Ph.D., University of California, Irvine, 1981

Physical Chemistry Chemical Biology Center for Structural Biology Biochemistry

DNA damage is believed to represent the initiating step in chemical carcinogenesis. Our laboratory seeks to understand how specific DNA adducts perturb DNA structure and how these structural interfere with the biological processing of DNA. One goal is to understand the basis whereby chemical modification of DNA triggers specific mutations. Some mutations, especially those occurring in proto-oncogene sequences or tumor suppressor gene sequences, play crucial roles in the process of chemical carcinogenesis.

Kowal, E.A., Katapati, S., Turo, M., Tretyakova, N., Stone, M. P. Major Groove Orientation of the (2S)-N6-(2-hydroxy-3-buten-1-yl)-2'-Deoxyadenosine DNA Adduct Induced by 3,4-epoxy-1-Butene. Chemical Research in Toxicology. 2014, (27): 1675-1686. Kowal, E.A., Seneviratne, U., Wickramaratne, S., Doherty, K., Cao, X., Tretyakova, N.Y., Stone, M. P. Structures of Exocyclic S,S- and R,R N6,N6-(2,3-Dihydroxy-1,4-butadiyl)-2'-deoxyadenosine Adducts Induced by 1,2,3,4-Diepoxybutane. Chemical Research in Toxicology. 2014, (27): 805-817. Stavros, K.M., Hawkins, E.K., Rizzo, C.J., Stone, M. P. Base-Displaced Intercalation of the N2-2-Amino-3-methylimidazo[4,5-f]quinoline-dG Adduct in the NarI Recognition Sequence. Nucleic Acids Research. 2014, (42): 3450-3463. Kowal, E. A., Lad, R. R., Pallan, P. S., Dhummakupt, E., Wawrzak, Z., Egli, M., Sturla, S. J., Stone, M. P. Recognition of O-6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction. Nucleic Acids Research. 2013, 41 (15): 7566-7576. Shanmugam, G., Minko, I. G., Banerjee, S., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Lloyd, R. S., Egli, M., Stone, M. P. Ring-Opening of the gamma-OH-PdG Adduct Promotes Error-Free Bypass by the Sulfolobus solfataricus DNA Polymerase Dpo4. Chemical Research in Toxicology. 2013, 26 (9): 1348-1360. Szulik, M. W., Voehler, M. W., Ganguly, M., Gold, B., Stone, M. P. Site-Specific Stabilization of DNA by a Tethered Major Groove Amine, 7-Aminomethyl-7-deaza-2 '-deoxyguanosine. Biochemistry. 2013, 52 (43): 7659-7668. Ganguly, M., Szulik, M. W., Donahue, P. S., Clancy, K., Stone, M. P. Thermodynamic Signature of DNA Damage: Characterization of DNA with a 5-Hydroxy-2 '-deoxycytidine center dot 2 '-Deoxyguanosine Base Pair. Biochemistry. 2012, 51 (9): 2018-2027. Huang, H., Das, R. S., Basu, A. K., Stone, M. P. Structures of (5 ' S)-8,5 '-Cyclo-2 '-deoxyguanosine Mismatched with dA or dT. Chemical Research in Toxicology. 2012, 25 (2): 478-490. Banerjee, S., Christov, P. P., Kozekova, A., Rizzo, C. J., Egli, M., Stone, M. P. Replication Bypass of the trans-4-Hydroxynonenal-Derived (6S,8R,11S)-1,N-2-Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IV. Chemical Research in Toxicology. 2012, 25 (2): 422-435. Ganguly, M., Szulik, M. W., Donahue, P. S., Clancy, K., Stone, M. P., Gold, B. Thermodynamic Signature of DNA Damage: Characterization of DNA with a 5-Hydroxy-2 '-deoxycytidine center dot 2 '-Deoxyguanosine Base Pair. Pharmazeutische Industrie. 2012, 74 (2): 2018-2027. Stone, M. P., Huang, H., Brown, K. L., Shanmugam, G. Chemistry and Structural Biology of DNA Damage and Biological Consequences. Chemistry & BioDiversity. 2011, 8 (9): 1571-1615. Kowal, E. A., Ganguly, M., Pallan, P. S., Marky, L. A., Gold, B., Egli, M., Stone, M. P. Altering the Electrostatic Potential in the Major Groove: Thermodynamic and Structural Characterization of 7-Deaza-2 '-deoxyadenosine:dT Base Pairing in DNA. Journal of Physical Chemistry B. 2011, 115 (47): 13925-13934.

Singh, S. K., Szulik, M. W., Ganguly, M., Khutsishvili, I., Stone, M. P., Marky, L. A., Gold, B. Characterization of DNA with an 8-oxoguanine modification. Nucleic Acids Research. 2011, 39 (15): 6789-6801.