Undergraduate Kalamazoo College , Biology Graduate School Wayne State University (1981) Jackson Laboratory, Bar Harbor, ME Scientific Advisory Bard of Induced Mutant Resource (1996) State Capital of Wiesbaden, Germany Carol-Nachman Prize in Rheumatology (1992) USDA Unit Award for Distinguished Service Application of Gene Transfer to Farm Animals (1989) University of Pennsylvania School of Veterinary Medicine NIH Postdoctoral Fellowship (1983)

In vivo models of cancer Oncogene and growth factor collaboration in cancer Regulation of growth and proliferation Regulation of liver growth

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Hammer, R.E., Maika, S.D., Richardson, J.A., Tang, J.P., and Taurog, J.D. Cell 1990 63 1099-1112 Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice. Hofmann, S.L., Russell, D.W., Brown, M.S., Goldstein, J.L., and Hammer, R.E. Science 1988 239 1277-1281 Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Hammer, R.E., Brinster, R.L., Rosenfeld, M.G., Evans, R.M., and Mayo, K.E. Nature 1985 315 413-416 Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene. Hammer, R.E., Palmiter, R.D., and Brinster, R.L. Nature 1984 311 65-67 Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.E., Rosenfeld, M.G., Birnberg, N.C., and Evans, R.M. Nature 1982 300 611-615 Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis Engelking, L.J., Kuriyama, H, Hammer, R.E., Horton, J. D., Brown, M.S.,Goldstein, J. L. and Liang, G J. Clinical Investigation Spring 2004 113 1168-75 Overexpression of sterol regulatory element-binding protein 1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver Horton, J. D., Shiomorura, I., Ikemoto, S.,Bashmakov, Y., and Hammer, R.E. J. Biological Chemistry 2003 278 36652-60 Induction of hepatocyte proliferation and death by modulation of T-Antigen expression. Comerford, S.A., Clouthier, D.E., Hinnant, E., and Hammer, R.E. Oncogene 2003 22 2515-2530 Regualtion of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes Beale, E.G., Forest, C., and Hammer, R.E. Biochimie 2003 85 1207-11 Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.

Clouthier, D.E., Comerford, S.A., and Hammer, R.E. J. Clin. Invest. 1997 100 2697-2713