Biography Uttam Tambar is an organic chemist with an interest in biomedical research. He received his AB degree from Harvard University in 2000, and his PhD from the California Institute of Technology in 2006. He was an NIH Postdoctoral Fellow at Columbia University (2006-2009). He began his independent research career in 2009 at UT Southwestern. Dr. Tambar is interested in developing new strategies and concepts in synthetic chemistry to address challenging problems in biomedical research. In addition to making fundamental advances in chemistry, he will take advantage of the unique opportunities for collaborative research at UT Southwestern. Laboratory Website: http://www4.utsouthwestern.edu/tambarlab Education Graduate School Harvard University (2000), Chemistry Graduate School California Institute of Technology (2006), Chemistry Honors & Awards Sloan Foundation Research Fellowship (2013-2014) W. W. Caruth, Jr. Scholar in Biomedical Research (2009) NIH Ruth L. Kirschstein NRSA Postdoctoral Fellow (2006) National Defense Science and Engineering Graduate Fellow (2001) John Harvard Scholar (1999)

he Tambar Group is developing new strategies and concepts in synthetic chemistry to address some of the most challenging problems in our field. Our chemical discoveries will be applied to the synthesis of complex biologically active natural products and their unnatural analogs. In addition to making fundamental advances in the areas of total synthesis and reaction discovery, we are taking advantage of the unique opportunities in medicinal chemistry at UT Southwestern Medical Center. Research Interest Development of new tandem chemical reactions Discovery of small molecule drugs Synthesis of complex biologically active natural products

Regioselective and diastereoselective aminoarylation of 1,3-dienes. Hongli Bao, Liela Bayeh, and Uttam K. Tambar. Chem. Sci. 2014, 5, 4863–4867. aminoarylation Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase. Shih-Chia Tso, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Xiangbing, Qi, Kristen J. Skvorak, Kenneth Dorko, Amy L. Wallace, Lorraine K. Morlock, Brendan H. Lee, Susan M. Hutson, Stephen C. Strom, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, and David T. Chuang. J. Biol. Chem. 2014, 289, 20583–20593.. PS10 Allylic Functionalization of Unactivated Olefins with Grignard Reagents. Hongli Bao, Liela Bayeh, and Uttam K. Tambar. Angew. Chem. Int. Ed. 2014, 53, 1664–1668. (German Edition) Allylic Alkylation Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock, Kyle R. Owens, Philipp E. Scherer, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn and David T. Chuang. J. Biol. Chem. 2014, 289, 4432-4443. PS10 as a PDK Inhibtor Brønsted Acid Catalyzed Enantioselective Indole Aza-Claisen Rear-rangement Mediated by an Arene CH-O Interaction. Pradip Maity, Ryan P. Pemberton, Dean J. Tantillo, and Uttam K. Tambar. J. Am. Chem. Soc. 2013, 135, 16380–16383. (This article was featured in Synfacts) Indole_aza_Claisen Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ­ent-Sitagliptin. Hongli Bao, Liela Bayeh, Uttam K. Tambar. Synlett 2013, 24, 2459-2463. (This article was featured as the SYNFACT of the month) Sitagliptin Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement. Arash Soheili and Uttam K. Tambar. Org. Lett. 2013, 15, 5138–5141. (This article was featured in Organic Highlights) Amathaspiramide Stereoselective Synthesis of Functionalized Cyclic Amino Acid Derivatives via a [2,3]-Stevens Rearrangement and Ring-Closing Metathesis. Aaron Nash, Arash Soheili, and Uttam K. Tambar. Org. Lett. 2013, 15, 4770–4773. Cylic Amino Acid Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase. Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K. Tambar, R. Max Wynna, and David T. Chuang. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 9728–9733. (This article was featured in SciBX) CPP_TOC Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor. Jamie L. Rogers, Liela Bayeh, Thomas H. Scheuermann, Jamie Longgood, Chuck Caldwell, Jason Key, Jacinth Naidoo, Lisa Melito, Cameron Shokri, Doug E. Frantz, Richard K. Bruick, Kevin H. Gardner, John B. MacMillan, and Uttam K. Tambar. J. Med. Chem. 2013, 56, 1739–1747. HIF- Chem Allosteric Inhibition of Hypoxia Inducible Factor 2 with Small Molecules. Thomas H. Scheuermann, Qiming Li, He-Wen Ma, Jason Key, Lei Zhang, Rui Chen, Joseph A. Garcia, Jacinth Naidoo, Jamie Longgood, Douglas E. Frantz, Uttam K. Tambar, Kevin H. Gardner, and Richard K. Bruick. Nat. Chem. Biol. 2013, 9, 271–276. HIF- Chem Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement. Hongli Bao and Uttam K. Tambar. J. Am. Chem. Soc. 2012, 134, 18495–18498. (This article was featured in the Editors’ Choice section of Science, Synfacts, Synform, and Organic Highlights) Our chemistry is highlighted on the Sigma-Aldrich Website. [2,3] Stevens Rearrangement Tandem Catalytic Allylic Amination and [2,3]-Stevens Rearrangement of Tertiary Amines. Arash Soheili and Uttam K. Tambar. J. Am. Chem. Soc. 2011, 133, 12956-12959. (This article was featured in Synfacts) [2,3] Stevens Rearrangement SYNPACTS: Stereoselective [2,3]-Rearrangements of Amine N-Oxides. Hongli Bao, Xiangbing Qi, and Uttam K. Tambar. Synlett 2011, 1789-1792. scheme-12 Total Synthesis of (±)-Trigonoliimine C via Oxidative Rearrangement of an Unsymmetrical Bis-Tryptamine. Xiangbing Qi, Hongli Bao, and Uttam K. Tambar. J. Am. Chem. Soc. 2011, 133, 10050-10053. Trigonoliimine C Catalytic Enantioselective [2,3]-Rearrangements of Amine N-Oxides. Hongli Bao, Xiangbing Qi, and Uttam K. Tambar. J. Am. Chem. Soc. 2011, 133, 1206-1208. (This article was featured in Synfacts) scheme-10 Graduate and Postdoctoral Publications Enantioselective (Formal) Aza-Diels-Alder Reactions with Non-Danishefsky-Type Dienes. Uttam K. Tambar , Sharon K. Lee, and James L. Leighton. J. Am. Chem. Soc. 2010, 132, 10248-10250. (This article was featured in Synfacts) scheme-9 Highly enantioselective formal aza-Diels–Alder reactions with acylhydrazones and Danishefsky’s diene promoted by a silicon Lewis acid. Sharon K. Lee, Uttam K. Tambar, Nicholas R. Perl, and James L. Leighton. Tetrahedron 2010, 66, 4769-4774. (This article was featured in Synfacts) scheme-8 The Direct Acyl-Alkylation of Arynes. Preparation of Methyl 2-(2-Acetylphenyl)Acetate. David C. Ebner, Uttam K. Tambar, Brian M. Stoltz. Org. Synth. 2009, 86, 161-171. scheme-7 Pd-Catalyzed Enantioselective Aerobic Oxidation of Secondary Alcohols: Applications to the Total Synthesis of Alkaloids. Shyam Krishnan, Jeffrey T. Bagdanoff, David C. Ebner, Yeeman K. Ramtohul, Uttam K. Tambar, Brian M. Stoltz. J. Am. Chem. Soc. 2008, 130, 13745-13754.