Education Graduate School Adam Mickiewicz University-Pol (1997), Chemistry Graduate School Adam Mickiewicz University-Pol (2001), Physical Chemistry Graduate School University of London-Eng (2001), Structural Biology Honors & Awards NARSAD Young Investigator Award (2005)

Research Interest chromatin structure evolution next generation sequencing structural biology

Diffraction data analysis in the presence of radiation damage. Borek D, Cymborowski M, Machius M, Minor W, Otwinowski Z Acta Crystallogr. D Biol. Crystallogr. 2010 Apr 66 Pt 4 426-36 The many faces of radiation-induced changes. Borek D, Ginell SL, Cymborowski M, Minor W, Otwinowski Z J Synchrotron Radiat 2007 Jan 14 Pt 1 24-33 Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog. Borek D, Michalska K, Brzezinski K, Kisiel A, Podkowinski J, Bonthron DT, Krowarsch D, Otlewski J, Jaskolski M Eur. J. Biochem. 2004 Aug 271 15 3215-26 Measurement errors and their consequences in protein crystallography. Borek D, Minor W, Otwinowski Z Acta Crystallogr. D Biol. Crystallogr. 2003 Nov 59 Pt 11 2031-8 Multiparametric scaling of diffraction intensities. Otwinowski Z, Borek D, Majewski W, Minor W Acta Crystallogr., A, Found. Crystallogr. 2003 May 59 Pt 3 228-34 Crystal Structure of Cardiac Troponin C Regulatory Domain in Complex with Cadmium and Deoxycholic Acid Reveals Novel Conformation. Li AY, Lee J, Borek D, Otwinowski Z, Tibbits GF, Paetzel M Journal of molecular biology 2011 Sep Structure and control of the actin regulatory WAVE complex. Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK Nature 2010 Nov 468 7323 533-8 To automate or not to automate: this is the question. Cymborowski M, Klimecka M, Chruszcz M, Zimmerman MD, Shumilin IA, Borek D, Lazarski K, Joachimiak A, Otwinowski Z, Anderson W, Minor W J. Struct. Funct. Genomics 2010 Sep 11 3 211-21 Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain. Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Mühlberger E, Basler CF, Amarasinghe GK J. Mol. Biol. 2010 Jun 399 3 347-57 Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins. Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010 Jun 66 Pt 6 689-92 Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK Nat. Struct. Mol. Biol. 2010 Feb 17 2 165-72 Structure and mechanism of a eukaryotic FMN adenylyltransferase. Huerta C, Borek D, Machius M, Grishin NV, Zhang H J. Mol. Biol. 2009 Jun 389 2 388-400 X-ray diffraction experiment--the last experiment in the structure elucidation process. Chruszcz M, Borek D, Domagalski M, Otwinowski Z, Minor W Adv Protein Chem Struct Biol 2009 77 23-40 Crystal packing of plant-type L-asparaginase from Escherichia coli. Michalska K, Borek D, Hernández-Santoyo A, Jaskolski M Acta Crystallogr. D Biol. Crystallogr. 2008 Mar 64 Pt 3 309-20 Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus. Rezácová P, Borek D, Moy SF, Joachimiak A, Otwinowski Z Proteins 2008 Feb 70 2 311-9 The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly. Rezácová P, Krejciríková V, Borek D, Moy SF, Joachimiak A, Otwinowski Z Proteins 2007 Nov 69 3 679-82 Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H Mol. Cell 2006 Aug 23 3 377-87 Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J Science 2006 Mar 311 5768 1761-4 Crystallization and preliminary crystallographic studies of five crystal forms of Escherichia coli L-asparaginase II (Asp90Glu mutant). Kozak M, Borek D, Janowski R, Jaskólski M Acta Crystallogr. D Biol. Crystallogr. 2002 Jan 58 Pt 1 130-2 Expression, purification and preliminary crystallographic studies of human ketohexokinase.

Kozak M, Hayward B, Borek D, Bonthron DT, Jaskólski M Acta Crystallogr. D Biol. Crystallogr. 2001 Apr 57 Pt 4 586-8