Chuo Chen, born in Taipei, Taiwan, R.O.C., received his BS degree at National Taiwan University in 1995. Following the completion of his doctoral studies in 2001 at Harvard University under the direction of Prof. Matthew D. Shair, he worked as a HHMI postdoctoral research fellow under the guidance of Prof. Stuart L. Schreiber at Harvard. Dr. Chen joined the faculty at UT Southwestern in 2004 as a Southwestern Medical Foundation Scholar in Biomedical Research, and became Associate Professor in 2010. The focus of his research program is the synthesis of natural products and Hh/Wnt inhibitors. Education Undergraduate National Taiwan University - Taiwan , Chemistry Graduate School Harvard University (2001)

chemical biology natural product synthesis synthetic methodology development

Identification and Characterization of beta-Sitosterol Target Proteins (Invited Article for the 25th Anniversary Symposium-in-Print "Recent Advances in Medicinal Chemistry and Chemical Biology"). Lomenick, B.; Shi, H.; Huang, J.; Chen, C. Bioorg. Med. Chem. Lett. In press, DOI:10.1016/j.bmcl.2015.03.007. (supporting info) Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F (Invited Article for Tetrahedron Letters Symposium-in-Print in Memory of Harry Wasserman). Shi, H.; De, S.; Wang, Q.; Gao, S.; Wang, X.; Chen, C. Tetrahedron Lett. In press, DOI:10.1016/j.tetlet.2014.12.054. (supporting info) An Approach for the Synthesis of Nakamuric Acid (Invited Article for Tetrahedron Symposium-in-Print on Synthesis of Indole/Pyrrole-Containing Natural Products). Wang, X.-L.; Chen, C. Tetrahedron In press, DOI: 10.1016/j.tet.2014.10.027. (supporting info) Syntheses of Cyclic Guanidine-Containing Natural Products. Ma, Y.; De, S.; Chen, C. Tetrahedron 2015, 71, 1145–1173. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation. Fan, C.-W.; Chen, B.; Franco, I.; Lu, J.; Shi, H.; Wei, S.; Wang, C.; Wu, X.; Tang, W.; Roth, M. G.; Williams, N. S.; Hirsch, E.; Chen, C.; Lum, L. Chem. Biol. 2014, 21, 1680–1689. Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic Enantiodivergence. Ma, Z.; Wang, X.-L.; Wang, X.; Rodriguez, R. A.; Moore, C. E.; Gao, S.; Tan, X.; Ma, Y.; Rheingold, A. L.; Baran, P. S.; Chen, C. Science 2014, 346, 219–224. Visible Light-Promoted Metal-Free sp3-C–H Fluorination. Xia, J.; Zhu, C.; Chen, C. Chem. Commun. 2014, 50, 11701–11704. Dimeric Pyrrole–Imidazole Alkaloids: Synthetic Approaches and Biosynthetic Hypotheses. Wang, X.; Ma, Z.; Wang, X.-L.; De, S.; Ma, Y.; Chen, C. Chem. Commun. 2014, 50, 8628–8639. Vanadium-Catalyzed C(sp3)–H Fluorination Reactions. Xia, J.-B.; Ma, Y.; Chen, C. Org. Chem. Front. 2014, 1, 468–472. A Simple Method for the Electrophilic Cyanation of Secondary Amines. Zhu, C.; Xia, J.-B.; Chen, C. Org. Lett. 2014, 16, 247–250. Vanadium-Catalyzed Oxidative Strecker Reaction: alpha-C–H Cyanation of para-Methoxyphenyl (PMP)-Protected Primary Amines. Zhu, C.; Xia, J.-B.; Chen, C. Tetrahedron Lett. 2014, 55, 232–234. (supporting info) Visible Light-Promoted Metal-Free C–H Activation: Diarylketone-Catalyzed Selective Benzylic Mono- and Difluorination. Xia, J.-B.; Zhu, C.; Chen, C. J. Am. Chem. Soc. 2013, 135, 17494–17500. Stromal-Epithelial Crosstalk Regulates Kidney Progenitor Cell Differentiation. Das, A.; Tanigawa, S.; Karner, C. M.; Xin, M.; Lum, L.; Chen, C.; Olson, E. N.; Perantoni, A. O.; Carroll, T. J. Nat. Cell Biol. 2013, 15, 1035–1044. Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High Affinity Ligand for STING. Zhang, X.; Shi, H.; Wu, J.; Zhang, X.; Sun, L.; Chen, C.; Chen, Z. J. Mol. Cell 2013, 51, 226–235. The Development of Highly Potent Inhibitors for Porcupine. Wang, X.-L.; Moon, J.; Dodge, M. E.; Pan, X.; Zhang, L.; Hanson, J.; Tuladhar, R.; Ma, Z.; Shi, H.; Williams, N. S.; Amatruda, J.; Carroll, T. J.; Lum, L.; Chen, C. J. Med. Chem. 2013, 56, 2700–2704. Cyclic-GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. Wu, J.; Sun, L.; Chen, X.; Du, F.; Shi, H.; Chen, C.; Chen, Z. J. Science 2013, 339, 826–830. Nakiterpiosin (Chapter 2). Gao, S.; Chen. C. In Total Synthesis of Natural Products–At the Frontiers of Organic Chemistry; Li, J. J., Corey, E. J., Eds.; Springer-Verlag: Berlin/Heidelberg, 2013; pp 25–38. A Biomimetic Route for the Construction of the [4+2] and [3+2] Core Skeletons of the Dimeric Pyrrole-Imidazole Alkaloids and the Asymmetric Synthesis of Ageliferins. Wang, X.; Wang, X.-L.; Tan, X.; Lu, J.; Cormier, K. W.; Ma, Z.; Chen. C. J. Am. Chem. Soc. 2012, 134, 18834–18842. The Chemistry and Biology of Nakiterpiosin. Gao, S.; Wang, Q.; Wang, G.; Lomenick, B; Liu, J.; Fan, C.-W.; Deng, L.-W.; Huang, J.; Lum, L.; Chen. C. Synlett 2012, 23, 2298–2310. A Highly Selective Vanadium Catalyst for Benzylic C–H Oxidation. Xia, J.; Cormier, K. W.; Chen, C. Chem. Sci. 2012, 3, 2240–2245.