Physical Chemistry

The major long-term theme in my research has been the understanding of the structure-function relationship for biologically relevant biopolymers such as metal-complexed antitumor antibiotics and selected anti-malaric peptides. In a broader sense, I am interested in characterizing natural products with biomedical applications.

Primary research techniques include, but are not limited to, NMR and EPR spectroscopies and molecular modeling for the study of structure and dynamics.

Karam, A. R.; Catari, E. L.; Lopez-Linares, F.; Agrifolio, G.; Albano, C. L.; Diaz-Barrios, A.; Lehmann, T. E.; Pekerar, S. V.; Albornoz, L. A.; Atencio, R.; Gonzales, T.; Ortega, H. B.; Joskowics, P. “Synthesis, characterization and olefin polymerization studies of iron(II) and cobalt(II) catalysis bearing 2,6-bis(pyrazol-1-yl)pyridine and 2,6-bis(pyrazol-1-ylmethyl)pyridine ligands.” Applied catalysis A-General 2005, 280, 165-173.

•Lehmann, T. E. “Structural Studies of Cu(I)-Bleomycin.” J. Biol. Inorg. Chem. 2004, 9, 323-334.

•Lehmann, T. E.; Kroon, G.; Dyson, H. J.; Lorenzo, M. A.; Bermúdez, H.; Pérez. H. “Plasmodium vivax CS Peptides Display Conformational Preferences for Folded Forms in Solution.” J. Pep. Res. 2003, 61, 252-262.

•Teresa Lehmann, Claudio Luchinat, Mario Piccioli. “Redox-Related Chemical Shift Perturbations on Backbone Nuclei of High-Potential Iron Sulfur Proteins.” Inorg. Chem. 2001, 41, 1697-1683.

•Lehmann, T. E. “Molecular Modeling of the Three-Dimensional Structure of Fe(II)-Bleomycin. Are the Co(II) and Fe(II) Adducts Isostructural?” Journal of Biological Inorganic Chemistry (JBIC) 2001, 7, 305-312.

•Navarro, M.; Cisneros-Fajardo, E. J.; Lehmann, T. E.; Sánchez-Delgado, R. A.; Atencio, R.; Silva, P.; Lira, R.; Urbina, J. A. “Toward a Novel Metal Based Chemotherapy Against Tropical Diseases 6. Synthesis and Characterization of New Copper and Gold Clotrimazole and Ketoconazole Complexes and Evaluation of Their Activity Against Trypanosoma Cruzi.” Inorg. Chem. 2001, 40, 6879-6884.

•Navarro, M.; Lehmann, T. E.; Cisneros-Fajardo, E. J.; Fuentes, A.; Sánchez-Delgado, R. A.; Silva, P.; Urbina, J. A. “Toward a Novel Metal Based Chemotherapy Against Tropical Diseases 5. Synthesis and Characterization of New Ru(II) and Ru(III) Clotrimazole and Ketoconazole Complexes and Evaluation of Their Activity Against Trypanosoma Cruzi.” Polyhedron 2000, 19, 2319-2325.

•Lehmann, T. E.; Serrano, M. L.; Que, L. Jr. “Coordination Chemistry of Co(II)-Bleomycin: Its Investigation Through NMR and Molecular Dynamics.” Biochemistry 2000, 39, 3886-3898.

•Pekerar, S.; Lehmann, T. E.; Méndez, B.; Acevedo, A. “Mobility of Asphaltene Samples Studied by 13C NMR Spectroscopy.” Energy&Fuels 1999, 13, 305-308.

•Lehmann, T. E.; Ming, L.- J.; Rosen, M. E.; Que, L. Jr. “NMR Studies of the Paramagnetic Complex Fe(II)-Bleomycin.” Biochemistry 1997, 36, 2807-2816.