Career History

2013 - present: Lecturer, Dept. of Molecular Biology and Biotechnology, University of Sheffield, UK 2008 - 2012: Senior Research Associate, Centre for Molecular Microbiology and Infection, Imperial College London, UK 2005 - 2008: Research Associate, Centre for Molecular Microbiology and Infection, Imperial College London, UK 2001 - 2005: PhD student, Moyne Institute of Preventive Medicine, Trinity College, University of Dublin, Ireland

S-layer and host interaction of Clostridium difficile: a spore-forming, anaerobic, Gram-positive bacterium which causes severe disease in patients following antibiotic treatment for unrelated infections.

Kirk J & Fagan R (2016) Heat shock increases conjugation efficiency in Clostridium difficile. Anaerobe, 42, 1-5. View this article in WRRO Janganan TK, Mullin N, Tzokov SB, Stringer S, Fagan RP, Hobbs JK, Moir A & Bullough PA (2016) Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for C. botulinum Group I strains. Food Microbiology, 59, 205-212. View this article in WRRO Kirk JA, Banerji O & Fagan RP (2016) Characteristics of the Clostridium difficile cell envelope and its importance in therapeutics.. Microb Biotechnol. View this article in WRRO Buckley AM, Jukes C, Candlish D, Irvine JJ, Spencer J, Fagan RP, Roe AJ, Christie JM, Fairweather NF & Douce GR (2016) Lighting Up Clostridium Difficile: Reporting Gene Expression Using Fluorescent Lov Domains.. Sci Rep, 6, 23463-23463. View this article in WRRO Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF & Fagan RP (2015) High-Throughput Analysis of Gene Essentiality and Sporulation in Clostridium difficile. MBIO, 6(2). View this article in WRRO Willing SE, Candela T, Shaw HA, Seager Z, Mesnage S, Fagan RP & Fairweather NF (2015) Clostridium difficile surface proteins are anchored to the cell wall using CWB2 motifs that recognise the anionic polymer PSII. Molecular Microbiology, 96(3), 596-608. View this article in WRRO Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP, Barquist L, Martin MJ, Goulding D, Duncan SH, Flint HJ, Dougan G, Choudhary JS & Lawley TD (2014) Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism. BMC Genomics, 15, 160-160. View this article in WRRO Fagan RP & Fairweather NF (2014) Biogenesis and functions of bacterial S-layers.. Nature Reviews Microbiology, 12, 211-222. View this article in WRRO Deakin LJ, Clare S, Fagan RP, Dawson LF, Pickard DJ, West MR, Wren BW, Fairweather NF, Dougan G & Lawley TD (2012) The Clostridium difficile spo0A gene is a persistence and transmission factor.. Infect Immun, 80(8), 2704-2711. View this article in WRRO Mahon V, Fagan RP & Smith SG (2012) Snap denaturation reveals dimerization by AraC-like protein Rns.. Biochimie, 94(9), 2058-2061. View this article in WRRO