细菌致病机制、疫苗及抗菌药物研发

科研项目 一种新型肺炎链球菌矿化纳米蛋白疫苗——疫苗的构建、热稳定性及其免疫保护效应研究，国家自然科学基金（No.81571622），2016.1-2019.12，项目负责人 转录因子FabT介导的肺炎链球菌荚膜多糖合成调控的分子机制，国家自然科学基金(No.81772153)，2018.1-2021.12，项目负责人

1.WangX,YuanJ,WangH,GanN,ZhangQ,LiuB,WangJ,ShuZ,RaoL,GouX,ZhangH,YinY,ZhangX.ProgranulinDecreasesSusceptibilitytoStreptococcuspneumoniaeinInfluenzaandProtectsagainstLethalCoinfection.JImmunol.2019Sep13.pii:ji1900248.doi:10.4049/jimmunol.1900248.[Epubaheadofprint] 2.YeW,ZhangJ,ShuZ,YinY,ZhangX*,WuK*.PneumococcalLytRProteinIsRequiredfortheSurfaceAttachmentofBothCapsularPolysaccharideandTeichoicAcids:EssentialforPneumococcalVirulence.FrontMicrobiol.2018Jun13;9:1199. 3.WuJ,WuK,XuW,YuanT,WangX,ZhangJ,MinY,YinY,ZhangX*.EngineeringdetoxifiedpneumococcalpneumolysinderivativeΔA146PLYforself-biomineralizationofcalciumphosphate:Assessmentoftheirprotectiveefficacyinmurineinfectionmodels.Biomaterials.2018Feb;155:152-164. 4.SuY,LiD,XingY,WangH,WangJ,YuanJ,WangX,CuiF,YinY,ZhangX*.SubcutaneousImmunizationwithFusionProteinDnaJ-ΔA146PlywithoutAdditionalAdjuvantsInducesbothHumoralandCellularImmunityagainstPneumococcalInfectionPartiallyDependingonTLR4.FrontImmunol.2017Jun12;8:686. 5.ZhangH,KangL,YaoH,HeY,WangX,XuW,SongZ,YinY,ZhangX*.StreptococcuspneumoniaeEndopeptidaseO(PepO)ElicitsaStrongInnateImmuneResponseinMiceviaTLR2andTLR4SignalingPathways.FrontCellInfectMicrobiol.2016Feb29;6:23. 6.YaoH,ZhangH,LanK,WangH,SuY,LiD,SongZ,CuiF,YinY,ZhangX*.PurifiedStreptococcuspneumoniaEndopeptidaseO(PepO)EnhancesParticleUptakebyMacrophagesinaToll-LikeReceptor2-andmiR-155-DependentManner.InfectImmun.2017Mar23;85(4).pii:e01012-16. 7.ZhangS,WangJ,XuW,LiuY,WangW,WuK,WangZ,ZhangX.AntibacterialeffectsofTraditionalChineseMedicinemonomersagainstStreptococcuspneumoniaeviainhibitingpneumococcalhistidinekinase(VicK).FrontMicrobiol.2015May20;6:479. 8.XuX,WangH,LiuY,WangY,ZengL,WuK,WangJ,MaF,XuW,YinY,ZhangX.MucosalimmunizationwithaliveattenuatedvaccineSPY1induceshumoralandTh2-Th17-Tregcellularimmunityandprotectsagainstpneumococcalinfection.InfectImmun.2015Jan;83(1):90-100. 9.WuK,HuangJ,ZhangY,XuW,XuH,WangL,CaoJ,ZhangX*,YinY*.AnovelproteinRafXisimportantforcommoncellwallpolysaccharidebiosynthesisinStreptococcuspneumoniae:implicationsforbacterialvirulence.JBacteriol.2014Sep;196(18):3324-34. 10.LiuY,WangH,ZhangS,ZengL,XuX,WuK,WangW,YinN,SongZ,ZhangX*,YinY*.MucosalimmunizationwithrecombinantfusionproteinDnaJ-ΔA146Plyenhancescross-protectiveimmunityagainstStreptococcuspneumoniaeinfectioninmiceviaIL-17A.InfectImmun.2014Apr;82(4):1666-75.