Biography Download Curriculum Vitae Dr. David R. Corey was born in Cambridge. Mass., August 13, 1963. He received his BA degree in Chemistry from Harvard University in 1985, and his PhD in Chemistry from the University of California at Berkeley in 1990. He completed postdoctoral training with Dr. Charles Craik in the Department of Pharmaceutical Chemistry at the University of California at San Francisco (1990-1992). In 1992 Dr. Corey joined the faculty of the Department of Pharmacology at the University of Texas Southwestern Medical Center at Dallas as an Assistant Professor. In 1996 Dr. Corey received a secondary appointment to the Department of Biochemistry, and in 1998 he was promoted to Associate Professor and to Full Professor in 2003. Education Undergraduate Harvard University , Chemistry Graduate School University of California-Berkeley (1990) Honors & Awards Excellence Postdoctoral Mentoring Award (2010) McKnight Neuroscience Award (2009) Welch Lectueship (2003) CaP Cure Research Award (1996) Damon Runyon Postdoctoral Fellowship (1990)

Research Interest antigene oligonucleotides antisense oligonucleotides Nucleic acids RNAi Telomerase

Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. (2005) "Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids" Nature Chemical Biology 1, 210-215. Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D., and Corey D. R. (2005) "Inhibiting gene expression at transcription start sites in chromosomal DNA by antigene RNAs" Nature Chemical Biology 1, 216-222. Corey, D. R. (2005) "Regulating Mammalian Transcription with RNA" Trends Biochem. Sci 30, 655-658. Hardy, D. B., Janowski, B. A., Corey, D. R., and Mendelson, C. R. (2006). "Progesterone impairs the interleukin-1� (IL-1�) stimulation of cyclooxygenase 2 (COX-2) gene expression in human myometrial cells." Mol. Endo. 20, 2724-2733. Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Nordsell, R., Shames, D. S., Minna, J. D., and Corey, D. R. (2006) "Ago1 and Ago2 link mammalian transcriptional silencing with RNAi." Nature Structural Molecular Biology 13, 787-792. Janowski, B. A., Hu, J., and Corey, D. R. (2006) "Antigene inhibition by peptide nucleic acids and duplex RNAs" Nature Protocols 1, 436-443. Janowski, B. A., Younger, S. T., Hardy, D. B., Ram, R., Huffman, K. E., and Corey, D. R. (2007) 揂ctivating gene expression in mammalian cells with promoter-targeted duplex RNAs.� Nat. Chem. Biol. 3 166-173. Hu, J. and Corey, D. R. (2007) "Inhibiting Gene Expression with PNA-Peptide Conjugates that Target Chromosomal DNA" Biochemistry in Press. Beane, R., Ram, R., Gabillet, S., Arar, K., Monia, B., and Corey D. R. (2007) 揑nhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA� Biochemistry in Press. Corey, D. R. (2007) 揜NAi learns from antisense.� Nat. Chem. Biol. 3, 8-11. Schwartz JC, Younger ST, Nguyen NB, Hardy DB, Monia BP, Corey DR, Janowski BA. (2008) "Antisense transcripts are targets for activating small RNAs." Nat Struct Mol Biol. 15, 842-848. Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. (2009) "Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs." Nat Biotechnol. 27, 478-484. Younger ST, Pertsemlidis A, Corey DR. (2009) "Predicting potential miRNA target sites within gene promoters." Bioorg Med Chem Lett. 19(14):3791-4 RNAi and agRNAs Braasch, D. A. and Corey, D. R. (2002) 揘ovel Antisense Strategies for Controlling Gene Expression� Biochemistry 41, 4503-4510. Braasch, D. A., Jensen, S., Liu, Y., Arar, K., White, M. A., and Corey, D. R. (2003) 揜NA interference in mammalian cells by chemically modified RNA� Biochemistry 42, 7967-7975. Braasch, D. A., Paroo, Z., Constantinescu, A., Ren, G., Oz, O., Mason, R. P. and Corey, D. R. (2004) "Biodistribution of phosphodiester and phosphorothioate siRNA" Bioorg. Med. Chem. Lett. 14, 1139-1143. Paroo, Z. and Corey D. R. (2004) "Challenges for RNA interference in vivo" Trends Biotech. 22, 390-394. Huffman, K. E. and Corey, D. R. (2005) "Inhibition of Expression of Major Vault Protein Does not Alter Chemoresistance or Drug Localization in Cancer Cells" Biochemistry 44, 2253-2261. Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. (2005) "Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids" Nature Chemical Biology 1, 210-215. Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Shames, D. S., Minna, J. D., and Corey D. R. (2005) "Inhibiting gene expression at transcription start sites in chromosomal DNA by antigene RNAs" Nature Chemical Biology 1, 216-222.

Corey, D. R. (2005) "Regulating Mammalian Transcription with RNA" Trends Biochem. Sci 30, 655-658.