Grewal, Thomas 照片

Grewal, Thomas

Associate Professor

所属大学: University of Sydney

所属学院: Faculty of Pharmacy

邮箱:
thomas.grewal@sydney.edu.au

个人主页:
http://sydney.edu.au/pharmacy/about/people/profiles/thomas.grewal.php

研究领域

Regulation of EGFR/Ras signalling and trafficking. Ras signaling and stimulation of cholesterol efflux in atherosclerosis. Role of Annexin A6 in cholesterol export from late endosomes and caveolae/lipid raft formation.

近期论文

Tran, J., Magenau, A., Rodriguez, M., Rentero, C., Royo, T., Enrich, C., Thomas, S., Grewal, T., Gaus, K. (2016). Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. PloS One, 11(3), 1-20. [More Information] Garcia-Melero, A., Reverter, M., Hoque, M., Meneses-Salas, E., Koese, M., Conway, J., Johnsen, C., Alvarez-Guaita, A., Morales-Paytuvi, F., Elmaghrabi, Y., Grewal, T., et al (2016). Annexin A6 and late endosomal cholesterol modulates integrin recycling and cell migration. The Journal of Biological Chemistry, 291(3), 1320-1335. [More Information] Meier, E., Rein-Fischboeck, L., Pohl, R., Wanninger, J., Hoy, A., Grewal, T., Eisinger, K., Krautbauer, S., Liebisch, G., Weiss, T., et al (2016). Annexin A6 protein is downregulated in human hepatocellular carcinoma. Molecular and Cellular Biochemistry, 418(1-2), 81-90. [More Information] Cornley, R., Pollock, A., Rentero, C., Norris, S., Alvarez-Guaita, A., Grewal, T., Mitchell, T., Enrich, C., Moss, S., Parton, R., et al (2016). Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunology and Cell Biology, 94(6), 543-553. [More Information] Chan, T., Cheung, F., Zheng, J., Lu, X., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2016). Casein Kinase 2 Is a Novel Regulator of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Trafficking. Molecular Pharmaceutics, 13(1), 144-154. [More Information] Munoz, L., Yeung, Y., Grewal, T. (2016). Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells. Cancer Biology and Therapy, 17(4), 355-363. [More Information] Lasrich, D., Bartelt, A., Grewal, T., Heeren, J. (2015). Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes. Experimental Cell Research, 337(1), 94-102. [More Information] Alvarez-Guaita, A., Vila de Muga, S., Owen, D., Williamson, D., Magenau, A., Garcia-Melero, A., Reverter, M., Hoque, M., Cairns, R., Cornely, R., Grewal, T., et al (2015). Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. British Journal of Pharmacology, 172(7), 1677-1690. [More Information] Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information] Chan, T., Zheng, J., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2015). Putative Transmembrane Domain 6 of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Influences Transporter Substrate Binding, Protein Trafficking, and Quality Control. Molecular Pharmaceutics, 12(1), 111-119. [More Information] Enrich, C., Rentero, C., Hierro, A., Grewal, T. (2015). Role of cholesterol in SNARE-mediated trafficking on intracellular membranes. Journal of Cell Science, 128(6), 1071-1081. [More Information] Hoque, M., Rentero, C., Conway, J., Murray, R., Timpson, P., Enrich, C., Grewal, T. (2015). The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking. Cell adhesion & migration, 9(5), 384-391. [More Information] Gurgis, F., Yeung, Y., Tang, M., Heng, B., Buckland, M., Ammit, A., Haapasalo, J., Haapasalo, H., Guillemin, G., Grewal, T., Munoz, L. (2015). The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells. Oncogene, 34(22), 2934-2942. [More Information] Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information] Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information] Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information] Musiol, A., Gran, S., Ehrhardt, C., Ludwig, S., Grewal, T., Gerke, V., Rescher, U. (2013). Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation. MBIO, 4(6), 1-11. [More Information] Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information] Poeter, M., Radke, S., Koese, M., Hessner, F., Hegemann, A., Musiol, A., Gerke, V., Grewal, T., Rescher, U. (2013). Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1833 (7), 1700-1711. [More Information] Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]