Education Undergraduate Trinity University (1990), Biology Graduate School University of Virginia Main Campus (1996), Microbiology Honors & Awards Young Investigator Award American Cancer Society/Simmons Cancer Center, UTSW (2002) Individual National Research Service Award National Cancer Institute (1998) Postdoctoral Fellowship Leukemia Research Foundation (1997)

Research Interest pharmacokinetics small molecule therapeutics toxicology

A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma Sivanand S, Peña-Llopis S, Zhao H, Kucejova B, Spence P, Pavia-Jimenez A, Yamasaki T, McBride DJ, Gillen J, Wolff NC, Morlock L, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross MT, Bentley DR, Kabbani W, Xie XJ, Kapur P, Williams NS, Brugarolas J. Sci. Transl. Med. 2012 4 137 137ra75 An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA. Cancer Res. 2012 72 12 3038-47 Development of proneurogenic, neuroprotective small molecules. MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM J. Am. Chem. Soc. 2011 Feb 133 5 1428-37 Discovery of a proneurogenic, neuroprotective chemical. Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL Cell 2010 Jul 142 1 39-51 Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C Bioorg. Med. Chem. Lett. 2009 Jul 19 14 3825-7 Targeting QseC signaling and virulence for antibiotic development Rasko, DA, CG Moreira, DR Li, NC Reading, JM Ritchie, MK Waldor, N Williams, R Taussig, S Wei, M Roth, DT Hughes, JF Huntley, MW Fina, JR Falck, and V Sperandio Science August 2008 321 1078-1080 Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA. Proc. Natl. Acad. Sci. 2012 109 42 17010-5 Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA. Proc. Natl. Acad. Sci. 2012 109 42 17016-21 Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species. Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA, Williams NS, Terada LS, Nwariaku FE Am. J. Physiol., Cell Physiol. 2011 Sep 301 3 C695-704 Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM Nat. Chem. Biol. 2011 7 10 Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L Nat. Chem. Biol. 2009 Feb 5 2 100-7 Phase I dose escalation study with inrinotecan, capecitabine, epirubicin, and GCSF support for patients with solid malignancies Becerra, C.R., U.N. Verma, H.T. Tran, D. Tavana, N.S. Williams, E.P. Frenkel American Journal of Clinical Oncology June 2008 31 219-225 Pillars article: Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992. 255: 1261-1263. Hunt DF, Henderson RA, Shabanowitz J, Sakaguchi K, Michel H, Sevilir N, Cox AL, Appella E, Engelhard VH J. Immunol. 2007 Sep 179 5 Synthesis of psymberin analogs: probing a functional correlation with the pederin/mycalamide family of natural products Xin, J., Williams, N., De Brabander, J Organic Letters 2007 9 227-230 Therapeutic anti-cancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity Williams, N.S., Burgett, A.W.G., Atkins, A.S., Wang, X., Harran, P.G., and McKnight, S.L. Proc. Natl. Acad. Sci. USA 2007 104 2074-2079 Selective identification of secreted and transmembrane breast cancer markers using Escherichia coli ampicillin secretion trap. Ferguson DA, Muenster MR, Zang Q, Spencer JA, Schageman JJ, Lian Y, Garner HR, Gaynor RB, Huff JW, Pertsemlidis A, Ashfaq R, Schorge J, Becerra C, Williams NS, Graff JM Cancer Res. 2005 Sep 65 18 8209-17 Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference. Zhou A, Scoggin S, Gaynor RB, Williams NS Oncogene 2003 Apr 22 13 2054-64 Identification and validation of genes involved in the pathogenesis of colorectal cancer utilizing cDNA microarrays and RNA interference. Williams, N.S., R.B. Gaynor, S. Scoggin, U. Verma, T. Gokaslan, C. Williams, N.S., R.B. Gaynor, S. Scoggin, U. Verma, T. Gokaslan, C. Simmang, J. Fleming, D. Tavana, E. Frenkel, and C. Becerra. Clinical Cancer Research 2003 9 931-946 ARROGANT: an application to manipulate large gene collections. Kulkarni AV, Williams NS, Lian Y, Wren JD, Mittelman D, Pertsemlidis A, Garner HR Bioinformatics 2002 Nov 18 11 1410-7 Clonal analysis of NK cell development from bone marrow progenitors in vitro: orderly acquisition of receptor gene expression.

Williams NS, Kubota A, Bennett M, Kumar V, Takei F Eur. J. Immunol. 2000 Jul 30 7 2074-82