Adrenal steroid metabolism, 11beta hydroxysteroid dehydrogenases, steroid hormone action, basic and clinical bone research.

Gargya, A., Chua, E., Hetherington, J., Sommer, K., Cooper, M. (2016). Acute adrenal insufficiency: An aide-memoire of the critical importance of its recognition and prevention. Internal Medicine Journal, 46(3), 356-359. [More Information] Juarez, M., McGettrick, H., Scheel-Toellner, D., Yeo, L., Spengler, J., de Paz, B., Hardy, R., Cooper, M., Raza, K., Buckley, C., et al (2016). DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system. Arthritis Research & Therapy, 18, 1-6. [More Information] Cooper, M., Seibel, M., Zhou, H. (2016). Glucocorticoids, bone and energy metabolism. Bone, 82, 64-68. [More Information] Schulz, J., Frey, K., Cooper, M., Zopf, K., Ventz, M., Diederich, S., Quinkler, M. (2016). Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency. Journal of Applied Physiology, 174(4), 531-538. [More Information] Tu, J., Zhang, Y., Kim, S., Wiebe, E., Spies, C., Buttgereit, F., Cooper, M., Seibel, M., Zhou, H. (2016). Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts Attenuates Joint Inflammation in Collagen Antibody - Induced Arthritis. The American Journal of Pathology, 186(5), 1293-1301. [More Information] Nanus, D., Filer, A., Yeo, L., Scheel-Toellner, D., Hardy, R., Lavery, G., Stewart, P., Buckley, C., Tomlinson, J., Cooper, M., et al (2015). Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis. Arthritis Research & Therapy, 17(121), 1-10. [More Information] Venkatesh, B., Cohen, J., Cooper, M. (2015). Ten false beliefs about cortisol in critically ill patients. Intensive Care Medicine, 41(10), 1817-1819. [More Information] Nanus, D., Filer, A., Hughes, B., Fisher, B., Taylor, P., Stewart, P., Buckley, C., McInnes, I., Cooper, M., Raza, K. (2015). TNFα regulates cortisol metabolism in vivo in patients with inflammatory arthritis. Annals of the Rheumatic Diseases, 74(2), 464-469. [More Information] Dancer, R., Parekh, D., Lax, S., D'Souza, V., Zhing, S., Bassford, C., Park, D., Bartis, D., Mahida, R., Turner, A., Cooper, M., et al (2015). Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax, 70(7), 617-624. [More Information] Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information] Hardy, R., Raza, K., Cooper, M. (2014). Glucocorticoid metabolism in rheumatoid arthritis. Annals of the New York Academy of Sciences, 1318 (1), 18-26. [More Information] Cooper, M. (2014). Role of endocrine dysfunction in frequently unexplained disorders. European Journal of Pain, 18(3), 299-300. [More Information] Doig, C., Bashir, J., Zielinska, A., Cooper, M., Stewart, P., Lavery, G. (2014). TNFa-mediated Hsd11b1 binding of NF-kB p65 is associated with suppression of 11B-HSD1 in muscle. The Journal of Endocrinology, 220(3), 389-396. [More Information] Gathercole, L., Lavery, G., Morgan, S., Cooper, M., Sinclair, A., Tomlinson, J., Stewart, P. (2013). 11Beta -Hydroxysteroid Dehydrogenase 1: Translational and Therapeutic Aspects. Endocrine Reviews, 34(4), 525-555. [More Information] Tiganescu, A., Tahrani, A., Morgan, S., Otranto, M., Desmouliere, A., Abrahams, L., Hassan-Smith, Z., Walker, E., Rabbitt, E., Cooper, M., et al (2013). 11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. Journal of Clinical Investigation, 123(7), 3051-3060. [More Information] Hardy, R., Hulso, C., Liu, Y., Gasparini, S., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P., Raza, K., Cooper, M., Seibel, M., Zhou, H. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Research & Therapy, 15(1), 1-14. [More Information] Crabtree, N., Hogler, W., Cooper, M., Shaw, N. (2013). Diagnostic evaluation of bone densitometric size adjustment techniques in children with and without low trauma fractures. Osteoporosis International, 24(7), 2015-2024. [More Information] Seibel, M., Cooper, M., Zhou, H. (2013). Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. The Lancet Diabetes & Endocrinology, 1(1), 59-70. [More Information] Cooper, M., Thickett, D., Stewart, P. (2013). Reduced cortisol metabolism during critical illness. The New England Journal of Medicine, 369(5), 480-480. [More Information] Hardy, R., Seibel, M., Cooper, M. (2013). Targeting 11beta-hydroxysteroid dehydrogenases: a novel approach to manipulating local glucocorticoid levels with implications for rheumatic disease. Current opinion in pharmacology, 13(3), 440-444. [More Information]