2000. BSC Chemistry. Bogazici University, Istanbul, Turkey 2004. PhD University of Michigan, USA

Biology is a result of evolution. This fact is at the core of research ideas pursued at OSSlab. Headed by Orkun S. Soyer, the lab is interested in understanding the structure and response dynamics of biological systems from an evolutionary perspective and using this understanding to (re)design de novo biological systems. In other words, we are after evolutionary and ecological principles that can explain the structure and dynamics of biological systems and utilising these principles in systems and synthetic biology.

Our science is mostly driven by a desire to follow novel and interesting ideas. Consequently, we work on a broad set of questions and systems. We are a dry/wet lab working both through experiments done in theoretical models and computer simulations, and in real biological systems. On the latter domain, we currently focus on microbial systems, with two key research areas being the analysis and design of signaling and metabolic networks, and understanding and engineering of microbial communities.

Feng, Song, Ollivier, Julien F., Soyer, Orkun S.. 2016. Enzyme sequestration as a tuning point in controlling response dynamics of signalling networks. PLoS Computational Biology, 12 (5), View Steinacher, Arno, Bates, Declan, Akman, Ozgur E., Soyer, Orkun S.. 2016. Nonlinear dynamics in gene regulation promote robustness and evolvability of gene expression levels. PLoS One, 11 (4), View Großkopf, Tobias, Consuegra, Jessika, Gaffé, Joël, Willison, John C., Lenski, Richard E., Soyer, Orkun S., Schneider, Dominique. 2016. Metabolic modelling in a dynamic evolutionary framework predicts adaptive diversification of bacteria in a long-term evolution experiment. BMC Evolutionary Biology, 16 (1), View Montefusco, Francesco, Akman, Ozgur E., Soyer, Orkun S., Bates, Declan. 2016. Ultrasensitive negative feedback control : a natural approach for the design of synthetic controllers. PLoS One, 11 (8), View Cizmeci, Deniz, Dempster, Emma L., Champion, Olivia L., Wagley, Sariqa, Akman, Ozgur E., Prior, Joann L., Soyer, Orkun S., Mill, Jonathan, Titball, Richard W.. 2016. Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Scientific Reports, 6, View Feng, Song, Sà¡ez, Meritxell, Wiuf, Carsten, Feliu, Elisenda, Soyer, Orkun S.. 2016. Core signalling motif displaying multistability through multi-state enzymes. Journal of The Royal Society Interface, 13 (123), View Großkopf, Tobias, Soyer, Orkun S.. 2016. Microbial diversity arising from thermodynamic constraints. The ISME Journal, 10, pp. 2725-2733, View Großkopf, Tobias, Zenobi, Simone, Alston, Mark, Folkes, Leighton, Swarbreck, David, Soyer, Orkun S.. 2016. A stable genetic polymorphism underpinning microbial syntrophy. The ISME Journal, 10, pp. 2844-2853, View