Synthetic organic and medicinal chemistry

- Drug Discovery for inflammatory diseases, such as for asthma, and degenerative and metabolic diseases.

- Synthetic methodology including asymmetric and catalytic reactions, kinetics and DFT modelling.

Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines Perryman, Michael S.; Harris, Matthew E.; Foster, Jade L.; Joshi, Anushka; Clarkson, Guy J.; Fox, David J. Chem Commun., 2013, 49, 10022-10024. DOI:10.1039/c3cc46070c This paper was highlighted in Synfacts 2014, 10, 175. DOI:10.1055/s-0033-1340532 Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study Morrill, Louis C.; Douglas, James; Lebl, Tomas; Slawin, Alexandra M. Z.; Fox, David J.; Smith, Andrew D. Chemical Science, 2013, 4, 4146-4155. DOI:10.1039/c3sc51791h Iron/Tetramethylethylenediamine-Catalyzed Ambient-Temperature Coupling of Alkyl Grignard Reagents and Aryl Chlorides Rushworth, Philip J.; Hulcoop, David G.; Fox, David J. J. Org. Chem., 2013, 78, 9517-9521. DOI: 10.1021/jo4016612 Highly potent, orally-available anti-inflammatory broad-spectrum chemokine inhibitors D.J. Fox, J. Reckless, H. Lingard, S. Warren and D.J. Grainger, J. Med. Chem. 2009, 52, 3591–3595. DOI: 10.1021/jm900133w Anti-inflammatory composition comprising 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one D. J. Grainger and D. J. Fox WO2009016390A1 Mechanism of Catalytic Cyclohydroamination by Zirconium Salicyloxazoline Complexes L. E. N. Allan, G. J. Clarkson, D. J. Fox, A. L. Gott, and P. Scott, J. Am. Chem. Soc., 2010, 132, 15308–15320. DOI: 10.1021/ja106588m