Combining organic chemistry and molecular design in the synthesis of functional molecules. Understanding how the molecules we make interact with each other and with biological targets. Synthesis of heterocycles and nucleobase analogues that are able to self-assemble using hydrogen bonds and other non-covalent interactions. Discovery of protein targets for known bioactive molecules using phage display and affinity methods. Synthetic and biomolecular interactions using physico-chemical techniques including isothermal titration calorimetry, gel permeation chromatography and NMR methods.

Simvastatin sodium salt and fluvastatin interact with human gap junction gamma-3 protein A Marsh,* K Casey-Green, F Probert, D Withall, D A Mitchell, S J Dilly, S James, W Dimitri, S R Ladwa, P C Taylor, D R J Singer PLOS ONE 2016, DOI: 10.1371/journal.pone.0148266 G4-Quartet•M+ Borate Hydrogels. G M Peters, L P Skala, T N Plank, H Oh, G N M Reddy, A Marsh, S P Brown, S R Raghavan, and J T Davis* J. Am. Chem. Soc. 2015, 137, doi:10.1021/jacs.5b02753 Templated polymerizations on solid supports mediated by complementary nucleoside interactions. M Garcia, K Kempe, D M Haddleton,* A Khan, A Marsh* Polymer Chem 2015 DOI: 10.1039/c4py01783h A G4•K+ Hydrogel Stabilized by an Anion. G M Peters, L P Skala, T N Plank, B J Hyman, G N Manjunatha Reddy, A Marsh, S P Brown, and J T Davis* J. Am. Chem. Soc. 2014, 136, 12596−12599. doi:10.1021/ja507506c Use of freely available and open source tools for in silico screening in Chemical Biology. G W Price, P S Gould, A Marsh J. Chem. Educ., 2014 doi:10.1021/ed400302u. Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation. A Millard, D J Scanlan,* C Gallagher, A Marsh, P C Taylor* Molecular BioSystems 2014 10, 380 - 383. DOI: 10.1039/c3mb70447e. Nanostructures from tertiary amine N-oxide amphiphiles: M P Beecham, G J Clarkson, G Hall, A Marsh* ChemPhysChem, 2013, 14, 3909-3915. DOI:10.1002/cphc.201300775 A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins. P C Taylor,* A J Clark, A Marsh, D R J Singer, S J Dilly Chem. Commun., 2013, 49, 9588-9590. DOI: 10.1039/c3cc44647f. Oxidation of tertiary amine derivatised surfaces to control protein adhesion: D A Dobrzanska, A L Cooper, C G Dowson, S D Evans, D J Fox, B R Johnson, C I Biggs, R K Randev, H M Stec, P C Taylor, A Marsh* Langmuir, 2013, 29, 2961–2970. doi: 10.1021/la4003719.