Fontenelle, Clement
Research Fellow
所属大学: University of Southampton
所属学院: Discipline of Chemistry
个人主页:
http://www.southampton.ac.uk/chemistry/about/staff/cf1m11.page?#research
个人简介
2005-2008: BSc (2:1) in Chemistry, UNICAEN, France • 2008-2010: MSc (1st) in Organic Chemistry, UNICAEN, France • 2010-2014: PhD in Organic Chemistry with Prof. Bruno Linclau, University of Southampton, UK (The Synthesis of Polyfluorinated Carbohydrates) • 2015-present: PDRA with Prof. B. Linclau, University of Southampton, UK
研究领域
• Synthesis of small fluorinated alkanols to study intramolecular hydrogen bonding between organofluorine and alcohols • Synthesis of small fluorinated alkanols to study the influence of fluorination on lipophilicity • Synthesis of (poly)fluorinated carbohydrate analogues to study their affinity for some carbohydrate-binding protein receptors (e. g. GLUT1)
近期论文
Design of fluorinated 5-HT4R antagonists: influence of the basicity and lipophilicity toward the 5-HT4R binding affinities - Fontenelle, Clement Q., Wang, Zhong, Fossey, Christine, Cailly, Thomas, Linclau, Bruno and Fabis, Frederic Published:2013Publication:Bioorganic & Medicinal ChemistryVolume:21, (23)Page Range:7529-7538doi:10.1016/j.bmc.2013.08.061