Our current research is focused on optimal design of drug eluting stents (DES), used for the treatment of coronary artery disease, and is funded by the Engineering and Physical Sciences Research Council. Our approach involves both experimental and mathematical models to help understand the phenomena governing drug transport from the stent surface and through the vessel wall. From this approach we have identified key parameters which influence DES performance and are applying this knowledge to the DES design process.

Modelling the impact of atherosclerosis on drug release and distribution from coronary stentsMcKittrick C.M., Kennedy S., Oldroyd K. G., McGinty S., McCormick C.Annals of Biomedical Engineering Vol 44, pp. 477-487, (2015)http://dx.doi.org/10.1007/s10439-015-1456-7 Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemiaMcKittrick Craig M., Lawrence Catherine E., Carswell Hilary V.O.Journal of Cerebral Blood Flow and Metabolism Vol 35, pp. 638-647, (2015)http://dx.doi.org/10.1038/jcbfm.2014.239