2014 Lecturer in Virus/Host Interactions Department of Microbial & Cellular Sciences. University of Surrey 2011-2013 Post-doctoral Researcher. PI: Prof. Geoffrey L. Smith Department of Pathology. University of Cambridge 2009-2011 Post-doctoral Fellow. PI: Prof. Geoffrey L. Smith Department of Virology. Imperial College London 2008-2009 Post-doctoral Researcher. PI: Dr. Claude Krummenacher Department of Biochemistry. University of Pennsylvania 2007-2008 Research Assistant Professor. PI: Prof. Rosina Girones Department of Microbiology. University of Barcelona 2007 Ph.D. PI: Prof. Rosina Girones Department of Microbiology. University of Barcelona

Viruses are intracellular parasites that have co-evolved with life for millions of years. Some viruses are the cause of common, and sometimes lethal, diseases in humans and animals. My laboratory is interested in how double-stranded DNA viruses (group I of the Baltimore classification) interact with the host cell and manipulate the host immune response to propagate and cause pathogenesis. In particular, we study poxviruses and herpesviruses as models to understand viral immune evasion and alteration of cellular signalling. These viruses have large coding capacity and display a wide range of strategies to interfere with the infected cell. Elucidating such strategies teaches us about the viral life cycle itself and the host anti-viral response, and has the potential to identify targets for anti-viral interventions and improve the rational design of viral vectors for vaccine and oncolytic therapies.

Neidel S, Maluquer de Motes C, Mansur DS, Strnadova P, Smith GL, Graham SC. (2015) 'Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family.'. J Biol Chem, United States: 290 (10), pp. 5991-6002. doi: 10.1074/jbc.M114.624650 Ren H, Ferguson BJ, Maluquer de Motes C, Sumner RP, Harman LE, Smith GL. (2014) 'Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor.'. Immunology, England: 145 (1), pp. 34-49. doi: 10.1111/imm.12422 Veyer DL, Maluquer de Motes C, Sumner RP, Ludwig L, Johnson BF, Smith GL. (2014) 'Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection.'. J Gen Virol, England: 95 (Pt 12), pp. 2757-2768. doi: 10.1099/vir.0.068833-0 Maluquer de Motes C, Schiffner T, Sumner RP, Smith GL. (2014) 'Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues.'. J Gen Virol, England: 95 (Pt 9), pp. 2038-2049. doi: 10.1099/vir.0.065664-0