Career history 2012-present: Professor in Neurochemistry. Biological Sciences, University of Southampton, UK. 2008-2012: Reader. School of Biological Sciences, University of Southampton, UK. 2004-2008: Senior Lecturer. School of Biological Sciences, University of Southampton, UK. 1999-2004: Lecturer. School of Biological Sciences, University of Southampton, UK. 1997-1999: Post doctoral research fellow. Neurophysiology, National Institute for Medical Research, London, UK. 1992-1997: Post doctoral research fellow. Max-Planck Institute for Brain Research, Frankfurt, UK. Academic qualifications 1992: PhD Physiology, Characterization of strychnine binding sites in the rodent spinal cord. University College London, UK. 1987: First Class BSc (Hons) in Physiology and Biochemistry. University of Reading, UK.

Molecular mechanism of synaptic function and dysfunction Synaptic degeneration Genetic models of synaptic and neuronal dysfunction. Molecular regulation of behaviour in model organism C.elegans. Translating understanding in basic neurobiology to drug regulation to clinical conditions. Translating understanding in basic neurobiology to chemical regulation of animal and plant parasites.

Context-dependent regulation of feeding behaviour by the insulin receptor, DAF-2, in Caenorhabditis elegans - Dillon, James, Holden-Dye, Linda, O'connor, Vincent and Hopper, Neil Published:2016Publication:Invertebrate NeuroscienceVolume:16, (4)Page Range:1-10doi:10.1007/s10158-016-0187-2 Selective and compartmentalized myelin expression of HspB5 - Quraishe, Shmma, Wyttenbach, Andreas, Matinyarare, Nyasha, Perry, Victor, Fern, Robert and O'Connor, Vincent Published:2015Publication:NeuroscienceVolume:316Page Range:130-142doi:10.1016/j.neuroscience.2015.12.035PMID:26718604 Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability - Dalliere, N., Bhatla, N., Luedtke, Z., Ma, D.K., Woolman, J., Walker, R., Holden-Dye, L. and O'Connor, V. Published:2015Publication:The FASEB JournalVolume:30, (2)Page Range:836-848doi:10.1096/fj.15-279257PMID:26514165 The cyclooctadepsipeptide anthelmintic emodepside differentially modulates nematode, insect and human calcium-activated potassium (SLO) channel alpha subunits - Crisford, A., Ebbinghaus-Kintscher, U., Schoenhense, E., Harder, A., O'Kelly, I., Ndukwe, K., O'Connor, V., Walker, R., Welz, C. and Holden-dye, L. Published:2015Publication:PLoS Neglected Tropical DiseasesPage Range:1-20doi:10.1371/journal.pntd.0004062PMID:26437177 Metabotropic glutamate receptors: modulators of context-dependent feeding behaviour in C. elegans. - Dillon, James, Franks, Christopher J, Murray, Caitriona, Edwards, Richard J, Calahorro, Fernando, Ishihara, Takeshi, Katsura, Isao, Holden-Dye, Lindy and O'Connor, Vincent Published:2015Publication:The Journal of Biological ChemistryPage Range:1-28doi:10.1074/jbc.M114.606608PMID:25869139