2004- Vice-president ,CQMU 1999-2003 Vice-president of 1st. hospital of CQMU 1997-1999 Professor, Depart.of Neurology, 1st. hospital of CQMU 1995-1996 Research fellow,Neuropsychiatric department, Hamamatsu Medical University ,Japan Microbial department, Fukushima Medical University, Japan 1985-1995 Resident doctor, Depart.of Neurology, 1st. hospital of CQMU 1982-1985 Master, Neurology, CQMU 1977-1982 Bachelor, Clinical Medicine, CQMU

Depression and other Neuropsychological Research Biochemical and Molecular Biology Research Neuroimage Research Research about Infection of the Central Nervous System, Cerebrovascular Disease Research

Cipriani A, Zhou X, Del Giovane C, Hetrick SE, Qin B, Whittington C, Coghill D, Zhang Y, Hazell P, Leucht S, Cuijpers P, Pu J, Cohen D,Ravindran AV, Liu Y, Michael KD, Yang L, Liu L, Xie P. Comparative efficacy and tolerability of antidepressants for major depression in children and adolescents: a network meta-analysis. Lancet, 2016 Aug 27;388(10047):881-90. Zheng P, Zeng B, Zhou C , Liu M, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, Melgiri ND, Julio L, Wei H & Xie P. Altered gut microbiome induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Molecular Psychiatry, 2016 Jun;21(6):786-96. Wong ML, Inserra A, Lewis MD, Mastronardi CA, Leong L, Choo J, Kentish S, Xie P, Morrison M, Wesselingh SL, Rogers GB ,Licinio J. Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition . Molecular Psychiatry, 2016 Jun;21(6):797-805. Zheng P. Xie P.etc.A new pathway for the gut microbiota to modulate the brain: activation of pattern-recognition receptors by microbial products. Molecular Psychiatry （Accepted） Cheng W, Edmund T. Rolls, Qiu J, Liu W, Tang Y, Huang C, Wang X, Zhang J, Lin W, Zheng L, Pu J, Shih-Jen Tsai, Albert C. Yang, Lin C, Wang F, Xie P and Feng J. Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain.Doi:10.1093/brain/aww255 Li Q, Zhang G, Xiong X, Wang XC, Yang WS, Li KW, Wei X, Xie P.Black Hole Sign: Novel Imaging Marker That Predicts Hematoma Growth in Patients With Intracerebral Hemorrhage. Stroke, 2016 Jul;47(7):1777-81. Wang T, Wang K, Qu H, Zhou J, Li Q, Deng Z, Du X, Lv F, Ren G, Guo J, Qiu J, Xie P.Disorganized Cortical Thickness Covariance Network in Major Depressive Disorder Implicated Aberrant Hubs in Large-Scale Networks. Scientific Reports, 2016 Jun 15;6:27964 Yang Y, Chen J, Liu C, Fang L, Liu Z, Guo J, Cheng K, Zhou C, Zhan Y, Melgiri ND, Zhang L, Zhong J, Chen J, Rao C, Xie P. The Extrinsic Coagulation Pathway: a Biomarker for Suicidal Behavior in Major Depressive Disorder. Scientific Reports, 2016 Sep 8;6:32882. Zeng L, Zeng B, Wang H, Li B, Huo R, Zheng P, Zhang X, Du X, Liu M, Fang Z, Xu X, Zhou C, Chen J, Li W, Guo J, Wei H, Xie P. Microbiota Modulates Brain Development and Behavior via Protein Kinase C mediated cAMP response element-binding protein Signaling. Scientific Reports, 2016 Jul 21;6:29998. Zheng P. Xie P.etc Identification of sex-specific urinary biomarkers for major depressive disorder by combined application of NMR- and GC-MS-based metabonomics. Translational Psychiatry（Accepted） Wang W, Guo H, Zhang SX, Li J, Cheng K, Bai SJ, Yang DY, Wang HY, Liang ZH, Liao L, Sun L, Xie P. Targeted Metabolomic Pathway Analysis and Validation Revealed Glutamatergic Disorder in the Prefrontal Cortex among Chronic Social Defeat Stress Mice Model of Depression. J Proteome Res, 2016 Sep 21. Wu E, Liu X, David Dornbos Ⅲ, Josef Pfeuffer, Qian T, Qiao P, Pan Y, Dou X, Zuo Z, Liu L and Xie P. Comparison of 3D Multi-Inversion Time-Arterial Spin Labeling and Digital Subtraction Angiography in the Evaluation of Cerebral Collateral Circulation. CNS NEUROSCIENCE & THERAPEUTICS（Accepted） Zheng P, Fang Z, Xu XJ, Liu ML, Du X, Zhang X, Wang H, Zhou J, Xie P. Metabolite signature for diagnosing major depressive disorder in peripheral blood mononuclear cells. Journal of Affective Disorders, 2016 May;195:75-81. Liu X, Li J, Zheng P, Zhao X, Zhou C, Hu C, Hou X, Wang H, Xie P, Xu G. Plasma lipidomics reveals potential lipid markers of major depressive disorder. Analytical and Bioanalytical Chemistry, 2016 Sep;408(23):6497-507. Dong M, Hu Q, Shen P, Pan J, Wei Y, Liu Y, Ren Y, Liang Z, Wang H, Zhao L Xie P. Tissue plasminogen activator induces neurotoxicity after mechanical animal models of focal cerebral infarction: a systematic review and meta-analysis. Plos One（Accepted） Wu Y, Fu Y, Rao C, Li W, Liang Z, Zhou C, Shen P, Cheng P, Zeng L, Zhu D, Zhao L, Xie P. Metabolomic analysis reveals metabolic disturbances in the prefrontal cortex of the lipopolysaccharide-induced mouse model of depression. Behav Brain Res, 2016 Jul 15;308:115-27. Liu L, Zhou X, Zhang Y, Liu Y, Yang L, Pu J, Zhu D, Zhou C, Xie P. The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression. Behav Brain Res, 2016 May 15;305:148-56. Cheng K, Li J, Yang D, Yang Y, Rao C, Zhang S, Wang W, Guo H, Fang L, Zhu D, Han Y, Xie P. 2D-gel based proteomics unravels Neurogenesis and Energetic Metabolism Dysfunction of The Olfactory Bulb in CUMS rat model. Behavioural Brain Research, 2016 Oct 15;313:302-9. Wu Y, Tang J, Zhou C, Zhao L, Chen J, Zeng L, Rao C, Shi H, Liao L, Liang Z, Yang Y, Zhou J, Xie P. Quantitative proteomics analysis of the liver reveals immune regulation and lipid metabolism dysregulation in a mouse model of depression. Behavioural Brain Research, 2016 Sep,15;311:330-9 Liang Z, Bai S, Shen P, Hu Q, Wang X, Dong M, Wang W, Li J, Cheng K, Zhang S, Zou D, Han Y, Wang H, Xie P. GC-MS-Based Metabonomic Study on the Antidepressant-Like Effects of Diterpene Ginkgolides in Mouse Hippocampus. Behavioural Brain Research, 2016 Nov 1;314:116-24.