Michael Palmer carries out research in biochemistry. His research focuses on the interaction of peptides and proteins with biological membranes. One current area of interest is the action mode of lipopeptide antibiotic daptomycin, as well as the mechanism of bacterial resistance to it. Fluorescence Antibiotics Membranes Lipopeptides Pore-forming toxins Chemistry Department seminar coordinator, 2011-present Chemistry Department Awards Committee, 2008-present Science Building Committee, 2008-15 2000 Habilitation Medical Microbiology, University of Mainz, Germany 1991 Dr. med. (M.D.), University of Mainz, Germany 1987 Approbation als Arzt (Approved Physician), University of Giessen, Germany

Michael Palmer's research focuses on protein-lipid interaction in biological membranes: Structure and function of bacterial pore-forming toxins Structure and function of lipopeptide antibiotics Development of fluorescence methods to study protein-protein and protein-membrane interaction His experiments involve a range of methods including fluorescence, protein chemistry, and molecular biology.

Biomembranes; protein-membrane interactions; bacterial pore-forming proteins; lipopeptide antibiotics; biochemical fluorescence The research in my group focuses on protein-lipid interaction in biological membranes. Main topics are:

Structure and function of bacterial pore-forming toxins Structure and function of lipopeptide antibiotics Development of fluorescence methods to study protein-protein and protein-membrane interaction

Lohani CR, Taylor R, Palmer M, Taylor SD. Solid-phase synthesis and in vitro biological activity of a Thr4→Ser4 analog of daptomycin (2015) Bioorg Med Chem Lett. 25:5490-5494 Lohani CR, Taylor R, Palmer M, Taylor SD. Solid-phase total synthesis of daptomycin and analogs (2015) Org Lett. 17:748-51 Zhang T, Muraih J, Tishbi N, Herskowitz J, Victor RL, Silverman J, Uwumarenogie S, Taylor S, Mintzer E, Palmer M. Cardiolipin prevents membrane translocation and permeabilization by daptomycin (2014) J Biol Chem 289:11584-11591 Zhang T, Muraih J, MacCormick B, Palmer M. Daptomycin forms cation- and size-selective pores in model membranes (2014) Biochim Biophys Acta 1838:2425-2430 Pokrajac L, Harris JR, Sarraf N, Palmer M. Oligomerization and hemolytic properties of the C-terminal domain of pyolysin, a cholesterol-dependent cytolysin (2013) Biochem Cell Biol. 91:59-66