Dr Athanasios (Thanos) Papakyriakou is Marie Curie Research Fellow within the groups of Dr Joern Werner and Prof Tim Elliott. Their proposed research entitled “DynOMIS: Dynamic Origins of MHC class I Selector function” aims to elucidate the antigen selection mechanisms of the adaptive immune system at the molecular level, by integrating experimental investigations of the structure and dynamics of peptide-bound MHC-I over a large range of timescales with state-of-the-art molecular dynamics simulations and free energy calculations.

Computational study of protein structure and dynamics. Computer-aided drug design for kinases and zinc metalloproteases.