Education Graduate School Oregon State University (1957) Graduate School University of California-Berkeley (1962) Honors & Awards William S. Middleton Award (1984)

Research Interest Glucose signaling pathway and its signaling mechanism in lipogenesis. Long term regulation which includes transcriptional controls by hormones, nutrients and stress factors. Regulation of carbohydrate metabolism and lipogenesis in various mammalian tissues. Short term regulation such as allosteric controls of key enzymes in glucose metabolism and fat synthesis.

Carbohydrate-response element-binding protein deletion alters substrate utilization producing and energy-deficient liver Burgess, SC, Iizuka, K, Jeoung,NH, Harris, RA, Kahsiwaya, Y, Veech, RL, Kitazume, T., and Uyeda, K J. Biol. Chem. January 2008 283 1670-1678 A Glucose-Responsive Transcription Factor that regulates Carbohydrate Metabolism in the liver. Yamashita, H.,Takenoshita, M., Sakurai, M., Bruick, R.K., Henzel, W.J., Shillinglaw, W., Arnot, D., and Uyeda, K. Proc Natl. Acad. Sci. 2001 98 9116-9121 Glucose and cAMP Regulate L-type Pyruvate Kinase Gene by Phosphorylation/Dephosphorylation of the Carbohydrate Response Element Binding Protein. Kawaguchi, T., Takenoshita, M., Kabashima, T., and Uyeda, K. Proc. Natl..Acad. Sci. 2001 98 13710 13715 Crystallization and Preliminary X-ray Analysis of Fructose 6-phosphate,2-kinase:Fructose 2,6-bisphosphatase. Istvan, E.S., Hasemann, C.A., Kurumbail, R.G., Uyeda, K., and Deisenhofer, J. Protein Sci. 1995 4 2439-2441 Catalyzing Dephosphorylation of Fructose 6-phosphate,2-kinase:Fructose 2,6-bisphosphatase Nishimura, M. and Uyeda, K. J. Biol. Chem. 1995 270 9116-9121 Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP) Sakiyamam H, Wynn, RM, Lee, WR, Fukasawa, M, Mizuguchi, H, Gardner, KH, Repa, JJ, and Uyeda,K J Biol. Chem. September 2008 283 24899-24908 Carbohydrate-response element-binding protein deletion alters substrrate utilization producing an energy-deficient liver Burgess, SC, Iizuka, K., Jeoung, NH, Harris, RA, Kashiwaya, Y, Veech, RL, Kitazume, T, and Uyeda, K., J. Biol. Chem 2008 283 1670-1678 Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Uyeda, K., and Repa, J.J. Cell Metabolism 2006 4 107-110 Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Iizuka, K., Miller, B., and Uyeda, K. Am. J. of Physiol. Endcrinol. Metab. 2006 291 E358-E364 Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.

Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. Proc. Natl. Acad. Sci. USA May 2003 100(10) 5578-80