Education Undergraduate Fudan University - China (2001), Chemistry Graduate School University of California-Berkeley (2006), Chemistry Honors & Awards CPRIT Scholar in Cancer Research Cancer Prevention Research Institute of Texas (2011) University of Texas STARS award University of Texas System (2011) Virginia Murchison Linthicum Scholar in Medical Research UT Southwestern Medical Center (2011) Tuberous Sclerosis Alliance Postdoctoral Fellowship Tuberous Sclerosis Alliance (2008) Chun-Tsung Scholar Chun-Tsung Endowment (1999)

Research Interest Mass Spectrometry Proteomics Signal Transduction/Cancer Biology

Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome. Zhang Y, Wang J, Ding M, Yu Y Nat. Methods 2013 Aug Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J Science 2011 Jun 332 6035 1322-6 Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Kubota K, Anjum R, Yu Y, Kunz RC, Andersen JN, Kraus M, Keilhack H, Nagashima K, Krauss S, Paweletz C, Hendrickson RC, Feldman AS, Wu CL, Rush J, Villén J, Gygi SP Nat. Biotechnol. 2009 Oct 27 10 933-40 A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry. Yu Y, Anjum R, Kubota K, Rush J, Villen J, Gygi SP Proc. Natl. Acad. Sci. U.S.A. 2009 Jul 106 28 11606-11 Determination of the sites of tyrosine O-sulfation in peptides and proteins. Yu Y, Hoffhines AJ, Moore KL, Leary JA Nat. Methods 2007 Jul 4 7 583-8 Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J Genes Dev. 2015 Jan 29 2 157-70 Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G Proc. Natl. Acad. Sci. U.S.A. 2014 Apr Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1. Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F Cell Metab. 2014 Apr Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W Nat. Cell Biol. 2013 Oct