Mass spectrometry based comparative metabolomics and proteomics, their applications in natural product drug discovery (identification, purification and structure elucidation), drug mechanism of action and metabolism analysis (ADME, pharmacokinetics), disease biomarker discovery and validation (for therapeutic and pharmacodynamics study).

L. Ray, T. Valentic, T. Miyazawa, D. Withall, L. Song, H. Osada, S. Takahashi, S. Tsai, G. Challis, Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics, Nat Comm., 2016, 7, 13609 D. Zabala, J. Cartwright, D. Roberts, B. Law, L. Song, M. Samborskyy, P. Leadlay, J. Micklefield, and G. Challis. A flavin-dependent decarboxylase-dehydrogenase-monooxygenase assembles the warhead of α, β-epoxyketone proteasome inhibitors. J. Am. Chem. Soc. 2016, 137, 432-435 J. Parascandolo, J. Havemann, H. Potter, F. Huang, E. Riva, J. Connolly, I. Wilkening, L. Song, P. Leadlay, M. Tosin, Novel insights into 6-methylsalicylic acid bio-assembly via chemical probes, Angew. Chem. Int. Ed. 2016, 55(10), 3463-3467 Amaratunga, P. Lim, S. Suon, S. Sreng, S. Mao, C. Sopha, B. Sam, D. Dek, V. Try, R. Amato, D. Blessborn, L. Song, G. Tullo, M. Fay, J. Anderson, J. Tarning, R. Fairhurst. Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multi-site observational cohort study, Lancet Infectious Disease, 2016, 16(3), 357-365 N. Liu*, L. Song*, M. Liu*, F. Shang, Z. Anderson, D. Fox, G. L. Challis, Y. Huang, Unique post-translational ­oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264, Chem. Sci., 2016, 7(1), 482-488 (* Co-first author) R. Leang, W. Taylor, D. Bouth, L. Song, J. Tarning, M. Char, S. Kim, B. Witkowski, V. Duru, A. Domergue, N. Khim, P. Ringwald, D. Menard, Evidence of falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label multicenter clinical assessment. Antimicrob Agents Chemother., 2015, 59(8), 4719-4726