PhD, Biotechnology, Ch Charan Singh University, 2006 PhD, Biotechnology, Ch.Ch.Singh University, 2006

1. Molecular mechanisms underlying learning-dependent modulation of ingestive behavior. Main goal of this project is to understand the complete mechanisms of the molecular events (e.g. networks of genes) in the brain (e.g. networks of neurons) that underlie hedonic coding, which will make it possible to pharmacologically increase the palatability of less caloric dense foods (e.g. low sugar/low fat). 2. Ventricular and electrical remodeling of heart under hyperoxia-induced stress or metabolic disorder such as Diabetes. 3. Establishing Pharmacogenomics for the FDA approved drugs and implication of personalized medicine for better patient outcome.

Panguluri SK, Tur J, Fukumoto J, Deng W, Sneed KB, Kolliputi N, Bennett ES, Tipparaju SM. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. American journal of physiology. Heart and circulatory physiology. 304(12) : H1651-61, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23585127 Panguluri SK, Tur J, Chapalamadugu KC, Katnik C, Cuevas J, Tipparaju SM. MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators. PloS one. 8(4) : e60545, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23573265 Panguluri SK, Kakar SS. Using quantitative real-time reverse transcriptase polymerase chain reaction to validate gene regulation by PTTG. Methods in molecular biology (Clifton, N.J.). 815: 131-45, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22130989 Bhatnagar S, Panguluri SK, Kumar A. Gene profiling studies in skeletal muscle by quantitative real-time polymerase chain reaction assay. Methods in molecular biology (Clifton, N.J.). 798: 311-24, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22130845 Panguluri SK, Kuwabara N, Kang Y, Cooper N, Lundy RF. Conditioned taste aversion dependent regulation of amygdala gene expression. Physiology & behavior. 105(4) : 996-1006, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22119580 Kumar S, Kumar A, Shah PP, Rai SN, Panguluri SK, Kakar SS. MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines. Journal of ovarian research. 4(1) : 17, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21939554 Paul PK, Gupta SK, Bhatnagar S, Panguluri SK, Darnay BG, Choi Y, Kumar A. Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. The Journal of cell biology. 191(7) : 1395-411, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21187332 Bhatnagar S, Panguluri SK, Gupta SK, Dahiya S, Lundy RF, Kumar A. Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells. PloS one. 5(10) : e13262, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20967264 Panguluri SK, Bhatnagar S, Kumar A, McCarthy JJ, Srivastava AK, Cooper NG, Lundy RF, Kumar A. Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice. PloS one. 5(1) : e8760, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20098732 Pathan FK, Venkata DA, Panguluri SK. Recent patents on antimicrobial peptides. Recent patents on DNA & gene sequences. 4(1) : 10-6, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20218955 Panguluri SK, Kakar SS. Effect of PTTG on endogenous gene expression in HEK 293 cells. BMC genomics. 10: 577, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19958546 Panguluri SK, Yeakel C, Kakar SS. PTTG: an important target gene for ovarian cancer therapy. Journal of ovarian research. 1(1) : 6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19014669 Panguluri SK, Li B, Hormann RE, Palli SR. Effect of ecdysone receptor gene switch ligands on endogenous gene expression in 293 cells. The FEBS journal. 274(21) : 5669-89, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17922837 Panguluri SK, Kumar P, Palli SR. Functional characterization of ecdysone receptor gene switches in mammalian cells. The FEBS journal. 273(24) : 5550-63, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17096690 Panguluri SK, Sridhar J, Jagadish B, Sharma PC, Kumar PA. Isolation and characterization of a green tissue-specific promoter from pigeonpea [Cajanus cajan (L.) Millsp.]. Indian journal of experimental biology. 43(4) : 369-72, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15875723 Bhalla R, Dalal M, Panguluri SK, Jagadish B, Mandaokar AD, Singh AK, Kumar PA. Isolation, characterization and expression of a novel vegetative insecticidal protein gene of Bacillus thuringiensis. FEMS microbiology letters. 243(2) : 467-72, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15686851