Hornby, David
Professor
所属大学: University of Sheffield
所属学院: Department of Molecular Biology and Biotechnology
个人主页:
http://www.sheffield.ac.uk/mbb/staff/davidhornby/davidhornby
个人简介
Career History
2015 - present: Professor of Biochemistry, Dept. Molecular Biology and Biotechnology 2013 - 2015: Director of Innovation, Liverpool Life Sciences UTC 2012: Professor of Biochemistry Department of Molecular Biology and Biotechnology (on sabbatical leave at the Liverpool School of Tropical Medicine) 2007 - 2012: Head of the Department of Molecular Biology and Biotechnology 2008 - 2011: Director of Enterprise in Life Sciences 1999 - 2007: Professor of Biochemistry Department of Molecular Biology and Biotechnology 1999 - 2002: Director of the Transgenomic Research Laboratory 1998 - 1999: Reader Department of Molecular Biology and Biotechnology 1994 - 1998: Senior Lecturer Department of Molecular Biology and Biotechnology 1992 - 1993: Visiting Scientist Department Molecular Biology The Scripps Research Institute California 1990 - 1994: Lecturer Department of Molecular Biology and Biotechnology 1990: EMBO fellowship Gene Expression Program EMBL, Heidelberg 1986 - 1990: Lecturer Department of Biochemistry 1985 - 1986: Postdoctoral research associate Biozentrum der Universitat Basel, Switzerland 1984 - 1985: Postdoctoral research associate Departments of Biochemistry, Sheffield and Genetics, Leeds 1980 - 1984: PhD (Biochemistry) University of Sheffield 1977 - 1980: BSc Hons (Biochemistry) University of Sheffield
研究领域
Methodology in protein and nucleic acid biochemistry; developing analytical methods for genomics and proteomics, expanding the functional repertoire of natural macromolecular assemblies, remodelling enzymes and toxins.
近期论文
Snijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA, Hurd PJ & Dickman MJ (2015) Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA. RNA, 21(3), 347-359. View this article in WRRO Qureshi MS, Sheikh QI, Hill R, Brown PE, Dickman MJ, Tzokov SB, Rice DW, Gjerde DT & Hornby DP (2013) Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes.. Anal Biochem, 439(1), 47-49. Xu W, Liu L, Brown NJ, Christian S & Hornby D (2012) Quantum dot-conjugated anti-GRP78 scFv inhibits cancer growth in mice.. Molecules, 17(1), 796-808. Xu W, Liu L & Hornby D (2012) c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.. Molecules, 17(10), 12086-12101. Waghmare SP, Pousinis P, Hornby DP & Dickman MJ (2009) Studying the mechanism of RNA separations using RNA chromatography and its application in the analysis of ribosomal RNA and RNA:RNA interactions.. J Chromatogr A, 1216(9), 1377-1382. Hanna C, Gjerde D, Nguyen L, Dickman M, Brown P & Hornby D (2006) Micro-scale open-tube capillary separations of functional proteins. ANAL BIOCHEM, 350(1), 128-137. Dickman MJ & Hornby DP (2006) Enrichment and analysis of RNA centered on ion pair reverse phase methodology.. RNA, 12(4), 691-696. Dickman MJ, Sedelnikova SE, Rafferty JB & Hornby DP (2004) Rapid analysis of protein-nucleic acid complexes using MALDI TOF mass spectrometry and ion pair reverse phase liquid chromatography.. J Biochem Biophys Methods, 58(1), 39-48. Brown PE, Hornby DP & Dickman MJ (2004) Identification of nuclear protein complexes using open tube capillary chromatography. AIChE Annual Meeting, Conference Proceedings, 1917. Harris VH, Smith CL, Cummins WJ, Hamilton AL, Hornby DP & Williams DM (2003) Recognition of base-pairing by DNA polymerases during nucleotide incorporation: the properties of the mutagenic nucleotide dPTP alphaS.. Org Biomol Chem, 1(12), 2070-2074.