Luca Dell’Amico was born in Carrara, Italy, Tuscany. In 2010, he completed his M.Sc. in Medicinal Chemistry at the Parma University under the supervision of Prof. Giovanni Casiraghi, working on the development of novel eco-friendly vinylogous methods. In the same year he started his PhD in “Stereoselective Synthesis of Biologically Active Compounds” under the supervision of Prof. Franca Zanardi. In 2013, he spent a ten-months research period at the Center for Catalysis of Århus Univesity, Denmark, where he was introduced to the field of organocatalysis by Prof. Karl Anker Jørgensen. Luca completed his PhD with highest honours and the Doctor Europaeus mention at the Parma University in 2014. Shortly after, he moved to the ICIQ, Tarragona, Catalunya, joining the group of Prof. Paolo Melchiorre as a Marie-Curie cofund fellow. During this time he worked on the development of novel stereoselective light-driven processes. In the end of 2016, he started his independent career at the Padova University as an assistant professor (tenure track). Since 2022 is associate Professor in Organic Chemistry at the same institution. In 2022, he was awarded an ERC starting grant to investigate new mechanistic pathways in organophotoredox catalysis. His research spans from the design and study of novel organophotoredox catalysts to the investigation of stereoselective photochemical processes. Luca is an active member of the LGBTQ+ community, and since 2024 he is the official representative for the Department of Chemical Sciences in the STEM Equal Opportunities Commission of the University of Padova. Selected awards and distinctions 2024 Representative for the Department of Chemical Sciences in the Equal Opportunities Commission of the University of Padova. 2023 National scientific habilitation to full professorship 2023 Chem. Commun. themed collection: 2023 Pioneering Investigators 2022 ERC-Starting Grant 2021 (European Research Cuncil) 2021 Junior Scientist Program (JSP) Fellowship (Swiss Chemical Society, Bürgenstock) 2020 YourJOC Talents collection of EurJOC 2020 Thieme Chemistry Journals Award 2019 Giacomo Ciamician Medal – From the Italian Chemical Society 2018 Secretary of the European Winter School in Physical Organic Chemistry 2018 Chemical Communication Emerging investigator Issue 2014 Marie-Curie cofund Fellowship – At ICIQ, Tarragona, Spain

Asymmetric Organocatalysis Small chiral organic molecules can be used to catalyse innovative synthetic transformations. We can use covalent or H-bonding enantioselective catalysis to access new chiral bioactive ingredients Mechanistic Investigations We use various spectroscopic and analytical techniques to elucidate the intimate nature of diverse polar and radical processes Photocatalysis Photocatalysis allows unique reactivity pathways, often unaccesible under polar chemistry. We use light to develop unprecedented reactivity and new molecular scaffolds

Ricardo I. Rodríguez, Vasco Corti, Lorenzo Rizzo, Stefano Visentini, Marco Bortolus, Agnese Amati, Mirco Natali, Giorgio Pelosi, Paolo Costa, and Luca Dell’Amico * Nature Catal. 2024, DOI: 10.1038/s41929-024-01206-4. Photocatalytic a-Difluoroalkoxyketones Synthesis via Radical Intermolecular Alkoxylation of Difluoroenol Silyl Ethers Julien Paut, Simone Baldon, Elsa Anselmi, Luca Dell’Amico,* Guillaume Dagousset,* and Emmanuel Magnier* Invited contribution to the issue Fluorine Chemistry: An Outlook to the Future – Adv. Synth. Catal. 2024, 366, 3500 – 3504. DOI: 10.1002/adsc.202400510. Functionalization of Sulfones, Sulfonamides and Sulfoximines José J. Garrido-González, Katy Medrano-Uribe, Cristian Rosso, Jorge Humbrías-Martín, and Luca Dell’Amico * Invited perspective article – Chem. Eur. J. 2024, 30, e202401307. Electrochemical Asymmetric Radical Functionalization of Aldehydes Enabled by a Redox Shuttle Daniele Mazzarella,* Chun Qi, Michael Vanzella, Andrea Sartorel, Giorgio Pelosi, and Luca Dell’Amico * Angew. Chem. Int. Ed., 2024. DOI: 10.1002/anie.202401361. The impact of UV-light on synthetic photochemistry and photocatalysis Giulio Goti, Kavyasree Manal, Jayaraman Sivaguru,* and Luca Dell’Amico * Nat. Chem., 2024. DOI: s41557-024-01472-67333. Light-Driven Synthesis and Functionalization of Bicycloalkanes, Cubanes and Related Bioisosteres Sara Cuadros, Julien Paut, Elsa Anselmi, Guillaume Dagousset, Emmanuel Magnier, and Luca Dell’Amico * Angew. Chem. Int. Ed., 2024, e202317333. DOI: 10.1002/anie.202317333. Photocatalytic (3+2) Dipolar Cycloadditions of Aziridines Driven by Visible-Light Daniele Mazzarella, Tommaso Bortolato, Giorgio Pelosi and Luca Dell’Amico* Chem. Sci. 2023, DOI: 10.1039/D3SC05997A. A General Organophotoredox Strategy to Difluoroalkyl Bicycloalkane (CF2-BCA) Hybrid Bioisosteres Sara Cuadros, Giulio Goti, Giorgia Barison, Alfredo Raulli, Tommaso Bortolato, Giorgio Pelosi, Paolo Costa and Luca Dell’Amico* Angew. Chem. Int. Ed. 2023, DOI: 10.1002/ange.20230358 5. Self-assembly of benzophenone-diphenylalanine conjugate into a nanostructured photocatalyst Simone Adorinni, Giulio Goti, Lorenzo Rizzo, Federica Grassi, Slavko Kralj, Fatima Matroodi, Mirco Natali, Rita De Zorzi, Silvia Marchesan,* and Luca Dell’Amico* Invited contribution to the Chem. Commun. themed collection: 2023 Pioneering Investigators – Chem. Commun. 2023, DOI: 10.1039/D3CC01673K. Building C–C bridges with oxalic acid as a traceless keystone Daniele Mazzarella, and Luca Dell’Amico* Invited preview article – Chem 2023, 4, 766–768. DOI: 10.1016/j.chempr.2023.03.024. A Proton-Coupled Electron Transfer Strategy to the Redox-Neutral Photocatalytic CO2 Fixation Pietro Franceschi, Elena Rossin, Giulio Goti, Angelo Scopano, Alberto Vega-Peñaloza, Mirco Natali, Deepak Singh, Andrea Sartorel,* and Luca Dell’Amico* J. Org. Chem. 2023, DOI: 10.1021/acs.joc.2c02952. Mechanisms and Synthetic Strategies in Visible-Light-Driven [2+2]-Heterocycloadditions Pietro Franceschi, Sara Cuadros, Giulio Goti, and Luca Dell’Amico* Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202217210 The Rational Design of Reducing Organophotoredox Catalysts Unlocks Proton-Coupled Electron-Transfer and Atom Transfer Radical Polymerization Mechanisms Tommaso Bortolato, Gianluca Simionato, Marie Vayer, Cristian Rosso, Lorenzo Paoloni, Edmondo M. Benetti, Andrea Sartorel, David Lebœuf,* and Luca Dell’Amico* J. Am. Chem. Soc. 2023, DOI:10.1021/jacs.2c11364 Unveiling the impact of the light source and steric factors on [2 + 2] heterocycloaddition reactions Javier Mateos, Francesco Rigodanza, Paolo Costa, Mirco Natali, Alberto Vega-Peñaloza, Elisa Fresch, Elisabetta Collini, Marcella Bonchio, Andrea Sartorel, and Luca Dell’Amico* Nat. Synth. 2022. DOI: 10.1038/s44160-022-00191-5. Giving ketones the green light Giulio Goti, and Luca Dell’Amico* News & Views invited article – Nat. Synth. 2022, 1, 101–102. DOI: 10.1038/s44160-022-00026-3 The Photochemical Activity of a Halogen-Bonded Complex Enables the Microfluidic Light-Driven Alkylation of Phenols Sara Cuadros, Cristian Rosso, Giorgia Barison, Paolo Costa, Marcella Bonchio, Maurizio Prato, Giacomo Filippini,* and Luca Dell’Amico* Org. Lett. 2022, 24, 2961–2966. DOI: 10.1021/acs.orglett.2c00604 – Open access as author choice. Unveiling the Synthetic Potential of Substituted Phenols as Fully Recyclable Organophotoredox Catalysts for the Iodosulfonylation of Olefins Cristian Rosso, Sara Cuadros, Giorgia Barison, Paolo Costa, Marcella Bonchio, Maurizio Prato, Luca Dell’Amico,* Giacomo Filippini* ACS Catal. 2022, 12, 4290−4295. DOI: 10.1021/acscatal.2c00565 – Open access as author choice. Properties and Synthetic Performances of Phenylamino Cyanoarenes under One-Photon Excitation Manifolds Tommaso Bortolato, Mateusz Dyguda, Alberto Vega-Penaloza,* and Luca Dell’Amico* Synthesis 2022, DOI: 10.1055/a-1776-0929. Invited contribution to the Bürgenstock Conference 2021 issue of Synthesis. The Advent and Development of Organophotoredox Catalysis Tommaso Bortolato, Sara Cuadros, Gianluca Simionato, and Luca Dell’Amico* Chem. Commun. 2022, 58, 1263–1283. DOI: 10.1039/D1CC05850A Radical α-Trifluoromethoxylation of Ketones under Batch and Flow Conditions by Means of Organic Photoredox Catalysis Thibaut Duhail, Tommaso Bortolato, Javier Mateos, Elsa Anselmi, Benson Jelier, Antonio Togni, Emmanuel Magnier,* Guillaume Dagousset,* and Luca Dell’Amico* Org. Lett. 2021, 23, 7088–7093. DOI: 10.1021/acs.orglett.1c02494 – Open access as author choice