1985年7月在安徽医科大学获医学学士学位，1987年7月在安徽师范大学获文学学士学位。毕业后在安徽医科大学及安徽省医学遗传中心工作。1998年6月赴澳大利亚做访问学者，2004年4月在墨尔本大学获哲学博士学位。在澳先后从事博士后、研究官员及研究员工作。现为安徽师范大学特聘教授。◆主要研究课题

·国家自然科学基金重大研究计划项目、血管组织DC的区域免疫特性及抑炎机制、91742101、国家基金委、主持。

·安徽省对外科学技术合作项目、炎症条件下树突状细胞发育和功能的分子机制研究、1604b0602017、安徽省科技厅、主持。

·安徽省自然基金面上项目、胱抑素C调控在血管内膜损伤机制中的研究、1608085MH160、安徽省自然科学基金委员会、主持。

·澳大利亚国立卫生医学研究委员会项目基金、RegulationofCardiovascularDisease-AssociatedProteaseInhibitorCystatinCforTherapeuticApplication、1006428、主持。

·澳大利亚国立卫生医学研究委员会PeterDoherty基金、ImprovingAnti-TumorTherapybyGeneticallyModifyingCD4+Tcells、400426、主持。

·美国SusanKomen基金、GeneticModificationofMultipleImmuneSystemCellsforBreastCancerTherapy、PDF39606、主持。

免疫细胞的信号传导，炎性树突状细胞的发育和功能，免疫生化

·澳亚免疫协会会员

·安徽省细胞生物学学会常务理事

·安徽省免疫学会理事

·SunL,RautelaJ,DelconteRB,Souza-Fonseca-GuimaraesF,CarringtonEM,SchenkRL,HeroldMJ,HuntingtonND,LewAM,XuY*,ZhanY.GM-CSFQuantityHasaSelectiveEffectonGranulocyticvs.MonocyticMyeloidDevelopmentandFunction.FrontImmunol.2018Aug28;9:1922.doi:10.3389/fimmu.2018.01922.eCollection2018.

·W.Zhang,YDing,L.Sun,Q.Hong,Y.Sun,L.Han,M.Zi,Y.Xu*,Bonemarrow-derivedinflammatoryandsteadystateDCsaredifferentinbothfunctionsandsurvival.CellImmunol,331,100-109(2018).

·S.Chen,X.Li,W.Zhang,M.Zi,Y.Xu*,InflammatorycompoundlipopolysaccharidepromotesthesurvivalofGM-CSFcultureddendriticcellviaPI3kinase-dependentupregulationofBcl-x.ImmunolCellBiol,doi:10.1111/imcb.12051.[Epubaheadofprint](2018).

·ZiM,Xu,Y*.InvolvementofcystatinCinimmunityandapoptosis.ImmunolLett.196:80-90,2018

·XLi,YDing,MZi,LSun,WZhang,SChen,YXu*：CD19,frombenchtobedside.ImmunolLett,183:86-95.2017

·Xu,Y*,Ding,Y.,Li,X.,andWu,X.CystatinCisadisease-associatedproteinsubjecttomultipleregulation.ImmunolCellBiol.93(5):442-51.2015

·XuY*,LindemannP,Vega-RamosJ,ZhangJG,VilladangosJA.DevelopmentalRegulationofSynthesisandDimerizationoftheAmyloidogenicProteaseinhibitorCystatinCintheHematopoieticSystem.JBiolChem.289(14):9730-40.2014.

·XuY*,FairfaxK,LightA,HuntingtonND,TarlintonDM.CD19DifferentiallyRegulatesBCRSignallingthroughtheRecruitmentofPI3K.Autoimmunity.2014Jun23:1-8.[Epubaheadofprint].

·XuW,PanH,XuY*,andYeD.InterferonRegulatoryFactor5andAutoimmuneLupus.ExpertRevMolMed.10.1017/erm2013.7.2013.(*seniorauthor)

·LiB,YeQ,XuW,LiJ,YeDandXuY*.GM-CSFaltersdendriticcellsinautoimmunediseases.Autoimmunity.46:409.2013.

·ZhanY,Vega-RamosJ,CarringtonEM,VilladangosJA,LewAMandXuY*.Theinflammatorycytokine,GM-CSF,altersthedevelopmentaloutcomeofmurinedendriticcells.EurJImmunol.42:2889.2012.

·XuWD.PanHF,YeDQ,andXuY*.TargetingIRF4inautoimmunediseases.Autoimmun.Rev.11:918.2012.

·XuY,HuntingtonND,HarderK,NandurkarH,HibbsMLandTarlinton.Phosphatidylinositol-3kinaseactivityinBcellsisnegativelyregulatedbyLyntyrosinekinase.ImmunolCellBiol.90:903.2012

·XuY*,SchnorrerP,ProiettoA,KowalskiG,FebbraioMA,Acha-OrbeaH,DickinsRAandVilladangosJA.Interleukin-10ControlsCystatinCSynthesisandBloodConcentrationinResponsetoInflammationthroughRegulationofIRF-8Expression.J.Immunol.186:3666(2011).

·XuY*,ZhanY,LewAM,NaikSHandKershawMH.DifferentialdevelopmentofmurinedendriticcellsbyGM-CSFversusFlt3ligandhasimplicationsforinflammationandtrafficking.J.Immunol179(11):7577-84(2007).

·HuntingtonND,XuY,PuthalakathH,LightA,WillisSN,StrasserA,TarlintonDM.CD45linkstheBcellreceptorwithcellsurvivalandisrequiredforthepersistenceofgerminalcenters.Nat.Immunol.7(2):190-8.(2006).

·XuY,HarderKW,HuntingtonND,HibbsML,andTarlintonDM.Lyntyrosinekinase：accentuatingthepositiveandthenegative.Immunity.22:9-18(2005).

·HuntingtonND,XuY,NuttS,TarlintonDM.ArequirementforCD45distinguishesLy49D-mediatedcytokineandchemokineproductionfromkillinginprimaryNKcells.J.Exp.Med.201:1421-33(2005).

·XuY,DaviesJ,RamslandP,HolmdahlR,KumarN,ScealyM,RowleyM.TwomonoclonalantibodiestopreciselythesameepitopeoftypeIIcollagenselectnon-crossreactivephageclonesbyphagedisplay：implicationsforautoimmunityandmolecularmimicry.Mol.Immunol.41:411-9(2004).

·XuY,BeavittSJ,HarderKW,HibbsML,TarlintonDM.TheactivationandsubsequentregulatoryrolesofLynandCD19afterBcellreceptorligationareindependent.J.Immunol.169:6910-8(2002).