Modelling of biomolecules, biomimetics and the interface between biomolecules and materials, across multiple lengthscales. Key research includes molecular simulations to explore the barrier and elastic properties of skin, biological membrane barriers and membrane transport, and the adsorption of biomolecules onto solid surfaces for a range of applications in healthcare and bionanotechnology.

Permeation of Polystyrene Nanoparticles across Model Lipid Bilayer Membranes T.H.F. Thake, J.R. Webb, A. Nash, J.Z. Rappoport, R. Notman, Soft Matter, 2013, 9, 10265. Nanofibre-Based Delivery of Therapeutic Peptides to the Brain. M. Mazza, R. Notman, J. Anwar, A. Rodger, M. Hicks, G. Parkinson, D. McCarthy, T. Daviter, J. Moger, N. Garrett, T. Mead, M. Briggs, A.G. Schatzein, A.G. and I.F. Uchegbu, ACS Nano, 2013, 7, 1016. Solution Study of Engineered Quartz Binding Peptides using Replica Exchange Molecular Dynamics, R. Notman, E.E. Oren, C. Tamerler, M. Sarikaya, R. Samudrala, T.R. Walsh, Biomacromolecules 2010, 11, 3266. Probing the molecular mechanisms of quartz-binding peptides. E.E. Oren, R. Notman, I.W. Kim, J.S. Evans, T.R. Walsh, R. Samudrala, C. Tamerler, M. Sarikaya, Langmuir 2010, 26, 11003. Molecular dynamics studies of the interactions of water and amino acid analogs with quartz surfaces. R. Notman, T.R. Walsh, Langmuir, 2009, 25, 1638.