2002-present: Professor of Molecular Cell Biology, University of Sheffield 1992-2002: MRC Senior Fellow and Principal Investigator, Wellcome Trust BioCentre, University of Dundee 1989-1992: NATO/SERC postdoctoral fellow, The Scripps Research Institute, California 1986-1989: Postdoctoral research assistant, University of Dundee. 1986: PhD, Trinity College, Dublin 1982: B.A. (Mod), Trinity College, Dublin

Our lab is interested in the molecular mechanisms of cargo sorting along the endocytic pathway with particular emphasis on the regulation of the clathrin coated vesicle cycle by rab5 and reversible phosphorylation. We are also interested in the interplay between endocytic trafficking and signaling pathways.

Smythe E (2015) Role of the rab5 guanine nucleotide exchange factor, Rme-6, in the regulation of clathrin-coated vesicle uncoating. Methods Mol Biol, 1298, 283-293. Fürthauer M & Smythe E (2014) Systems dynamics in endocytosis. Traffic, 15(3), 338-346. Ferreira FJ, Foley M, Cooke A, Cunningham M, Henderson G, Kelly E, Mundell S & Smythe E (2012) Phosphorylation of clathrin light chain b regulates GPCR trafficking. MOLECULAR BIOLOGY OF THE CELL, 23. Dang P, Smythe E & Furley AJ (2012) TAG1 regulates the endocytic trafficking and signaling of the semaphorin3A receptor complex. J Neurosci, 32(30), 10370-10382. Ferreira F, Foley M, Cooke A, Cunningham M, Smith G, Woolley R, Henderson G, Kelly E, Mundell S & Smythe E (2012) Endocytosis of G protein-coupled receptors is regulated by clathrin light chain phosphorylation. Curr Biol, 22(15), 1361-1370. Wright VM, Vogt KL, Smythe E & Zeidler MP (2011) Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. Cell Signal, 23(5), 920-927.