John McVey is Professor of Cardiovascular Biology at the University of Surrey and holds an Honorary Professorship at University College London (UCL). His research focuses on the regulation of blood coagulation and the role that coagulation factors play in normal physiology and in the pathophysiology of disease. Professor McVey has published in excess of 120 research articles, reviews, and books. He has received major grant funding from the MRC, Wellcome Trust, BBSRC and BHF. He is a named inventor on 3 patents. He is a fellow of the Royal College of Pathologists.

Visiting Professor: Kings College London; 2011-2013 Weston Professor of Molecular Medicine: Thrombosis Research Institute; 2008 to 2011 Group Leader: MRC Clinical Sciences Centre, Haemostasis and Thrombosis; 2006 to 2008 Honorary Reader in Haemostasis & Thrombosis: Imperial College London; 2006-2008 Postdoctoral Research Scientist: MRC CSC, Haemostasis and Thrombosis; 1987 to 2006 Postdoctoral Research Scientist: National Institute for Medical Research, London; 1984 1987 Postdoctoral Research Scientist: Courtauld Institute of Biochemistry, London; 1982 1984 Postgraduate Research Student: Beatson Institute for Cancer Research, Glasgow; 1979-1982

Studies on the initiation of blood coagulation in disease models • Development of novel anticoagulant strategies • Gene therapy for inherited coagulation factor disorders • Genetic and functional studies in inherited coagulation disorders • Role of coagulation factors in modulating delivery of adenoviral gene therapy vectors

Waddington,S.N., *McVey,J.H., Bhella,D., Parker,A.L., Barker,K., Atoda,H., Pink,R., Buckley,S.M.K., Greig,A., Denby,L., Custers,J., Morita,T., Francischetti,I.M.B., Monteiro,R.Q., Barouch,D.H., van Rooijen,N., Napoli,C., Havenga,M., Nicklin,S.A. and Baker,A.H. (2008) A critical role for the adenovirus serotype 5 hexon in liver gene transfer. Cell. 132, 397-409. *Joint first author. Alba,R., Bradshaw,A.C., Parker,A.L., Bhella,D., Waddington,S.N., Nicklin,S.A., van Rooijen,N., Custers,J., Goudsmit,J., Barouch,D.H., McVey,J.H., and Baker,A.H. (2009) Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood 114, 965-971. Chen,D., Carpenter,A., Abrahams,J., Chambers,R.C., Lechler,R.I., McVey,J.H. and Dorling,A. (2008) Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo. J. Exp Med. 205, 1739-1746. Alba,R., Bradshaw,A.C., Coughlan,L., Denby,L., McDonald,R.A., Waddington,S.N., Buckley,S., Greig,J.A., Parker,A.L., Miller,A.M., Wang,H., Lieber,A., van Rooijen,N., McVey,J.H., Nicklin,S.A. and Baker,A.H. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood 116, 2656-2664. Ward,N.J., Buckley,S.M.K., Waddington,S.N., VandenDriessche,T., Chuah,M.K.L., Nathwani,A.C., McIntosh,J., Tuddenham,E.G.D., Kinnon,C., Thrasher,A.J. and McVey,J.H. (2011) Correction of hemophilia A using codon optimized B-domain variants. Blood 117, 798-807. Lin,CC., Chen, D., McVey,J.H., Cooper,D.K. and Dorling,A. (2008) Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells. Transplantation 86, 702-709. Wang,H., Liu,Y., Li,Z., Tuve,S., Stone,D., Kalyushniy,O., Shayakhmetov,D., Verlinde,CL., Stehle,T., McVey,J., Baker,A., Peng,KW., Roffler,S., and Lieber,A. (2008) In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46. J. Virol. 82, 10567-10579. Greig,J.A., Buckley,S.M.K., Waddington,S.N., Parker,A.L., Bhella,D., Pink,R., Rahim,A.A., Morita,T., Nicklin,S.A., McVey,J.H., and Baker,A.H. (2009) Influence of coagulation factor X on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35 and chimeric Ad5/Ad35 Vectors. Molecular Therapy 17, 1683-1691. Parker,A.L., Waddington,S.N., Buckley,S.M.K., Custers,J., Havenga,M.J.E., van Rooijen,N., Goudsmit,J., McVey,J.H., Nicklin,S.A. and Baker,A.H. (2009) Effect of neutralising sera on factor X-mediated adenoviral serotype 5 gene transfer. J. Virol. 83, 479-483. Chen,D., Abrahams,J., Smith,L., McVey,J.H., Lechler,R.I. and Dorling,A. (2008) Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors.Blood. 111, 4155-4164.