2013-present: Lecturer in Biological Mass Spectrometry, University of Sheffield 2011-2013: Senior Staff Scientist, Wellcome Trust Sanger Institute 2005-2011: Research Associate/Staff Scientist, Wellcome Trust Sanger Institute 2001-2005: PhD, Division of Neuroscience, University of Edinburgh 2000-2001: Research Assistant, Centre for Liver Disease, Mater Misericordiae University Hospital, Dublin. 1996-2000: BSc, Department of Biochemistry, University College Dublin

Cell Signalling & Proteome Dynamics We are interested in how proteins are regulated by post-translational modifications and how this process affects cell signalling pathways. Protein phosphorylation, ubiquitination and palmitoylation regulate overlapping and distinct aspects of protein function, but the interplay of these modifications is not well understood.

We exploit biochemical and quantitative mass spectrometry-based approaches to understand how proteins are dynamically regulated by protein synthesis and degradation and an array of post-translational modifications.

Brochet, M., Collins, M. O., Smith, T. K., Thompson, E., Sebastian, S., Volkmann, K., Billker, O. (2014). Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites. PLoS Biology, 12(3), e1001806. Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., Sklar, P. (2014). A polygenic burden of rare disruptive mutations in schizophrenia. Nature, 506(7487), 185-190.