Metal ions in biology and medicine

Metal ions, such as Fe(III), Cu(II) and Mo(VI), play a key role in biological processes, such as electron transfer, oxygen transport and catalysis. In this context we are interested in the strategies used by nature to bind these essential metal ions and to tune their reactivity. Once these strategies are understood, they can be applied to other areas of co-ordination chemistry.

Interactions of a Periplasmic Binding Protein with a Tetradentate Siderophore Mimic, D. J. Raines, O. V. Moroz, K. S. Wilson, A.-K. Duhme-Klair,Angew. Chem. Int. Ed.,52, 2013, 4595. Bacteria in an Intense Competition for Iron: Key Component of the Campylobacter jejuni Iron Uptake System Scavenges Enterobactin Hydrolysis Product, D. J. Raines, O. V. Moroz, E. V. Blagova, J. P. Turkenburg, K. S. Wilson, A.-K. Duhme-Klair, Proc. Natl. Acad. Sci. U.S.A., 113, 2016, 5850. Interactions of the Periplasmic Binding Protein CeuE with Fe(III) n-LICAM4- Siderophore Analogues of Varied Linker Length, E. J. Wilde, A. Hughes, E. V. Blagova, O. V. Moroz, R. P. Thomas, J. P. Turkenburg, D. J. Raines, A.-K. Duhme-Klair, K. S. Wilson, Sci. Rep.,7, 2017, 45941. Staphyloferrin A as Siderophore-component in Fluoroquinolone-based Trojan Horse Antibiotics, S. J. Milner, A. Seve, A. M. Snelling, G. H. Thomas, K. Kerr, A. Routledge, A.-K. Duhme-Klair, Org. Biomol. Chem.,11, 2013, 3461. Probing Linker Design in Citric Acid-Ciprofloxacin Conjugates, S. J. Milner, A. M. Snelling, K. G. Kerr, A. Abd-El-Aziz, G. H. Thomas, R. E. Hubbard, A. Routledge, A.-K. Duhme-Klair,Bioorg. Med. Chem.,22, 2014, 4499. Electronic Fine Tuning of Oxygen Atom Transfer Reactivity of cis-Dioxomolybdenum(VI) Complexes with Thiosemicarbazone Ligands, A. B. Ducrot, B. Scattergood, B. A. Coulson, R. N. Perutz, A.-K. Duhme-Klair, Eur. J. Inorg. Chem.,2015, 3562. Light-induced Activation of a Molybdenum Oxotransferase Model within a Ru(II)-Mo(VI) Dyad, A. B. Ducrot, B. A. Coulson, R. N. Perutz, A.-K. Duhme-Klair, Inorg. Chem., 55, 2016, 12583.