Ph.D. D.S. University of Strasbourg, France 1973 & 1976 M.Sc. University of Strasbourg, France 1971

Biotechnology Genetics Microbiology Molecular Biology

“Research interests lie in the area of the molecular biology of plant and human viruses. Development of “”transgenic”” plants resistant to viruses: mechanisms of resistance. Genome organization, self-splicing (Ribozyme) and replication strategies of some viruses and their satellite RNAs. Development of recombinant vaccines produced in plants. Plant antiviral proteins for gene therapy of AIDS. Molecular mechanisms involved in the translation in Pro- and Eukaryotes: alternative modes of initiation of translation. Development of vaccines (e.g. HCV).”

Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt.AbouHaidar MG, Venkataraman S, Golshani A, Liu B, Ahmad T.Proc. Natl. Acad. Sci. U.S.A. 2014 Sep; pubmed Viral and chloroplastic signals essential for initiation and efficiency of translation in Agrobacterium tumefaciens.Ahmad T, Venkataraman S, Hefferon K, AbouHaidar MG.Biochem. Biophys. Res. Commun. 2014 Sep;452(1):14-20 pubmed Recent patents involving virus nucleotide sequences; host defense, RNA silencing and expression vector strategies.Ahmad T, AbouHaidar M, Hefferon KL.Recent Pat DNA Gene Seq 2011 Dec;5(3):202-13 pubmed Structural and sequence integrity are essential for the replication of the viroid-like satellite RNA of lucerne transient streak virus.Gellatly D, Mirhadi K, Venkataraman S, AbouHaidar MG.J. Gen. Virol. 2011 Jun;92(Pt 6):1475-81 pubmed Investigating the in vivo activity of the DeaD protein using protein-protein interactions and the translational activity of structured chloramphenicol acetyltransferase mRNAs.Butland G, Krogan NJ, Xu J, Yang WH, Aoki H, Li JS, Krogan N, Menendez J, Cagney G, Kiani GC, Jessulat MG, Datta N, Ivanov I, Abouhaidar MG, Emili A, Greenblatt J, Ganoza MC, Golshani A.J. Cell. Biochem. 2007 Feb;100(3):642-52 pubmed Escherichia coli mRNAs with strong Shine/Dalgarno sequences also contain 5' end sequences complementary to domain # 17 on the 16S ribosomal RNA.Golshani A, Krogan NJ, Xu J, Pacal M, Yang XC, Ivanov I, Providenti MA, Ganoza MC, Ivanov IG, AbouHaidar MG.Biochem. Biophys. Res. Commun. 2004 Apr;316(4):978-83 pubmed Induction of innate immunity by IL-2-expressing Salmonella confers protection against lethal infection.al-Ramadi BK, Mustafa N, AbouHaidar M, Fernandez-Cabezudo MJ.Mol. Immunol. 2003 Mar;39(13):763-70 pubmed Inability of Agrobacterium tumefaciens ribosomes to translate in vivo mRNAs containing non-Shine-Dalgarno translational initiators.Golshani A, Xu J, Kolev V, Abouhaidar MG, Ivanov IG.Z. Naturforsch., C, J. Biosci. 2002 Mar-Apr;57(3-4):307-12 pubmed