Biography Download Curriculum Vitae Carole Mendelson received a B.S. in Biology from the City College of New York and a Ph.D. in Zoology from Rutgers University, New Brunswick, N.J. She spent five years as a postdoctoral and then Staff Fellow at the National Institutes of Health in Bethesda, Maryland. She joined the faculty of UT Southwestern in 1978. Research in the Mendelson laboratory is focused on reproductive and perinatal biology and includes: (1) genetic and epigenetic mechanisms in the developmental, hormonal and tissue-specific regulation of the gene encoding SP-A, the major protein of pulmonary surfactant; (2) transcriptional regulation of aromatase (CYP19) gene expression in estrogen-producing tissues and in pathologic states, including endometriosis, cancer and preeclampsia; (3) regulatory mechanisms involved in maintenance of uterine quiescence during pregnancy and activation of contractile genes leading to term and pre-term labor. Dr. Mendelson’s research is funded by the National Institutes of Health and March of Dimes Foundation. She held an NIH MERIT Award from 1998 – 2008. Dr. Mendelson served as a member of the Board of Scientific Counselors for the National Heart, Lung and Blood Institute, NIH, and currently chairs the Reproductive Scientist Development Program Selection Committee and is a member of the Basil O’Connor Starter Scholar Research Award Advisory Committee. She is active within The Endocrine Society (TES), in which she has chaired a number of committees and served as a member of Council and as Vice President for Basic Scientists from 2008 – 2011. She also has been active in several committees that support the career advancement of women in science and medicine. She was president of Women in Endocrinology of TES. Within UT Southwestern, she co-chairs the Women in Science and Medicine Advisory Committee and chairs the Committee on the Advancement of Women. Education Undergraduate City College of New York (1964), Biology Graduate School Rutgers University New Brunswick (1970), Zoology Honors & Awards SGI-Pardi President's Distinguished Scientist Award, Society for Reproductive Investigation Award for Scientific Excellence (2014) Mentor Award Women in Endocrinology (2010) Vice-President, Basic Science The Endocrine Society (2008-2011) Alpha Omega Alpha Honor Society (2002) Roy O. Greep Award The Endocrine Society (2001) NIH MERIT Award Regulation of SP-A Expression in Fetal Lung (1998-2008)

Research Interest Mechanisms in the initiation of parturition Molecular Mechanisms in the developmental, hormonal and tissue-specific regulation of surfactant protein gene expression in fetal lung tissue Molecular mechanisms in the regulation of aromatase in estrogen-producing cells

MicroRNAs-mediators of myometrial contractility during pregnancy and labour. Renthal NE, Williams KC, Mendelson CR Nat Rev Endocrinol 2013 May MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor. Williams KC, Renthal NE, Condon JC, Gerard RD, Mendelson CR Proc. Natl. Acad. Sci. U.S.A. 2012 May 109 19 7529-34 Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Benlhabib H, Mendelson CR Mol. Cell. Biol. 2011 May 31 10 1949-58 miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Renthal NE, Chen CC, Williams KC, Gerard RD, Prange-Kiel J, Mendelson CR Proc. Natl. Acad. Sci. U.S.A. 2010 Nov 107 48 20828-33 Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition. Condon JC, Jeyasuria P, Faust JM, Mendelson CR Proc. Natl. Acad. Sci. U.S.A. 2004 Apr 101 14 4978-83 Regulation of the synthesis of the major surfactant apoprotein in fetal rabbit lung tissue Mendelson CR, Chen C, Boggaram V, Zacharias C, Snyder JM J Biol Chem 1986 261 9938-9943 Isolation and characterization of a complementary DNA specific for human aromatase cytochrome P-450 mRNA Evans CT, Ledesma DB, Schulz TZ, Simpson ER, Mendelson CR Proc Natl Acad Sci USA 1986 83 6387-6391 Estrogen-related Receptor ? (ERR?) Serves a Role in Blood Pressure Homeostasis during Pregnancy. Luo Y, Kumar P, Chen CC, Latham J, Wang L, Tudela C, Alexander JM, Shelton JM, McKown L, Mendelson CR Mol. Endocrinol. 2014 Apr me20141003 Estrogen-Related Receptor ? (ERR?) Regulates Oxygen-Dependent Expression of Voltage-gated Potassium (K+) Channels and Tissue Kallikrein during Human Trophoblast Differentiation. Luo Y, Kumar P, Mendelson CR Mol. Endocrinol. 2013 Apr The c-Myc Regulated microRNA (miR)-17~92 and miR-106a~363 Clusters Target CYP19A1 and hGCM1 to Inhibit Human Trophoblast Differentiation. Kumar P, Luo Y, Tudela C, Alexander JM, Mendelson CR Mol. Cell. Biol. 2013 Feb Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes. Montalbano AP, Hawgood S, Mendelson CR Endocrinology 2013 Jan 154 1 483-98 The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor. Williams KC, Renthal NE, Gerard RD, Mendelson CR Mol. Endocrinol. 2012 Nov 26 11 1857-67 Progesterone Receptor Inhibits Proliferation of Human Breast Cancer Cells via Induction of MAPK Phosphatase 1 (MKP-1/DUSP1). Chen CC, Hardy DB, Mendelson CR J. Biol. Chem. 2011 Dec 286 50 43091-102 Estrogen-Related Receptor {gamma} (ERR{gamma}) Mediates Oxygen-Dependent Induction of Aromatase (CYP19) Gene Expression during Human Trophoblast Differentiation. Kumar P, Mendelson CR Molecular endocrinology (Baltimore, Md.) 2011 Jul 1513-26 Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. Maitra M, Wang Y, Gerard RD, Mendelson CR, Garcia CK J. Biol. Chem. 2010 Jul 285 29 22103-13 Minireview: fetal-maternal hormonal signaling in pregnancy and labor. Mendelson CR Mol. Endocrinol. 2009 Jul 23 7 947-54 cAMP enhances estrogen-related receptor alpha (ERRalpha) transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid receptor coactivator 2 (SRC-2). Liu D, Benlhabib H, Mendelson CR Mol. Endocrinol. 2009 Jun 23 6 772-83 cAMP enhances estrogen-related receptor alpha (ERRalpha) transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid receptor coactivator 2 (SRC-2) Liu D, Benlhabib H, Mendelson CR Mol Endocrinol 2009 23 772-783 Estrogen receptor alpha (ERalpha) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta Kumar P, Kamat A, Mendelson CR Mol Endocrinol 2009 23 784-93 Androstenedione up-regulation of endometrial aromatase expression via local conversion to estrogen: potential relevance to the pathogenesis of endometriosis.

Bukulmez O, Hardy DB, Carr BR, Auchus RJ, Toloubeydokhti T, Word RA, Mendelson CR J. Clin. Endocrinol. Metab. 2008 Sep 93 9 3471-7