Education Undergraduate Washington State University (1983), Chemistry Graduate School University of Wisconsin Centers (1990), Chemistry Honors & Awards American Heart Association Postdoctoral Fellowship (1991-1993) National Merit Scholar Washington State University (1979-1983)

Research Interest Molecular mechanisms of neurotransmitter release, as studied by x-ray crystallography. Structure and function of lipoproteins from the bacterium T. pallidum, the causative agent of syphilis. Structure and mechanism of enzymes and metalloenzymes. Structure of proteins involved in cell signaling and division.

The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors. Li W, Ma C, Guan R, Xu Y, Tomchick DR, Rizo J Structure 2011 Oct 19 10 1443-55 Mechanism of actin filament nucleation by the bacterial effector VopL. Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK Nat. Struct. Mol. Biol. 2011 Sep 18 9 The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM Nature 2011 Jan 469 7328 107-11 Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK Cell 2010 Jan 140 2 246-56 Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. Yang M, Li B, Liu CJ, Tomchick DR, Machius M, Rizo J, Yu H, Luo X PLoS Biol. 2008 Mar 6 3 e50 p31comet blocks Mad2 activation through structural mimicry. Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H, Luo X Cell 2007 Nov 131 4 744-55 Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H Nat. Struct. Mol. Biol. 2007 Jun 14 6 535-9 Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin. Deka RK, Brautigam CA, Tomson FL, Lumpkins SB, Tomchick DR, Machius M, Norgard MV J. Biol. Chem. 2007 Feb 282 8 5944-58 Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H Mol. Cell 2006 Aug 23 3 377-87 Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. Lu J, Machius M, Dulubova I, Dai H, Südhof TC, Tomchick DR, Rizo J PLoS Biol. 2006 Jul 4 7 e192 Structural basis of Rho GTPase-mediated activation of the formin mDia1. Otomo T, Otomo C, Tomchick DR, Machius M, Rosen MK Mol. Cell 2005 Apr 18 3 273-81 Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Otomo T, Tomchick DR, Otomo C, Panchal SC, Machius M, Rosen MK Nature 2005 Feb 433 7025 488-94 Three-dimensional structure of the complexin/SNARE complex. Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J Neuron 2002 Jan 33 3 397-409 A protein catalytic framework with an N-terminal nucleophile is capable of self-activation. Brannigan JA, Dodson G, Duggleby HJ, Moody PC, Smith JL, Tomchick DR, Murzin AG Nature 1995 Nov 378 6555 416-9 Three-dimensional structure of myosin subfragment-1: a molecular motor. Rayment I, Rypniewski WR, Schmidt-Bäse K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM Science 1993 Jul 261 5117 50-8 Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2. Xu J, Bacaj T, Zhou A, Tomchick DR, Südhof TC, Rizo J Structure 2014 Feb 22 2 269-80 The Bacterial Effector VopL Organizes Actin into Filament-like Structures. Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK Cell 2013 Oct 155 2 423-34 Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5. Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D, Luo X Structure 2013 Aug Structure of the human cohesin inhibitor Wapl. Ouyang Z, Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H Proc. Natl. Acad. Sci. U.S.A. 2013 Jun

The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis. Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV J. Biol. Chem. 2013 Feb