沈美华
副教授 硕导
个人简介
RESEARCHINTERESTS:
FreeRadicalChemistry,OrganometallicChemistryforsynthesisofsmallmoleculeswithimportantbiologicalactivities.(运用新颖的自由基方法或金属有机化学方法合成具有生物活性的药物小分子)
PROFESSIONALEXPERIENCE:
2012-presentAssociateProfessor
SchoolofPharmaceuticalandLifeSciences,ChangzhouUniversity,China.
2010-2012SeniorResearchScientist
ShanghaiChempartnerCO.,LTD.(上海睿智化学研究有限公司)
2008-2009PostdoctoralResearchAssociate
ChemistryDepartment,UniversityofWisconsin-Madison,USA.(威斯康星大学-麦迪逊分校)
2007-2008PostdoctoralResearchAssociate
ChemistryDepartment,UniversityofIllinoisatChicago,USA.(伊利诺依大学-芝加哥分校)
2000ChemicalEngineeringInternship
JilinChemicalIndustrialCo.,Ltd.,China.（吉林化工）
EDUCATIONALBACKGROUND:
2005Ph.DinOrganicChemitry,ShanghaiInstituteofOrganicChemistry(SIOC),ChineseAcademyofSciences(Shanghai,P.R.China)
(中国科学院上海有机化学研究所)
2000BachelorinChemistry,NortheastNormalUniversity(Changchun,P.R.China)
(东北师范大学)
近期论文
1.HaoZhou,Mei-HuaShen*，Hua-DongXu*.EvolutionoftheAza-Diels-Alderreactionof2H-azirines.SynlettReview2016,27,2171-2177.
2.Hua-DongXu*,HaoWu,ChunJiang,PengChen,Mei-HuaShen*.Chemo-,regio-,andstereoselectivehydroborationofconjugatedenynealcohol/amine:facilesynthesisofZ,Z-/Z,E-1,3-dien-1/2-ylboronicesterbearinghydroxyl/aminogroup.TetrahedronLett.2016,57(26),2915-2918.
3.Xiao-LongLu,Ya-TingLiu,Qiang-XiaWang,Mei-HuaShen*,Hua-DongXu*.Straightforwardregioselectiveconstructionof3,4-dihydro-2H-1,4-thiazinebyrhodiumcatalysed[3+3]cycloadditionofthiiranewith1-sulfonyl-1,2,3-triazole:apronouncedacidadditiveeffect.Org.Chem.Front.,2016,3(6),725-729.
4.Mei-HuaShen*,MeiHan,Hua-DongXu*.One-PotConversionofN‑Allyl-α-cyanoEsterstoα‑Allyl-α-cyanoLactamsthroughaHydrolysis/KeteneFormation/Cyclization/ClaisenRearrangementSequence.Org.Lett.2016,18(5),889-891.
5.Hua-DongXu*,HaoZhou,Ying-PengPan,Xin-TaoRen,HaoWu,MeiHan,Run-ZeHan,Mei-HuaShen*.StereoselectiveSynthesisofPolycyclesContaininganAziridineGroup:Intramolecularaza-Diels-AlderReactionsofUnactivated2H-AzirineswithUnactivatedDienes.Angew.Chem.,Int.Ed.2016,55(07),2540-2544.
6.Mei-HuaShen*,KeXu,Chu-HanSun,Hua-DongXu.Facilesynthesisofaza-spirocyclopropanyloxindolesbythereactionof3-(2-bromoethyl)-indolewith2,3-dimethylimidazole-1-sulfonylazidetriflate.Org.Biomol.Chem.,2016,14(04),1272-1276.
7.Mei-HuaShen,*Xiao-LongLu,Hua-DongXu*.Copper(II)acetatecatalysedring-openingcrosscouplingofcyclopropanolswithsulfonylazides.RSCAdv.2015,5(120),98757-98761.
8.Mei-HuaShen*,KeXu,Chu-HanSun,Hua-DongXu*.StereoselectiveConstructionofBridgedtrans-aza-Bicyclo[7/6,3/2,1]alkenylIminesthroughRingExpansionaza-CopeRearrangement.Org.Lett.2015,17(22),5598-5601.
9.Hua-DongXu*,Ying-PengPan,Xin-TaoRen,PingZhang,Mei-HuaShen*.Aone-potconstructionofacridonesbyrhodiumcatalyzedreactionofN-phenyl-2-(1-sulfonyl-1H-1,2,3-triazol-4-yl)aniline.TetrahedronLett.2015,56(48),6734-6737.
10.Mei-HuaShen*,KeXu,Chu-HanSun,Hua-DongXu*.TheReactionof2,3-Dimethylimidazole-1-sulfonylAzideTriflatewith3-SubstitutedIndoles:ReactivityandScope.Org.Lett.2015,17(15),3654-3657.
11.Mei-HuaShen*,Ying-PengPan,Zhi-HongJia,Xin-TaoRen,PingZhang,Hua-DongXu*.Anefficientapproachto1,2,3-trisubstitutedindoleviarhodiumcatalyzedcarbeneCsp3–Hbondinsertion.Org.Biomol.Chem.,2015,13(17),4851-4854.
12.Mei-HuaShen*,Ying-PengPan,Zhi-HongJia,Xin-TaoRen,PingZhang,Hua-DongXu*.Anefficientapproachto1,2,3-trisubstitutedindoleviarhodiumcatalyzedcarbeneCsp3–Hbondinsertion.Org.Biomol.Chem.,2015,13(17),4851-4854.
13.Hua-DongXu*,KeXu,HaoZhou,Zhi-HongJia,HaoWu,Xiao-LongLu,Mei-HuaShen*.Ring-Strain-DrivenCatalyticCarbeneFormation-Cyclopropanation-Aza-CopeRearrangementCascade:AFacileEntrytoFusedDihydroazepinesfrom1,3-Dienyltriazoles.Synthesis2015,47(05),641-646.
14.Hua-DongXu*,KeXu,QingZheng,Wei-JieHe,Mei-HuaShen*,Wen-HaoHu.Step-economyetherificationofacylatedalcohols.TetrahedronLett.2014,55(50),6836-6838.
15.Hua-DongXu*,KeXu,Zhi-HongJia,HaoZhou,PanJiang,Xiao-LongLu,Ying-PengPan,HaoWu,YunDing,Mei-HuaShen*,Xian-HuaPan.SubstituentEnabledDivergentSynthesisofN-Heterocycles:aMetalCarbeneApproachInvolvingIntramolecularCarbeneInterception.AsianJ.Org.Chem.2014,3(11),1154-1158.
16.Hua-DongXu*,Zhi-HongJia,KeXu,MeiHan,Sai-NanJiang,JingCao,Jia-ChengWang,Mei-HuaShen*.Copper-CatalyzedCyclization/aza-ClaisenRearrangementCascadeInitiatedbyKetenimineFormation:AnEfficientStereocontrolledSynthesisofα-AllylCyclicAmidines.Angew.Chem.,Int.Ed.2014,53(35),9284-9288.
17.Hua-DongXu*,Mao-QiangCai,Wei-JieHe,Wen-HaoHu,Mei-HuaShen*.Interceptionofbenzynewiththioethers:afacileaccesstosulfurylidesundermildconditions.RSCAdv.2014,4(15),7623-7626.