynthesisandHerbicidalActivityofO-(2,6-Bis(4,6-dimethoxypyrimidin-2-yloxy)benzoyl)oxime3-Trifluoromethylacetophenone.ChemistrySelect.2019,4,11771–11775.

4.HuH,WangB,LaiC,XuX,ZhenZ,ZhouH,DefengXu*,iRGD-paclitaxelconjugatenanoparticlesfortargetedpaclitaxeldelivery.DrugDevRes.2019,1-9.doi:10.1002/ddr.21589.

5.ZhouH,LiuYL,LvL,WangWJ,HuH,YangL,DefengXu*.Designandevaluationofasoliddispersionandthermosensitivehydrogelcombinedlocaldeliverysystemofdimethoxycurcumin.JournalofDrugDeliveryScienceandTechnology,2019,53.UNSP101150.DOI:10.1016/j.jddst.2019.101150

6.LZhang,SBCheng,HHu,DefengXu*,AFacileSynthesisof3-(Chloromethyl)-methyl-1,1′-biphenyl,AsianJ.Chem.2019,31(12):3009-3011.

7.H.Zhou,WJ.Wang,H.Hu,X.Ni,S.Ni,Y.Xu,L.Yang,DefengXu*,Co-precipitationofcalciumcarbonateandcurcumininanethanolmediumasanovelapproachforcurcumindissolutionenhancement.JournalofDrugDeliveryScienceandTechnology,2019,19,4-8.

8.DefengXu,WJWang,MMYang,SBBhaduri,CCHuang,LYang,ZYiZhang,HZhou*.Applicationofbeta-CD/HAcompositeasapotentialSDcarriertoimprovethedissolutionofcurcumin.Micro&NanoLetters,2019,14(40):353-8,DOI:10.1049/mnl.2018.5096.

9.DefengXu,YL.Liu,WJ.Wang,H.Zhou*,PreparationandCharacterizationofDimethylcurcuminSolidDispersion.Chin.J.Pharmaceuticals.2019,50(2),75-80.

10.ShenMei-Hua,QuHong-Yu,DaiPing,ZhouHao,LiuTS,BaoXiaoguang,XuDefeng,XuHua-Dong.IntramolecularImino-eneReactionofAzirines:Regioselectivity,Diastereoselectivity,andComputationalInsights.JOURNALOFORGANICCHEMISTRY.2019,,84(7):4095-4103.DOI:10.1021/acs.joc.9b00087

11.YP.Bi,HM.Wang,HY.Qu,XC.Liang,Y.Zhou,XY.Li,DefengXu,MH.Shen*,HD.Xu*,Stereoselectivesynthesisofall-cisboryltetrahydroquinolinesviacopper-catalyzedregioselectiveaddition/cyclizationofo-aldiminylcinnamatewithB(2)Pin(2).Org.Biomol.Chem.,2019,17,1542–1546.

12.HuangXiu-Rong,ZhangYu-Mei,WanTing-Biao,ZhangPiao,ZhangXiu-Xiu,WangFang-Ming,XuDefeng,ShenMei-Hua,XuHua-Dong.Straightforwardsynthesisof4,5-bifunctionalized1,2-oxazinanesviaLewisacidpromotedregio-andstereo-selectivenucleophilicring-openingof3,6-dihydro-1,2-oxazineoxides.Tetrahedron,2019,75(45):130336.DOI:10.1016/j.tet.2019.05.015.

13.MaxA.Cheng,Fu-JuChou,KeliangWang,RachelYang,JieDing,QiaoxiaZhang,GonghuiLi,ShuyuanYeh,DefengXu*andChawnshangChang*,Androgenreceptor(AR)degradationenhancerASC-J9®inanFDA-approvedformulatedsolutionsuppressescastrationresistantprostatecancercellgrowth.CancerLetters,2018,417:182-191.

14.DefengXu*,XinhongCaiandShunzeGong,Design,SynthesisandEvaluationofInsecticidalActivityofNovelOxadiaz-ineDerivatives.CurrBioactCompd,2018,14,9-20.

15.MengmengYang,FangLiang,DefengXu*,YueWang,HuanZhou*,TeaPolyphenolsSelectivelyInhibitProliferationandMigrationofAirwaySmoothMuscleCells,JournalofBiologyandLifeScience,2018,9(2),39-51

16.HZhou,YPBi,MMYang,WJWang,XYNi,DFXu*.Synthesisofmesoporousmagnesiumphosphatesasdispersingcarriersforcryptotanshinonesoliddispersions.InternationalJournalofAppliedCeramicTechnology.2018,15(4):938-946.

17.DefengXu*,QiuluChen,YalinLiuandXingqiaoWen*,Baicaleinsuppressestheandrogenreceptor(AR)-mediatedprostatecancerprogressionviainhibitingtheARN-CdimerizationandAR-coactivatorsinteraction,Oncotarget,2017,8(62),105561-105573.

18.RuiLi,DefengXu,XingqunYang,ShouxiuMa,XiaoaiGe,ShuwenZhou*,Preparationandstabilitystudiesofdimethylcurcuminniosomes,J.Chin.Pharm.Sci.2017,26(4),265–270.

19.XinhingCai,QiuluChen,JingGuan,ShunzeGong,HaoFuandDefengXu*,AConvenientSynthesisof2-Methoxycarbonyl-5-iodobenzeneSulfonamide,AsianJournalofChemistry;AsianJ.Chem.,2017,29(7),1622-1624.

20.DefengXu*,ShunzeGong,XinhongCai,ConciseandConvenientSynthesisof4-(Trifluoromethylthio)aniline,AsianJ.Chem.,2017,29(11),91-92.

21.DefengXu*,JingGuan,XingXu,ShunzeGongandHuiXu,ANewMethodfortheSynthesisofOxadiazineInsecticideIndoxacarb,J.Heterocyclic.Chem2016,53:1469-1473.

22.QiangDang,WenbinSong,DefengXu,YanminMa,FengLi,JinZeng,XinyangWang,LukeChang,DalinHe,Kaempferolsuppressesbladdercancertumorgrowthbyinhibitingcellproliferationandinducingapoptosis,MOLECULARCARCINOGENESIS,2015,54(9):831-840.

23.WenbinSong,QiangDang,DefengXu,YuleChen,GuodongZhu,KaijieWu,JinZeng,QingzhiLong,XinyangWang,DalinHe,KaempferolinducescellcyclearrestandapoptosisinrenalcellcarcinomathroughEGFR/p38signaling,ONCOLOGYREPORTS,2014,31(3):1350-1356.

24.XuD,LinTH,YehCR,ChengMA,ChenLM,ChangC,YehS.Thewedelolactonederivativeinhibitsestrogenreceptor-mediatedbreast,endometrial,andovariancancercellsgrowth.BiomedResInt.2014,713263.

25.DefengXu*,XingXu,ZhilingZhu,AConvenientSynthesisof4-Amino-2-fluoro-N-methyl-benzamide,J.Chem.Res.,2013,10,615-616.

26.SohSF,HuangCK,LeeSO,XuD,YehS,LiJ,YongEL,GongY,ChangC.DeterminationofandrogenreceptordegradationenhancerASC-J9(®)inmouseseraandorganswithliquidchromatographytandemmassspectrometry.JPharmBiomedAnal.2014,88:117-22.

27.Zhou,SW,Xu,DF*,Wang,ZQ,Zhu,ZL,Zha,ZY,Fan,Y,Su,HK,AnEfficientandConvenientSynthesisof4,6-Dichloro-2-methyl-5-nitropyrimidine,AsianJ.Chem.,2014,26(12),3559-3561.

28.DefengXu*,ZhilingZhu,ZiqiaoWang,Aconvenientsynthesisof4,6-dimethyl-2-(methylsulfonyl)pyrimidine,J.Chem.Res.,2013,12,720-722.

29.DefengXu*,ZhilingZhu,HuiXu,ZiqiaoWang,AfacileSynthesisof4,6-dimethoxy-2-methylsulfonyl-pyrimidine,AsianJ.Chem.,2014,26(1),313-314.

30.DefengXu*,ZiqiaoWang,AFacileSynthesisof4,6-Dimethoxy-methylsulfonylpyrimidine,AsianJ.Chem.,2014,26(1),313-314.

31.MinLu,ShuwenZhou,JingGuan,XingXu,YuFan,DefengXu*,Synthesisofkeyintermediateofphosphonosulfonates(BPH-652),1-(3-iodopropyl)-3-phenoxybenzeneAsianJ.Chem.,2014,26(22),7619-7621.

32.LinTH,LeeSO,NiuY,XuD,LiangL,LiL,YehSD,FujimotoN,YehS,ChangC*.,DifferentialAndrogenDeprivationTherapieswithAnti-androgensCasodex/BicalutamideorMDV3100/EnzalutamideversusAnti-androgenReceptorASC-J9(R)LeadtoPromotionversusSuppressionofProstateCancerMetastasis.JBiolChem.2013,288(27):19359-69.

33.HsuJW,HsuI,XuD,MiyamotoH,LiangL,WuXR,ShyrCR,ChangC.Decreasedtumorigenesisandmortalityfrombladdercancerinmicelackingurothelialandrogenreceptor.AmJPathol.2013,182(5):1811-20.

34.DefengXu,Tzu-HuaLin,ShaoshunLi,JunDa,XinquinWen,JiangDing,ChawnshangChang*andShuyuanYeh*,CryptotanshinoneSuppressesAndrogenReceptor-mediatedGrowthinAndrogenDependentandCastrationResistantProstateCancerCells.CancerLetters.2012,316(1),11-22.

35.DefengXu,Tzu-HuaLin,ShaoshunLi,JingZhang,MinYin,ShuyuanYeh*,andChawnshangChang*,TheSelectiveInhibitoryEffectofaSyntheticTanshinoneDerivativeonProstateCancerCells.TheProstate,2012,72(7):803-16.(IF:3.843).

36.ShinichiYamashita,Kuo-PaoLai,Kun-LungChuang,DefengXu,HiroshiMiyamoto,TatsuoTochigi,See-TongPang,LeiLi,YoichiArai,Hsing-JienKung,ShuyuanYeh*andChawnshangChang*,ASC-J9®suppressescastration-resistantprostatecancergrowthviadegradationoffull-lengthandsplicevariantandrogenreceptors.Neoplasia,2012,14(1):74-83.

37.XiaohaiWang,Wen-JyeLin,KoujiIzumi,QiJiang,Kuo-PaoLai,DefengXu,Lei-YaFang,TianjingLu,LeiLi,ShujieXia,andChawnshangChang,IncreasedInfiltratedMacrophagesinBenignProstaticHyperplasia(BPH):ROLEOFSTROMALANDROGENRECEPTORINMACROPHAGE-INDUCEDPROSTATESTROMALCELLPROLIFERATION.J.Biol.Chem.2012,287:18376-18385.

38.QiJiang,ShuyuanYeh,XiaohaiWang,DefengXu,QiaoxiaZhang,XinquinWen,ShujieXia,ChawnshangChangetal.TargetingAndrogenReceptorLeadstoSuppressionofProstateCancerviaInductionofAutophagy.JournalofUrology,2012.188(4),1361-1368.

39.TianjingLu,Wen-JyeLin,KoujiIzumi,XiaohaiWang,DefengXu,Lei-YaFang,LeiLi,QiJiang,JieJin,ChawnshangChang,TargetingAndrogenReceptortoSuppressMacrophage-inducedEMTandBenignProstaticHyperplasia(BPH)Development.Molecularendocrinology.2012,26(10):1707-15.

40.RubingWang,RuntingYin,WenZhou,DefengXu,ShaoshunLi.Shikoninanditsderivatives:apatentreview.Expertopinionontherapeuticpatents.2012,22(9):977-97.

41.JianzhongZhang,DefengXu*,JianpinWu,Synthesisof3-(2,2,2-Trifluoroethoxy)-2pyridinesulfonamide,AsianJ.Chem.2010,22(1),826-828.

42.Li-MingZhao,Xie,Tian-Pe,He,Yu-Qin,De-FengXu,andShao-ShunLi;Synthesisandantitumoractivityof6-and2-(1-substituted-thio-4-methylpent-3-enyl)-5,8-dimethoxynaphthalene-1,4-diones,Euro.J.Med.Chem.2009,44(4),1410-1414.

43.DefengXu,Li-MingZhao,Zhi-QiangMao,andShao-ShunLi;RegioselectivePhenylAnionTransfer:ApplicationtotheTotalSynthesisof(±)-Shikonin,Org.Prep.Proced.Int.2008,41(1),93-105.

44.Li-MingZhao,DefengXu,andShao-ShunLi;Conciseformalsynthesisof(±)-Shikoninviaahighlyalpha-regioselectiveprenylationof1,4,5,8-tetramethoxynaphthalene-2-carbaldehyde,Letts.Org.Chem.2008,53(3),234-236.

45.WenZhou,DefengXu,Ai-HongZhao,andShao-ShunLi;AMildandEfficientSemi-SynthesisofLeucoacetates,JIndianChem.Soc.2008,85(1),1-3.

46.Li-MingZhao,Xie,Tian-Pe,He,Yu-Qin,De-FengXu,andShao-ShunLi;Synthesisandantitumoractivityof6-and2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthaquinones.Chin.Chem.Lett.,2008,19(10),1206-1208.

47.Ai-HongZhao,DefengXu,WenZhou,andShao-ShunLi;AConvenientSynthesisof2-Formyl-1,8:4,5-bis(methylenedioxy)naphthalene,J.Chem.Res.2007,11,647-648.

48.DefengXu,Peng-JianGuan,andShao-ShunLi;Aconvenientsynthesisof2-formyl-1,4,5,8-tetramethoxynaphthalene,J.Chem.Res.,2006,12,779–780.

49.DefengXu,Xiao-JuanGuo,Zhao-Hui,Xu,andShao-ShunLi;ANovelTotalSynthesisof(±)Shikonin，Chin.Chem.Lett.,2006,7,871-873.

专著

《天然产物全合成》，2005年化学工业出版社，参编

SELECTEDPATENTS（专利）：

总申请中国发明专利81件（国际专利1项），已授权24件

1.一种2-(2,2-二氟乙氧基)-6-三氟甲基苯磺酰氯的制备方法，ZL20181052114、

2.一种植物源杀虫剂苦皮藤素微乳剂及其制备方法，ZL201510993261.2

3.从玛咖中提取纯化玛咖酰胺单体化合物的方法，ZL2015105681935

4.一种玛咖压片及其制备方法，ZL2015101022214

5.一种纯化法可林原药的制备方法，ZL201410718642.5

6.一种嘧啶水杨酸类除草剂嘧啶肟草醚的制备方法，ZL201310228135.9

7.一种从墨旱莲中提取蟛蜞菊内酯类单体化合物的制备方法，ZL201410433292.8

8.连续化生产除草剂2,4-二氯苯氧乙酸的方法，ZL201510001030.9

9.丹参酮类化合物、制备方法及其用途，ZL201310075156.1

10.新型除草活性的嘧啶水杨酸类化合物、其制备方法及其作为除草剂的用途，ZL201380019634.5

11.一种4，6-二氯-2-甲基-5-硝基嘧啶的制备方法，ZL2013104252331

12.一种二烷基姜黄素的制备方法，ZL2013102057777

13.一种4-氨基-2-氟-N-甲基苯甲酰胺的制备方法，ZL201310222551.8

14.一种男性保健食品及其制备方法，ZL201410132486.4

15.一种药物中间体1-（3-碘丙基）-3-苯氧基苯的制备方法，ZL201310693486.7

16.一种具有祛痘功效的药物组合物及其制备方法，ZL201210439331.6

17.一种治疗痤疮的植物复方凝胶剂及其制备方法，ZL201310024533.9

18.PYRIMIDYLSALICYLATECOMPOUNDWITHNEWHERBICIDALACTIVITY,PREPARATIONMETHODTHEREFOR,ANDUSESTHEREOFASHERBICIDEWO2015081493(A1)

19.具有除草活性的氟嘧肟草醚类化合物及其制备方法，ZL2013103101669

20.除草剂双草醚的制备方法，ZL2008100371010

21.蟛蜞菊内酯的化学全合成方法，ZL200810033010X

22.紫草素二甲醚6-位侧链异构体及其衍生物和合成方法，ZL200710172161

23.紫草素二甲醚衍生物的合成方法，ZL2007100469175

24.全合成法制备消旋体紫草素，ZL2005100252431

江苏双创人才联合会副秘书长，现代农业科技专委会秘书长

中国发明家协会会员

江苏省生物技术协会特邀理事

中国农学会专业会员

中国化工学会专业会员

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