We are interested in the development of useful new synthetic methodology of broad utility for organic synthesis. This particularly involves transition metal catalysis, including asymmetric catalysis. Our interests include: 1) Sustainable chemistry for efficient chemical synthesis; 2) Organofluorine chemistry, particularly fluorination using nucleophilic fluoride salts; 3) Metal catalysed reactions that e.g. increase chemical complexity, especially involving asymmetric catalysis 4) Studying the mechanism of metal-catalysed reactions. 5) Bioimaging using 18F Positron Emission Tomography.

A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones C.E. Iacono; T.C.Stephens; T.S. Rajan; G. Pattison* J. Am. Chem. Soc., Article ASAP Conformational preferences of α-fluoroketones may influence their reactivity G. Pattison* Beilstein J. Org. Chem 2017, 13, 2915–2921 Transition-Metal-Free Homologative Cross-Coupling of Aldehydes and Ketones with Geminal Bis(boron) Compounds T.C. Stephens; G.Pattison* Org. Lett., 2017, 19, 3498-3501 Rh-catalyzed arylation of fluorinated ketones with arylboronic acids; Luca S. Dobson and Graham Pattison*, Chem. Commun. 2016, , 52, 11116-11119. One-pot synthesis of difluoromethyl ketones by a difluorination / fragmentation process; Daniel J. Leng, Conor M. Black and Graham Pattison*, Org Biomol. Chem. 2016, 14, 1531-1535. Apparent Electrophilic Fluorination of 1,3-Dicarbonyl Compounds using Nucleophilic Fluoride Mediated by PhI(OAc)2; Toby J. Nash and Graham Pattison*, Eur. J. Org. Chem, 2015, 3779-3786. A second-generation ligand for the enantioselective rhodium-catalyzed addition of arylboronic acids to alkenylazaarenes Iain D. Roy, Alan R. Burns, Graham Pattison, Boris Michel, Alexandra Parker and Hon Wai Lam, Chem. Commun. 2014, 50, 2865-2868. Enantioselective Rh(I)-Catalyzed Cyclization of Arylboron Compounds onto Ketones Darryl W. Low, Graham Pattison, Martin D. Wieczysty, Gwydion Churchill and Hon Wai Lam; Org. Lett. 2012, 14, 2548-2551. Enantioselective Rhodium-Catalyzed Addition of Arylboronic Acids to Alkenylheteroarenes Graham Pattison, Guillaume Piraux and Hon Wai Lam; J. Am. Chem. Soc. 2010, 132, 14373-14375.