B. S. 1999, Yonsei University M. S. 2001, Yonsei University (Advisor: Injae Shin, Ph.D.) Ph.D. 2009, UT Southwestern Medical Center (Advisor: Thomas Kodadek, Ph.D.) PostDoc. 2012, The Scripps Research Institute (Advisor: Jeffery W. Kelly, Ph.D.)

Chemical Biology

Our research goal is to develop novel chemical biology technologies and small molecules in order to probe the molecular mechanisms of cancer metastasis, drug resistance, and recurrence. Current projects include:

Construction of novel combinatorial chemical libraries. Discovery of novel small molecule modulators of autophagy for the treatment of cancers and neurodegenerative diseases. Discovery of small molecule modulators of cancer stem cells.

Palhano, F. L., Lee, J., Grimster, N. P., Kelly, J. W. “Toward the molecular mechanism(s) by which EGCG treatment remodels matureamyloid fibrils” J. Am. Chem. Soc., 2013, 135, 7503-7510.

Lee, J., Culyba, E. K., Powers, E. T., Kelly, J. W. “Amyloid-β forms fibrils bynucleated conformational conversion of oligomers” Nature Chemical Biology, 2011, 7, 602-609. * Featured in Nature Chemical Biology News and Views: “FlAsH illuminates Aβ aggregation”, by Tiago F Outeiro. * Evaluated in Faculty of 1000 by Alan Saghatelian.

Lee, J., Udugamasooriya, D. G., Lim, H-S., Kodadek, T. “Potent and selective photo-inactivation ofproteins with peptoid-ruthenium conjugates” Nature Chemical Biology, 2010, 6(4), 258-260. * Evaluated in Faculty of 1000 by Divya Krishnamurthy, Amy Barrios, and Ross Weatherman.

Lee, J., Reddy, M. M., Kodadek, T. “Discovery of an orexin receptor positive potentiator” Chemical Science, 2010, 1(1), 48-54. * Featured as an inside cover article.

Jung, H. J., Shim, J. S., Lee, J., Song, Y. M., Park, K. C., Choi, S. H., Kim, N. D., Yoon, J. H., Mungai, P. T., Schumacker, P. T., Kwon, H. J. “Terpestacin inhibits tumor angiogenesis by targeting UQCRBof mitochondrial complex III and suppressing hypoxia-induced reactive oxygenspecies production and cellular oxygen sensing” J. Biol. Chem. 2010, 285(15), 11584-11595 * Evaluated in Faculty of 1000 by Jeremy Ward

Gocke, A. R., Archer, C. T., Udugamasooriya, D. G., Lee, J., Kodadek, T. “Isolation of antagonists of antigen-specific autoimmune T cellproliferation” Chemistry & Biology, 2009, 16(11), 1133-1139.

Lee, J., Yu, P., Xiao, X., Kodadek, T. “A general system for evaluating the efficiency ofchromophore-assisted light inactivation (CALI) of proteins reveals Ru(II)tris-bipyridyl as an unusually efficient warhead” Molecular BioSystems. 2008, 4, 59-65. *Selected as a “Hot article” in Molecular BioSystems. * Featured in Highlight in Chemical Biology: “Bringing warhead efficiency to light”, by Russell Johnson

Shim, J. S., Park, H. M., Lee, J., Kwon, H. J. “Globaland focused transcriptional profiling of small molecule aminopeptidase Ninhibitor reveals its mechanism of angiogenesis inhibition” Biochem. Biophys. Res. Commun. 2008, 371(1), 99-103

Shim, J. S., Lee, J., Kim, K. N., Kwon, H. J. “Developmentof a new Ca2+/calmodulin antagonist and its anti-proliferativeactivity against colorectal cancer cells” Biochem. Biophys. Res. Commun. 2007, 359(3), 747-751.

Kim, D. H.*, Lee, J.*, Kwon. H. J. “Anti-tumoractivity of N-hydroxy-7-(2-naphthylthio)heptanomide, a novel histonedeacetylase inhibitor” Biochem. Biophys. Res. Commun. 2007, 356(1), 233-238.

Lee, J., Shim, J. S., Jung, S-A., Lee, S-T., Kwon, H. J. “N-Hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamateinhibitor of aminopeptidase N and itsanti-angiogenic activity” Bioorg. Med. Chem. Lett. 2005, 15(1), 181-183.

Yoo, H., Kim, S. H., Lee, J., Kim H. J., Seo, S. H., Chung, B. Y., Jin, C., Lee, Y. S. “Synthesis and antioxidant activity of3-methoxyflavones” Bull. Kor. Chem. Soc. 2005, 26(12), 2057-2060

Kim, K. N., Lee, J., Kim, D. H., Yoo, J-S., Kwon, H. J. “A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-tymidine,inhibits the proliferation of tumor cells” Bioorg. Med. Chem. Lett. 2005, 15(1), 77-79.

Shim, J. S., Lee, J., Park, H-J., Park, S-J., Kwon, H. J. “A new curcumin derivatives, HBC, interferes with the cell cycleprogression of colon cancer cells via antagonization of the Ca2+/calmodulinfunction” Chemistry & Biology 2004, 11, 1455-1463.

Shim, J. S., Kim, J. H., Lee, J., Kim, S. N., Kwon, H. J. “Anti-angiogenic activity of the homoisoflavanone from Cremastra appendiculata” Planta Medica 2004, 70(2), 171-173.

Cho, M-K., Kim, S-S., Lee, M. R., Shin, J., Lee, J., Lim, S-K., Baik, J-H., Yoon, C-J., Shin, I., Lee, W. “NMR studies on turn mimetic analogs derived from melanocytestimulating hormones” J. Biochem. Mol. Biol. 2003, 36, 552-557.

Lee, M. R., Lee, J., Baek, B-H., Shin, I. “The first solid-phase synthesis of oligomeric a-aminooxy peptides” Synlett 2003, 3, 325.

Dok-Go, H., Lee, K. H., Kim, H. J., Lee, E. H., Lee, J., Song, Y. S., Lee, Y., Jin, C., Lee, Y. S., Cho, J. “Neuroprotective effects ofantioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin3-methyl ether, isolated from opuntiaficus-indica var saboten” Brain Research 2002, 965, 130-136

Lee, M. R., Lee, J., Shin, I. “Synthesis of novel glycopeptidomimetics containing O- and N-glycosylated a-aminooxy acids by fragment coupling on solid support” Synlett 2002, No.9, 1463.

Shin, I., Lee, M, R., Lee, J., Jung, M., Lee, W., Yoon, J. “Synthesis of optically active phthaloyl D-aminooxy acids from L-aminoacids or L-hydroxy acids as building blocks for the preparation of aminooxypeptides” J. Org. Chem. 2000, 65(22), 7667-7675.